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    Psme3 proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) [ Mus musculus (house mouse) ]

    Gene ID: 19192, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Psme3provided by MGI
    Official Full Name
    proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)provided by MGI
    Primary source
    MGI:MGI:1096366
    See related
    Ensembl:ENSMUSG00000078652 AllianceGenome:MGI:1096366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ki; pa28g; REGgamma; PA28gamma
    Summary
    Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; endopeptidase activator activity; and p53 binding activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway; regulation of G1/S transition of mitotic cell cycle; and regulation of proteolysis. Predicted to be located in cytosol. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in genitourinary system and ventricular layer. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 81.8), liver E14 (RPKM 74.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psme3 in Genome Data Viewer
    Location:
    11 D; 11 64.67 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101206090..101214363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101316213..101323537)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytochrome C oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1, autophagy related Neighboring gene STARR-positive B cell enhancer ABC_E2370 Neighboring gene STARR-positive B cell enhancer ABC_E7066 Neighboring gene amine oxidase copper containing 2 Neighboring gene amine oxidase, copper containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immune defects in 28-kDa proteasome activator gamma-deficient mice. Barton LF, et al. J Immunol, 2004 Mar 15. PMID 15004203
    2. The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Dong S, et al. Cell Metab, 2013 Sep 3. PMID 24011073, Free PMC Article
    3. Growth retardation in mice lacking the proteasome activator PA28gamma. Murata S, et al. J Biol Chem, 1999 Dec 31. PMID 10608895
    4. Loss of PA28γ exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice. Chen Q, et al. J Bone Miner Res, 2024 Apr 19. PMID 38477820
    5. MicroRNA‑195‑5p inhibitor prevents the development of osteoarthritis by targeting REGγ. Shu Y, et al. Mol Med Rep, 2019 Jun. PMID 30942447, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. REGgamma Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
      Title: REGγ Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
    2. Loss of PA28gamma exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice.
      Title: Loss of PA28γ exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice.
    3. Aging-associated REGgamma proteasome decline predisposes to tauopathy.
      Title: Aging-associated REGγ proteasome decline predisposes to tauopathy.
    4. 11S Proteasome Activator REGgamma Promotes Aortic Dissection by Inhibiting RBM3 (RNA Binding Motif Protein 3) Pathway.
      Title: 11S Proteasome Activator REGγ Promotes Aortic Dissection by Inhibiting RBM3 (RNA Binding Motif Protein 3) Pathway.
    5. Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis.
      Title: Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis.
    6. REGgamma controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells.
      Title: REGγ controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells.
    7. REGgamma regulates hair cycle by activating Lgr5 positive hair follicle stem cells.
      Title: REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells.
    8. The proteasome activator REGgamma counteracts immunoproteasome expression and autoimmunity.
      Title: The proteasome activator REGγ counteracts immunoproteasome expression and autoimmunity.
    9. The results of the present study also indicated that all of the effects of the miR1955p inhibitor on ATDC5 cells were reversed by REGgamma silencing. The results also revealed that a miR1955p inhibitor inhibited the LPS induced repression of the Wnt/betacatenin signaling pathway and activation of nuclear factor (NF)kappaB signaling pathway in ATDC5 cells.
      Title: MicroRNA‑195‑5p inhibitor prevents the development of osteoarthritis by targeting REGγ.
    10. REGgamma regulates NFkappaB activity by specifically degrading IkBepsilon to regulate inflammation in testicular Leydig cells.
      Title: Proteasome activator REGγ promotes inflammation in Leydig cells via IkBε signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MDM2/MDM4 family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables endopeptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome activator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome activator complex subunit 3
    Names
    11S regulator complex subunit gamma
    REG-gamma
    activator of multicatalytic protease subunit 3
    ki nuclear autoantigen
    proteaseome (prosome, macropain) 28 subunit, 3
    proteasome activator 28 subunit gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011192.4 → NP_035322.1  proteasome activator complex subunit 3

      See identical proteins and their annotated locations for NP_035322.1

      Status: VALIDATED

      Source sequence(s)
      AK140597, AW490477, BF456075, BY324327
      Consensus CDS
      CCDS25463.1
      UniProtKB/Swiss-Prot
      P61290
      UniProtKB/TrEMBL
      Q4FK54
      Related
      ENSMUSP00000019470.8, ENSMUST00000019470.14
      Conserved Domains (2) summary
      pfam02251
      Location:9 → 69
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:109 → 251
      PA28_beta; Proteasome activator pa28 beta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101206090..101214363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156432.1 → XP_036012325.1  proteasome activator complex subunit 3 isoform X3

      Conserved Domains (2) summary
      pfam02251
      Location:9 → 46
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:74 → 216
      PA28_beta; Proteasome activator pa28 beta subunit

    2. XM_030245676.1 → XP_030101536.1  proteasome activator complex subunit 3 isoform X1

      Conserved Domains (2) summary
      pfam02251
      Location:25 → 80
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:119 → 263
      PA28_beta; Proteasome activator pa28 beta subunit

    3. XM_036156431.1 → XP_036012324.1  proteasome activator complex subunit 3 isoform X2

      Conserved Domains (2) summary
      pfam02251
      Location:25 → 67
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:85 → 227
      PA28_beta; Proteasome activator pa28 beta subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61290.1 GenPept UniProtKB/Swiss-Prot:P61290

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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