Magea4 MAGE family member A4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Magea4provided by MGI
Official Full Name: MAGE family member A4provided by MGI
Primary source: MGI:MGI:1333839
See related: Ensembl:ENSMUSG00000033343 AllianceGenome:MGI:1333839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mage-a4
Summary: Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.2 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (71264599..71266611)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (72221015..72222964)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis
Title: A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489225

Magea4 (e-PCR), detects polymorphism
- UniSTS:256623

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanoma-associated antigen 4

Names: melanoma antigen, family A, 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020280.3 → NP_064676.2 melanoma-associated antigen 4

See identical proteins and their annotated locations for NP_064676.2

Status: VALIDATED

Source sequence(s)

AL671874

Consensus CDS

CCDS30185.1

UniProtKB/TrEMBL

F2Z493, Q3SXV1

Related

ENSMUSP00000046715.2, ENSMUST00000048675.2

Conserved Domains (2) summary

pfam01454
Location:161 → 271

MAGE; MAGE family

pfam12440
Location:16 → 84

MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

71264599..71266611

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247539.2 → XP_011245841.1 melanoma-associated antigen 4 isoform X1

Conserved Domains (2) summary

pfam01454
Location:161 → 271

MAGE; MAGE family

pfam12440
Location:16 → 84

MAGE_N; Melanoma associated antigen family N terminal