U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Krt6b keratin 6B [ Mus musculus (house mouse) ]

    Gene ID: 16688, updated on 28-Oct-2024

    Summary

    Official Symbol
    Krt6bprovided by MGI
    Official Full Name
    keratin 6Bprovided by MGI
    Primary source
    MGI:MGI:1333768
    See related
    Ensembl:ENSMUSG00000023041 AllianceGenome:MGI:1333768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mK6[b]; Krt2-6b
    Summary
    Predicted to be a structural constituent of skin epidermis. Acts upstream of or within intermediate filament organization; keratinization; and morphogenesis of an epithelium. Predicted to be active in keratin filament. Is expressed in oral epithelium; skin; and tongue. Human ortholog(s) of this gene implicated in focal or diffuse nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Orthologous to human KRT6A (keratin 6A); KRT6B (keratin 6B); and KRT6C (keratin 6C). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in stomach adult (RPKM 16.8), CNS E18 (RPKM 1.8) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Krt6b in Genome Data Viewer
    Location:
    15 F2; 15 56.97 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101584458..101588728, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101676023..101680293, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 6A pseudogene Neighboring gene predicted pseudogene 5478 Neighboring gene STARR-seq mESC enhancer starr_39801 Neighboring gene predicted gene, 49428 Neighboring gene keratin 6A Neighboring gene keratin 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC141272

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intermediate filament organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within keratinization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 6B
    Names
    CK-6B
    K6B
    cytokeratin-6B
    keratin complex 2, basic, gene 6b
    keratin-6-beta
    mK6-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010669.3NP_034799.2  keratin, type II cytoskeletal 6B

      See identical proteins and their annotated locations for NP_034799.2

      Status: VALIDATED

      Source sequence(s)
      AC120787
      Consensus CDS
      CCDS27859.1
      UniProtKB/Swiss-Prot
      Q9Z331
      UniProtKB/TrEMBL
      Q3UV11
      Related
      ENSMUSP00000023786.6, ENSMUST00000023786.7
      Conserved Domains (3) summary
      pfam00038
      Location:151464
      Filament; Intermediate filament protein
      pfam16208
      Location:15148
      Keratin_2_head; Keratin type II head
      cl01888
      Location:377437
      DUF883; Bacterial protein of unknown function (DUF883)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101584458..101588728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)