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    Rab3il1 RAB3A interacting protein-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171452, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Rab3il1provided by RGD
    Official Full Name
    RAB3A interacting protein-like 1provided by RGD
    Primary source
    RGD:619764
    See related
    EnsemblRapid:ENSRNOG00000020349 AllianceGenome:RGD:619764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Grab
    Summary
    Enables guanyl-nucleotide exchange factor activity and kinase binding activity. Predicted to be involved in exocytosis. Predicted to be active in Golgi to plasma membrane transport vesicle. Orthologous to human RAB3IL1 (RAB3A interacting protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 335.5), Spleen (RPKM 245.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab3il1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216071043..216107609)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206646168..206682718)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226077182..226084830)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene UPF0462 protein C4orf33 homolog Neighboring gene ferritin heavy chain 1 Neighboring gene bestrophin 1 Neighboring gene fatty acid desaturase 3 Neighboring gene fatty acid desaturase 2 Neighboring gene uncharacterized LOC134483970

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. Luo HR, et al. Neuron, 2001 Aug 16. PMID 11516400
    2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
    3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
    4. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor for Rab-3A
    Names
    RAB3A interacting protein (rabin3)-like 1
    guanine nucleotide exchange factor for Rab3A
    rab-3A-interacting-like protein 1
    rab3A-interacting-like protein 1
    rabin3-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134411.2 → NP_599238.1  guanine nucleotide exchange factor for Rab-3A

      See identical proteins and their annotated locations for NP_599238.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q99NH3
      UniProtKB/TrEMBL
      A6I005, F1LPG6
      Related
      ENSRNOP00000093310.1, ENSRNOT00000096923.2
      Conserved Domains (1) summary
      pfam06428
      Location:92 → 160
      Sec2p; GDP/GTP exchange factor Sec2p

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216071043..216107609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277147.1 → XP_063133217.1  guanine nucleotide exchange factor for Rab-3A isoform X6

      UniProtKB/TrEMBL
      A0A8I6ANE5
      Related
      ENSRNOP00000097403.1, ENSRNOT00000116053.2

    2. XM_039090212.2 → XP_038946140.1  guanine nucleotide exchange factor for Rab-3A isoform X3

      UniProtKB/TrEMBL
      F1LPG6
      Conserved Domains (2) summary
      pfam06428
      Location:98 → 166
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:272 → 428
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    3. XM_063277108.1 → XP_063133178.1  guanine nucleotide exchange factor for Rab-3A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZYP6
      Related
      ENSRNOP00000084085.1, ENSRNOT00000101634.2

    4. XM_039090274.2 → XP_038946202.1  guanine nucleotide exchange factor for Rab-3A isoform X8

      UniProtKB/TrEMBL
      F1LPG6
      Conserved Domains (2) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:197 → 353
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    5. XM_039090314.2 → XP_038946242.1  guanine nucleotide exchange factor for Rab-3A isoform X8

      UniProtKB/TrEMBL
      F1LPG6
      Conserved Domains (2) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:197 → 353
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    6. XM_039090223.2 → XP_038946151.1  guanine nucleotide exchange factor for Rab-3A isoform X4

      UniProtKB/TrEMBL
      F1LPG6
      Conserved Domains (2) summary
      pfam06428
      Location:92 → 160
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:266 → 422
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    7. XM_063277169.1 → XP_063133239.1  guanine nucleotide exchange factor for Rab-3A isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y161
      Related
      ENSRNOP00000077084.1, ENSRNOT00000099098.2

    8. XM_039090207.2 → XP_038946135.1  guanine nucleotide exchange factor for Rab-3A isoform X2

      Conserved Domains (2) summary
      pfam06428
      Location:139 → 207
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:313 → 469
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    9. XM_039090191.2 → XP_038946119.1  guanine nucleotide exchange factor for Rab-3A isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATQ8, F1LPG6
      Related
      ENSRNOP00000097844.2, ENSRNOT00000118090.2
      Conserved Domains (2) summary
      pfam06428
      Location:92 → 160
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:266 → 422
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NH3.1 GenPept UniProtKB/Swiss-Prot:Q99NH3

    Gene LinkOut

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