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    Trpm8 transient receptor potential cation channel, subfamily M, member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171384, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trpm8provided by RGD
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 8provided by RGD
    Primary source
    RGD:620762
    See related
    EnsemblRapid:ENSRNOG00000019035 AllianceGenome:RGD:620762
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CMR1
    Summary
    Enables identical protein binding activity and monoatomic ion channel activity. Involved in calcium ion transmembrane transport and response to cold. Located in plasma membrane raft. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 20.1), Kidney (RPKM 2.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trpm8 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96315567..96437959)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88897039..88990167)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95393370..95484528)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene peptidylprolyl isomerase D, pseudogene 21 Neighboring gene uncharacterized LOC108351971 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene secreted phosphoprotein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional roles of transient receptor potential melastatin 8 (TRPM8) channels in the cold stress-induced detrusor overactivity pathways in conscious rats. Lei Z, et al. Neurourol Urodyn, 2013 Jun. PMID 23001687
    2. [Role of transient receptor potential melastatin 8 channels in migraine mechanism in rats]. Qin DM, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2015 May. PMID 26014706
    3. Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache. Burgos-Vega CC, et al. Cephalalgia, 2016 Feb. PMID 25944818, Free PMC Article
    4. TRPM8 mechanism of cold allodynia after chronic nerve injury. Xing H, et al. J Neurosci, 2007 Dec 12. PMID 18077679, Free PMC Article
    5. TRPM8 mechanism of autonomic nerve response to cold in respiratory airway. Xing H, et al. Mol Pain, 2008 Jun 5. PMID 18534015, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of temperature homeostasis at water balance changes.
      Title: Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of temperature homeostasis at water balance changes.
    2. Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.
      Title: Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.
    3. Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels regulate microglial activity.
      Title: Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels regulate microglial activity.
    4. Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits.
      Title: Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits.
    5. TRIM4 interacts with TRPM8 and regulates its channel function through K423-mediated ubiquitination.
      Title: TRIM4 interacts with TRPM8 and regulates its channel function through K423-mediated ubiquitination.
    6. Acute stress induces visceral hypersensitivity via glucocorticoid receptor-mediated membrane insertion of TRPM8: Involvement of a non-receptor tyrosine kinase Pyk2.
      Title: Acute stress induces visceral hypersensitivity via glucocorticoid receptor-mediated membrane insertion of TRPM8: Involvement of a non-receptor tyrosine kinase Pyk2.
    7. TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin.
      Title: TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin.
    8. Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity.
      Title: Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity.
    9. The effects of TRPM2, TRPM6, TRPM7 and TRPM8 gene expression in hepatic ischemia reperfusion injury.
      Title: The effects of TRPM2, TRPM6, TRPM7 and TRPM8 gene expression in hepatic ischemia reperfusion injury.
    10. These data demonstrate for the first time, the expression and function of TRPM8 channels in the internal pudendal artery involving, at least in part, endothelium-derived relaxing factors and ROCK inhibition. Overall, this channel could potentially be a new target for the treatment of hypertension associated-ED.
      Title: TRPM8 channel activation triggers relaxation of pudendal artery with increased sensitivity in the hypertensive rats.
    Submit: New GeneRIF Correction See all GeneRIFs (72)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligand-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to cold IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to temperature stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within thermoception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily M member 8
    Names
    cold menthol receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134371.3 → NP_599198.2  transient receptor potential cation channel subfamily M member 8

      See identical proteins and their annotated locations for NP_599198.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q8R455
      UniProtKB/TrEMBL
      A6JQJ1
      Related
      ENSRNOP00000025879.4, ENSRNOT00000025879.6
      Conserved Domains (2) summary
      TIGR00870
      Location:657 → 1005
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:116 → 359
      LSDAT_euk; SLOG in TRPM

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      96315567..96437959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082997.2 → XP_038938925.1  transient receptor potential cation channel subfamily M member 8 isoform X1

      UniProtKB/Swiss-Prot
      Q8R455
      UniProtKB/TrEMBL
      A6JQJ1
      Conserved Domains (2) summary
      TIGR00870
      Location:657 → 1005
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:116 → 359
      LSDAT_euk; SLOG in TRPM
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R455.4 GenPept UniProtKB/Swiss-Prot:Q8R455

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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