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    Acsbg1 acyl-CoA synthetase bubblegum family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171410, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Acsbg1provided by RGD
    Official Full Name
    acyl-CoA synthetase bubblegum family member 1provided by RGD
    Primary source
    RGD:708557
    See related
    EnsemblRapid:ENSRNOG00000011381 AllianceGenome:RGD:708557
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lpd; Grlacs
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid biosynthetic process and ovarian follicle atresia. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ACSBG1 (acyl-CoA synthetase bubblegum family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 344.0) and Brain (RPKM 175.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acsbg1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (63887433..63943486, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (54991294..55047276, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59184111..59240133, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene SKI8 subunit of superkiller complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DNA methylation analysis in malignant pheochromocytoma and paraganglioma. Oishi T, et al. J Clin Transl Endocrinol, 2017 Mar. PMID 29067245, Free PMC Article
    2. Tissue-cell- and species-specific expression of gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in gonads, adrenal and brain. Identification of novel forms in the brain. Li J, et al. J Steroid Biochem Mol Biol, 2006 Mar. PMID 16469493
    3. Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype. Sheng Y, et al. J Steroid Biochem Mol Biol, 2009 Mar. PMID 19167491
    4. Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination. Song SY, et al. J Neurosci Res, 2007 Dec. PMID 17722065
    5. Cloning and characterization of a hormonally regulated rat long chain acyl-CoA synthetase. Tang PZ, et al. Proc Natl Acad Sci U S A, 2001 Jun 5. PMID 11381125, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ovarian follicle atresia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase ACSBG1
    Names
    gonadotropin-regulated long chain acyl CoA synthetase
    lipidosin
    NP_599216.1
    XP_038936682.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134389.1 → NP_599216.1  long-chain-fatty-acid--CoA ligase ACSBG1

      See identical proteins and their annotated locations for NP_599216.1

      Status: PROVISIONAL

      Source sequence(s)
      AF208125
      UniProtKB/Swiss-Prot
      Q924N5
      UniProtKB/TrEMBL
      A0A8L2Q8K6
      Related
      ENSRNOP00000016104.4, ENSRNOT00000016104.6
      Conserved Domains (1) summary
      cd05933
      Location:122 → 716
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      63887433..63943486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080754.2 → XP_038936682.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUY7, A0A8L2Q8K6
      Related
      ENSRNOP00000082463.1, ENSRNOT00000098670.2
      Conserved Domains (1) summary
      cl17068
      Location:163 → 698
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924N5.1 GenPept UniProtKB/Swiss-Prot:Q924N5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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