Abcc4 ATP binding cassette subfamily C member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcc4provided by RGD
Official Full Name: ATP binding cassette subfamily C member 4provided by RGD
Primary source: RGD:620266
See related: EnsemblRapid:ENSRNOG00000010064 AllianceGenome:RGD:620266
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrp4; RGD1565953
Summary: Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Involved in several processes, including bile acid signaling pathway; positive regulation of smooth muscle cell proliferation; and response to xenobiotic stimulus. Located in basolateral plasma membrane and external side of apical plasma membrane. Biomarker of cholestasis and extrahepatic cholestasis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 176.4), Adrenal (RPKM 106.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q24

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (101948387..102182912, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (95541186..95774898, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (103695415..103927980, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate.
Title: The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate.
Inflammation-Induced Attenuation of Prostaglandin D2 Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.
Title: Inflammation-Induced Attenuation of Prostaglandin D(2) Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.
These data suggest that inhibition of MRP4 significantly alleviates sepsis-induced acute lung injury in rats.
Title: Inhibition of MRP4 alleviates sepsis-induced acute lung injury in rats.
Data suggest that MRP4 plays role in pharmacokinetics and pharmacodynamic actions of anti-bacterial ciprofloxacin. In these studies, co-administration of dipyridamole, an inhibitor of MRP4, enhanced AUC/MIC values of ciprofloxacin in both normal and inflamed rats; here, inflammation with E. coli O55-B5 LPS was used as model of inflammation in E. coli infection.
Title: Effect of Multi Drug Resistance Protein 4 (MRP4) Inhibition on the Pharmacokinetics and Pharmacodynamics of Ciprofloxacin in Normal and Rats with LPS-Induced Inflammation.
The data of this study show increased Abcc1, Abcc2, and Abcc4 mRNA expression at the BBB in response to H/R stress and that Abcc gene expression is regulated by Nrf2 signaling.
Title: Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress.
Multidrug resistance-associated proteins 1, 4, 5, and Oatp1a4 were present at the transcript level, but only Mrp1, 4, and 5 were detected at the protein level.
Title: Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens.
Breast cancer resistance protein, the multidrug resistance protein 4 and P-glycoprotein are not involved in the active secretion of PhIP in the rat distal colon.
Title: The colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is actively secreted in the distal colon of the rat: an integrated view on the role of PhIP transport and metabolism in PhIP-induced colon carcinogenesis.
sustained repression and translocation of Ntcp and the expression of Mrp4 at the basolateral membrane seem to be responsible for the high blood bile acids levels after massive hepatectomy
Title: Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy.
ANF signals via natriuretic peptide receptor-C coupled to the phospholipase C-protein kinase C pathway to increase secretin-induced efflux of cAMP, probably through MPR-4 in pancreas
Title: Atrial natriuretic factor stimulates efflux of cAMP in rat exocrine pancreas via multidrug resistance-associated proteins.
MRP4 is the dominant cAMP transporter in preglomerular vascular smooth muscle cells.
Title: Multidrug resistance protein 4 mediates cAMP efflux from rat preglomerular vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

AU047861 (e-PCR)
- UniSTS:110103

BI286235 (e-PCR)
- UniSTS:245281

RH141533 (e-PCR)
- UniSTS:223527

RH143776 (e-PCR)
- UniSTS:233022

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type bile acid transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type bile acid transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type bile acid transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type glutathione S-conjugate transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type glutathione S-conjugate transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutathione transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glutathione transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutathione transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanine nucleotide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables guanine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables guanine nucleotide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables purine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IEA Inferred from Electronic Annotation more info
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in bile acid and bile salt transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cAMP transport	IEA Inferred from Electronic Annotation more info
involved_in cAMP transport	ISO Inferred from Sequence Orthology more info
involved_in cAMP transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glutathione transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in guanine nucleotide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in leukotriene transport	IEA Inferred from Electronic Annotation more info
involved_in leukotriene transport	ISO Inferred from Sequence Orthology more info
involved_in leukotriene transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tetrachloromethane	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urate transport	IEA Inferred from Electronic Annotation more info
involved_in urate transport	ISO Inferred from Sequence Orthology more info
involved_in urate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
NOT located_in cilium	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in external side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in platelet dense granule membrane	IEA Inferred from Electronic Annotation more info
located_in platelet dense granule membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-binding cassette subfamily C member 4

Names: ABC-tranporter; ATP-binding cassette protein C4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4; multidrug resistance-associated protein 4

NP_596902.1

EC 7.6.2.2

EC 7.6.2.3

XP_038948894.1

EC 7.6.2.2

EC 7.6.2.3

XP_038948895.1

EC 7.6.2.2

EC 7.6.2.3

XP_063129992.1

EC 7.6.2.2

EC 7.6.2.3

XP_063129993.1

EC 7.6.2.2

EC 7.6.2.3

XP_063129994.1

EC 7.6.2.2

EC 7.6.2.3

XP_063129995.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133411.1 → NP_596902.1 ATP-binding cassette subfamily C member 4

See identical proteins and their annotated locations for NP_596902.1

Status: PROVISIONAL

Source sequence(s)

AY533524

UniProtKB/Swiss-Prot

F1M3J4, Q6QMG6

UniProtKB/TrEMBL

Q59DL1

Related

ENSRNOP00000033826.7, ENSRNOT00000031036.8

Conserved Domains (5) summary

cd03244
Location:1039 → 1258

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:410 → 610

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

TIGR01271
Location:11 → 1269

CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

pfam00664
Location:718 → 991

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:96 → 365

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

101948387..102182912 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092967.2 → XP_038948895.1 ATP-binding cassette subfamily C member 4 isoform X2

UniProtKB/Swiss-Prot

F1M3J4, Q6QMG6

UniProtKB/TrEMBL

Q59DL1

Conserved Domains (1) summary

TIGR00957
Location:6 → 1304

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_039092966.2 → XP_038948894.1 ATP-binding cassette subfamily C member 4 isoform X1

UniProtKB/Swiss-Prot

F1M3J4, Q6QMG6

UniProtKB/TrEMBL

A0A8I5YBX7, Q59DL1

Related

ENSRNOP00000076836.1, ENSRNOT00000100006.2

Conserved Domains (1) summary

TIGR00957
Location:6 → 1334

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_063273922.1 → XP_063129992.1 ATP-binding cassette subfamily C member 4 isoform X3

UniProtKB/TrEMBL

A0A8I6A923

Related

ENSRNOP00000089564.1, ENSRNOT00000117189.2
XM_063273925.1 → XP_063129995.1 ATP-binding cassette subfamily C member 4 isoform X6
XM_063273923.1 → XP_063129993.1 ATP-binding cassette subfamily C member 4 isoform X4

UniProtKB/TrEMBL

A6HUG6
XM_063273924.1 → XP_063129994.1 ATP-binding cassette subfamily C member 4 isoform X5

UniProtKB/TrEMBL

A6HUG6