Rap1b RAP1B, member of RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rap1bprovided by RGD
Official Full Name: RAP1B, member of RAS oncogene familyprovided by RGD
Primary source: RGD:620577
See related: EnsemblRapid:ENSRNOG00000007048 AllianceGenome:RGD:620577
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein activity; GDP binding activity; and GTP binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to xenobiotic stimulus; and response to carbohydrate. Predicted to be located in cell-cell junction; cytosol; and lipid droplet. Predicted to be active in glutamatergic synapse and plasma membrane. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including RAP1B (RAP1B, member of RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 789.4), Lung (RPKM 486.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (55308922..55342217, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (53423039..53456349, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (60850406..60878226, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that mutations at different sites affect the ability of rap GTP-Binding Protein Rap1 to activate appropriately.
Title: The structure and conformational switching of Rap1B.
specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI3-kinase.
Title: Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.
These data establish rap1b as a novel gene rapidly induced by GnRH and a candidate to modulate gonadotropin secretion in rat gonadotropes.
Title: Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes.
Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation.
Title: Rheb and mTOR regulate neuronal polarity through Rap1B.
analysis of a cAMP-Epac/PKA-Rap1b-PP2A signaling module involved in Akt regulation that may represent a physiological event in the process of cAMP stimulation of thyroid mitogenesis
Title: A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation.
cAMP inhibits Akt via Rap1b
Title: cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.
On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b.
Title: On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_2660-2661:991933047:1 (e-PCR)
- UniSTS:230931

BF401892 (e-PCR)
- UniSTS:245544

BF386582 (e-PCR)
- UniSTS:243777

GDB:384854 (e-PCR)
- UniSTS:157109

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rap protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rap protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rap protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to gonadotropin-releasing hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
NOT involved_in microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic structure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
NOT located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rap-1b

Names: GTP-binding protein smg p21B; RAS related protein 1b

NP_001399529.1

EC 3.6.5.2

NP_599173.2

EC 3.6.5.2

XP_038934285.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412600.1 → NP_001399529.1 ras-related protein Rap-1b precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q62636, Q6J167

UniProtKB/TrEMBL

A6IGU3

Related

ENSRNOP00000078778.1, ENSRNOT00000113270.2
NM_134346.4 → NP_599173.2 ras-related protein Rap-1b precursor

See identical proteins and their annotated locations for NP_599173.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q62636, Q6J167

UniProtKB/TrEMBL

A0A8L2UI57, A6IGU3

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

55308922..55342217 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078357.2 → XP_038934285.1 ras-related protein Rap-1b isoform X1

UniProtKB/Swiss-Prot

Q62636, Q6J167

UniProtKB/TrEMBL

A0A8L2UI57, A6IGU3

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms