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    Prep prolyl endopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 19072, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prepprovided by MGI
    Official Full Name
    prolyl endopeptidaseprovided by MGI
    Primary source
    MGI:MGI:1270863
    See related
    Ensembl:ENSMUSG00000019849 AllianceGenome:MGI:1270863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PE; PEP; Pop; D10Wsu136e
    Summary
    Predicted to enable oligopeptidase activity and peptide binding activity. Predicted to be involved in protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including cranial ganglion; genitourinary system; heart ventricle; thymus primordium; and vibrissa. Orthologous to human PREP (prolyl endopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 28.1), placenta adult (RPKM 26.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prep in Genome Data Viewer
    Location:
    10 B2; 10 23.27 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (44943312..45038847)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (45067216..45162751)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40639 Neighboring gene STARR-positive B cell enhancer ABC_E5136 Neighboring gene STARR-seq mESC enhancer starr_26566 Neighboring gene RIKEN cDNA 2310075K07 gene Neighboring gene STARR-seq mESC enhancer starr_26567 Neighboring gene STARR-seq mESC enhancer starr_26571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:44823099-44823208 Neighboring gene STARR-seq mESC enhancer starr_26573 Neighboring gene STARR-seq mESC enhancer starr_26574 Neighboring gene VISTA enhancer mm87 Neighboring gene STARR-seq mESC enhancer starr_26575 Neighboring gene predicted gene, 26016 Neighboring gene predicted gene 15934 Neighboring gene popeye domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression and localization of prolyl oligopeptidase in mouse testis and its possible involvement in sperm motility. Kimura A, et al. Zoolog Sci, 2002 Jan. PMID 12025410
    2. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Kim JD, et al. Proc Natl Acad Sci U S A, 2014 Aug 12. PMID 25071172, Free PMC Article
    3. A long non-coding RNA transcribed from conserved non-coding sequences contributes to the mouse prolyl oligopeptidase gene activation. Matsubara S, et al. J Biochem, 2014 Apr. PMID 24369296
    4. Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity. Di Daniel E, et al. Mol Cell Neurosci, 2009 Jul. PMID 19332125
    5. Prolyl Endopeptidase (PREP) is Associated With Male Reproductive Functions and Gamete Physiology in Mice. Dotolo R, et al. J Cell Physiol, 2016 Mar. PMID 26332268

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A.
      Title: Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A.
    2. POP regulates progesterone secretion by stimulating the expression of CYP11A, 3beta-HSD, and StAR in luteal cells. ERK signaling and downstream SF1 expression contribute to this process.
      Title: Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells.
    3. Results strongly suggest that there is a pivotal role for Prolyl endopeptidase (PREP) in vesicle exocytosis, as well as in the physiology of mouse seminal vesicles.
      Title: Study on PREP localization in mouse seminal vesicles and its possible involvement during regulated exocytosis.
    4. Prolyl oligopeptidase expression and role in the placental spongiotrophoblast differentiation.
      Title: A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase.
    5. PREP regulates the function of dopamine transporter, possibly by controlling the phosphorylation and transport of dopamine transporter into the striatum or synaptic membrane.
      Title: Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse.
    6. Taken together, these data suggest that PREP can enhance alpha-synuclein toxicity in vivo.
      Title: Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo.
    7. involved in trophoblast stem cell differentiation in placenta
      Title: Mouse prolyl oligopeptidase plays a role in trophoblast stem cell differentiation into trophoblast giant cell and spongiotrophoblast.
    8. These findings might be explained as possible alteration in brain plasticity caused by PREP deficiency, which in turn affect behaviour and brain development
      Title: Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume.
    9. Lung ischemia-reperfusion injury causes a dysregulation of circulating Ang 2 levels and plasma PREP activity, although no direct link between both phenomena could be shown.
      Title: Dysregulation of the renin-angiotensin system during lung ischemia-reperfusion injury.
    10. TLR4 activation releases prolyl endopeptidase containing exosomes from airway epithelial cells.
      Title: Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oligopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl endopeptidase
    Names
    post-proline cleaving enzyme
    prolyl oligopeptidase
    NP_035286.1
    XP_011241444.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011156.3 → NP_035286.1  prolyl endopeptidase

      See identical proteins and their annotated locations for NP_035286.1

      Status: VALIDATED

      Source sequence(s)
      AC153535, AK076257, AK163774, BP759584
      Consensus CDS
      CCDS23826.1
      UniProtKB/Swiss-Prot
      Q80YS1, Q9QUR6
      UniProtKB/TrEMBL
      Q3TCS0, Q543B9
      Related
      ENSMUSP00000097444.3, ENSMUST00000099858.4
      Conserved Domains (2) summary
      COG1505
      Location:26 → 704
      PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
      pfam00326
      Location:482 → 707
      Peptidase_S9; Prolyl oligopeptidase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      44943312..45038847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243142.3 → XP_011241444.1  prolyl endopeptidase isoform X1

      Conserved Domains (1) summary
      COG1505
      Location:9 → 477
      PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUR6.1 GenPept UniProtKB/Swiss-Prot:Q9QUR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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