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    Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 16534, updated on 2-Nov-2024

    Summary

    Official Symbol
    Kcnn4provided by MGI
    Official Full Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4provided by MGI
    Primary source
    MGI:MGI:1277957
    See related
    Ensembl:ENSMUSG00000054342 AllianceGenome:MGI:1277957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IK1; SK4; KCA4; mIK1; IKCA1; SKCas; mKCa4; KCa3.1; mIKCa1
    Summary
    Enables intermediate conductance calcium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Acts upstream of or within several processes, including cell volume homeostasis; phospholipid translocation; and saliva secretion. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytosol. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including alimentary system; liver; metanephros; nervous system; and skeleton. Human ortholog(s) of this gene implicated in angiosarcoma; cerebral infarction; dehydrated hereditary stomatocytosis 2; hypertension; and myocardial infarction. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 85.0), liver E14.5 (RPKM 56.8) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Kcnn4 in Genome Data Viewer
    Location:
    7 A3; 7 10.37 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24069750..24084635)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24369826..24385212)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Ly6/Plaur domain containing 5 Neighboring gene predicted gene, 38964 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25164989-25165185 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25179546-25179699 Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene immunity related GTPase cinema

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell volume homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macropinocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mononuclear cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatic stellate cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of angiotensin levels in blood ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of renin secretion into blood stream ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within saliva secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in stabilization of membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stabilization of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    intermediate conductance calcium-activated potassium channel protein 4
    Names
    SKCa 4
    SKCa4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163510.2NP_001156982.1  intermediate conductance calcium-activated potassium channel protein 4 isoform a

      See identical proteins and their annotated locations for NP_001156982.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC159140
      Consensus CDS
      CCDS20948.1
      UniProtKB/Swiss-Prot
      O89109, Q3U1J8, Q9CY39
      Related
      ENSMUSP00000133065.2, ENSMUST00000171904.3
      Conserved Domains (3) summary
      smart01053
      Location:302374
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:15121
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:235288
      Ion_trans_2; Ion channel
    2. NM_001412606.1NP_001399535.1  intermediate conductance calcium-activated potassium channel protein 4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 2. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC159140
      UniProtKB/Swiss-Prot
      O89109, Q3U1J8, Q9CY39
    3. NM_001412607.1NP_001399536.1  intermediate conductance calcium-activated potassium channel protein 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC159140
    4. NM_001412608.1NP_001399537.1  intermediate conductance calcium-activated potassium channel protein 4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC159140
    5. NM_001412609.1NP_001399538.1  intermediate conductance calcium-activated potassium channel protein 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC159140
    6. NM_008433.5NP_032459.3  intermediate conductance calcium-activated potassium channel protein 4 isoform a

      See identical proteins and their annotated locations for NP_032459.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC159140
      Consensus CDS
      CCDS20948.1
      UniProtKB/Swiss-Prot
      O89109, Q3U1J8, Q9CY39
      Related
      ENSMUSP00000146012.2, ENSMUST00000205428.2
      Conserved Domains (3) summary
      smart01053
      Location:302374
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:15121
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:235288
      Ion_trans_2; Ion channel

    RNA

    1. NR_182004.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159140
    2. NR_182005.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159140
    3. NR_182006.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159140
    4. NR_182007.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159140

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24069750..24084635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)