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    Ovol1 ovo like zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 18426, updated on 28-Oct-2024

    Summary

    Official Symbol
    Ovol1provided by MGI
    Official Full Name
    ovo like zinc finger 1provided by MGI
    Primary source
    MGI:MGI:1330290
    See related
    Ensembl:ENSMUSG00000024922 AllianceGenome:MGI:1330290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ovo1; movo1
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; negative regulation of transcription by RNA polymerase II; and regulation of meiotic cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human OVOL1 (ovo like transcriptional repressor 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in duodenum adult (RPKM 17.2), small intestine adult (RPKM 13.4) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Ovol1 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5599165..5610603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5549137..5560575, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8730 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5491370-5491523 Neighboring gene cofilin 1, non-muscle Neighboring gene sorting nexin 32 Neighboring gene STARR-positive B cell enhancer ABC_E1208 Neighboring gene NSE3 homolog, SMC5-SMC6 complex component like Neighboring gene predicted gene, 31166 Neighboring gene adaptor-related protein complex 5, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_45393 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5601776-5601959 Neighboring gene ribonuclease H2, subunit C Neighboring gene STARR-positive B cell enhancer ABC_E11011 Neighboring gene K(lysine) acetyltransferase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in epidermal cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within epidermis development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within germline cell cycle switching, mitotic to meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of keratinocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of meiotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of keratinocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of meiotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of stem cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of stem cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative transcription factor Ovo-like 1
    Names
    OVO homolog-like 1
    mOvo1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019935.3NP_064319.1  putative transcription factor Ovo-like 1

      See identical proteins and their annotated locations for NP_064319.1

      Status: VALIDATED

      Source sequence(s)
      AK028577
      Consensus CDS
      CCDS29469.1
      UniProtKB/Swiss-Prot
      Q545S2, Q9WTJ2
      UniProtKB/TrEMBL
      Q3UME7
      Related
      ENSMUSP00000025861.2, ENSMUST00000025861.3
      Conserved Domains (3) summary
      sd00017
      Location:120140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:118138
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:160185
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5599165..5610603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531676.5XP_006531739.1  putative transcription factor Ovo-like 1 isoform X2

      See identical proteins and their annotated locations for XP_006531739.1

      Conserved Domains (2) summary
      sd00017
      Location:5878
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:98123
      zf-H2C2_2; Zinc-finger double domain
    2. XM_011248605.4XP_011246907.1  putative transcription factor Ovo-like 1 isoform X1

      UniProtKB/TrEMBL
      Q3UME7
      Conserved Domains (3) summary
      sd00017
      Location:89109
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:87107
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:129154
      zf-H2C2_2; Zinc-finger double domain
    3. XM_006531675.5XP_006531738.1  putative transcription factor Ovo-like 1 isoform X2

      See identical proteins and their annotated locations for XP_006531738.1

      Conserved Domains (2) summary
      sd00017
      Location:5878
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:98123
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011248606.4XP_011246908.1  putative transcription factor Ovo-like 1 isoform X2

      See identical proteins and their annotated locations for XP_011246908.1

      Conserved Domains (2) summary
      sd00017
      Location:5878
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:98123
      zf-H2C2_2; Zinc-finger double domain