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    Meox1 mesenchyme homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 17285, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Meox1provided by MGI
    Official Full Name
    mesenchyme homeobox 1provided by MGI
    Primary source
    MGI:MGI:103220
    See related
    Ensembl:ENSMUSG00000001493 AllianceGenome:MGI:103220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mox1; Mox-1; squig; D330041M02Rik
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and sclerotome development. Acts upstream of or within somite specification. Located in cytoplasm and nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; limb; and musculoskeletal system. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Orthologous to human MEOX1 (mesenchyme homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 6.9), heart adult (RPKM 3.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Meox1 in Genome Data Viewer
    Location:
    11 D; 11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101768336..101785309, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101877510..101894354, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3025 Neighboring gene DEAH-box helicase 8 Neighboring gene STARR-seq mESC enhancer starr_30780 Neighboring gene STARR-positive B cell enhancer ABC_E2371 Neighboring gene STARR-seq mESC enhancer starr_30781 Neighboring gene ets variant 4 Neighboring gene predicted gene, 39392 Neighboring gene STARR-positive B cell enhancer mm9_chr11:101674595-101674896 Neighboring gene STARR-seq mESC enhancer starr_30783 Neighboring gene STARR-seq mESC enhancer starr_30784 Neighboring gene predicted gene, 33662 Neighboring gene ribosomal protein L27, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The squiggle tail (squig) mutation in mice is associated with a deletion in the mesenchyme homeobox 1 (Meox1) gene. Girard JP 2nd, et al. BMC Res Notes, 2022 Sep 23. PMID 36138442, Free PMC Article
    2. Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development. Candia AF, et al. Int J Dev Biol, 1996 Dec. PMID 9032023
    3. A transcriptional switch governs fibroblast activation in heart disease. Alexanian M, et al. Nature, 2021 Jul. PMID 34163071, Free PMC Article
    4. Mesenchyme homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors. Dong K, et al. J Biol Chem, 2018 Jun 1. PMID 29678882, Free PMC Article
    5. Meox1 accelerates myocardial hypertrophic decompensation through Gata4. Lu D, et al. Cardiovasc Res, 2018 Feb 1. PMID 29155983

    See all (204) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The squiggle tail (squig) mutation in mice is associated with a deletion in the mesenchyme homeobox 1 (Meox1) gene.
      Title: The squiggle tail (squig) mutation in mice is associated with a deletion in the mesenchyme homeobox 1 (Meox1) gene.
    2. A transcriptional switch governs fibroblast activation in heart disease.
      Title: A transcriptional switch governs fibroblast activation in heart disease.
    3. Meox1 accelerated myocardial hypertrophic decompensation via the downstream target Gata4, at least in part directly.
      Title: Meox1 accelerates myocardial hypertrophic decompensation through Gata4.
    4. transcriptional regulator Meox1 controls TGF-beta-induced SMC differentiation from mesenchymal progenitor cells by preventing PPM1A-mediated Smad3 dephosphorylation
      Title: Mesenchyme homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors.
    5. MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner.
      Title: Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.
    6. Meox1 expression is downregulated in the second arch of Hoxa2 mouse mutant embryos.
      Title: Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.
    7. Data sugges that Meox1 is part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal sclerotome polarity and axial skeleton formation.
      Title: Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.
    8. Meox and Gli have roles in skeletal myogenesis
      Title: Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells.
    9. Data show that Meox1 activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 and/or Pax9.
      Title: Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter.
    10. Results demonstrate that Meox1 and Meox2 genes function together and upstream of several genetic hierarchies that are required for the development of somites.
      Title: The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables HMG box domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in hematopoietic stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sclerotome development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in somite development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in somite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somite specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein MOX-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010791.3 → NP_034921.1  homeobox protein MOX-1

      See identical proteins and their annotated locations for NP_034921.1

      Status: VALIDATED

      Source sequence(s)
      BC011082
      Consensus CDS
      CCDS25480.1
      UniProtKB/Swiss-Prot
      P32442, Q543E8
      Related
      ENSMUSP00000051158.8, ENSMUST00000057054.8
      Conserved Domains (2) summary
      COG5576
      Location:139 → 253
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:174 → 227
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101768336..101785309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156374.1 → XP_036012267.1  homeobox protein MOX-1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32442.1 GenPept UniProtKB/Swiss-Prot:P32442

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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