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    Krt13 keratin 13 [ Mus musculus (house mouse) ]

    Gene ID: 16663, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Krt13provided by MGI
    Official Full Name
    keratin 13provided by MGI
    Primary source
    MGI:MGI:101925
    See related
    Ensembl:ENSMUSG00000044041 AllianceGenome:MGI:101925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K13; CK13; Krt1-13; Krt-1.13
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in lung adult (RPKM 380.7) and stomach adult (RPKM 364.4) See more
    Orthologs
    human all
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    Genomic context

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    See Krt13 in Genome Data Viewer
    Location:
    11 D; 11 63.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100008153..100012392, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100117327..100121566, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 35 Neighboring gene STARR-seq mESC enhancer starr_30712 Neighboring gene keratin 36 Neighboring gene keratin 15 Neighboring gene keratin 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5'-flanking region of the gene. Winter H, et al. Differentiation, 1990 Apr. PMID 1695590
    2. Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway. Shi M, et al. IUBMB Life, 2022 Jun. PMID 35426961
    3. Retinoic acid-induced normal and tumor-associated aberrant expression of the murine keratin K13 gene does not involve a promotor sequence with striking homology to a natural retinoic acid responsive element. Winter H, et al. Carcinogenesis, 1994 Nov. PMID 7525098
    4. Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice. Ahmad A, et al. Cancer Biol Ther, 2010 Nov 15. PMID 20818173, Free PMC Article
    5. The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the circumvallate papilla. Miura H, et al. Neurosci Lett, 2014 Sep 19. PMID 25123441

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway.
      Title: Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway.
    2. Keratin 13 deficiency causes white sponge nevus in mice.
      Title: Keratin 13 deficiency causes white sponge nevus in mice.
    3. denervation caused an increase of Keratin (Krt)13 expression around taste buds
      Title: The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the circumvallate papilla.
    4. K13 cooperates with Myc to promote lymphoma through elevated NF-kappaB.
      Title: Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tongue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 13
    Names
    47 kDa cytokeratin
    CK-13
    cytokeratin 13
    keratin complex 1, acidic, gene 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313949.1 → NP_001300878.1  keratin, type I cytoskeletal 13 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK132640, BQ561384, EH100895
      UniProtKB/Swiss-Prot
      P08730
      Conserved Domains (1) summary
      pfam00038
      Location:1 → 189
      Filament; Intermediate filament protein

    2. NM_010662.2 → NP_034792.1  keratin, type I cytoskeletal 13 isoform 1

      See identical proteins and their annotated locations for NP_034792.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132640, EH100895
      Consensus CDS
      CCDS25409.1
      UniProtKB/Swiss-Prot
      P08730, Q3V176, Q6PAI1
      Related
      ENSMUSP00000007275.3, ENSMUST00000007275.3
      Conserved Domains (1) summary
      pfam00038
      Location:95 → 407
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100008153..100012392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08730.2 GenPept UniProtKB/Swiss-Prot:P08730

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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