Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcna5provided by MGI
Official Full Name: potassium voltage-gated channel, shaker-related subfamily, member 5provided by MGI
Primary source: MGI:MGI:96662
See related: Ensembl:ENSMUSG00000045534 AllianceGenome:MGI:96662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kv1.5
Summary: Enables voltage-gated potassium channel activity. Acts upstream of or within Notch signaling pathway; regulation of membrane potential; and regulation of vasoconstriction. Located in intercalated disc and plasma membrane. Is expressed in several structures, including gut; heart; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in familial atrial fibrillation and pulmonary hypertension. Orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 61.35 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (126509514..126512518, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (126532551..126535555, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration.
Title: Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration.
Intracellular uric acid could stabilize Kv1.5 proteins through phosphorylation of Akt and HSF1 leading to enhanced expression of Hsp70.
Title: Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes.
KV1.5 channels predominantly associate with KVbeta1 and KVbeta2 proteins and that KVbeta2 performs a chaperone function for KV1.5 channels in arterial myocytes, thereby facilitating Kv1alpha trafficking and membrane localization.
Title: Heteromeric complexes of aldo-keto reductase auxiliary K(V)β subunits (AKR6A) regulate sarcolemmal localization of K(V)1.5 in coronary arterial myocytes.
The findings uncover detailed molecular mechanisms underpinning a channelopathy-linked form of atrial fibrillation and emphasize the inevitability of considering extracardiac mechanisms in genetic arrhythmia syndromes.
Title: Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice.
Silencing of Kv1.5 improved endothelium-dependent vasodilatation in thoracic aorta from type 2 diabetes mice.
Title: Suppression of Kv1.5 protects against endothelial apoptosis induced by palmitate and in type 2 diabetes mice.
Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 atrial myocytes.
Title: Molecular Mechanisms Underlying Urate-Induced Enhancement of Kv1.5 Channel Expression in HL-1 Atrial Myocytes.
JAK3 contributes to the regulation of membrane Kv1.5 protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase activity.
Title: Regulation of Voltage-Gated K+ Channel Kv1.5 by the Janus Kinase JAK3.
KV1.5, a DPO-1-sensitive KDR channel, plays a major role in determining microvascular tone and the response to vasoconstrictors and vasodilators.
Title: Diphenyl phosphine oxide-1-sensitive K(+) channels contribute to the vascular tone and reactivity of resistance arteries from brain and skeletal muscle.
Kv1.5 channels in vascular smooth muscle play a critical role in coupling myocardial blood flow to cardiac metabolism.
Title: Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation.
the Kv1.5 subunit has a role in electrical remodeling of preoptic GABAergic neurons
Title: Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L22218 (e-PCR)
- UniSTS:159573

Kcna5 (e-PCR), detects polymorphism
- UniSTS:463210

Kcna5 (e-PCR), detects polymorphism
- UniSTS:498332

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-actinin binding	IEA Inferred from Electronic Annotation more info
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables outward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
NOT enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity involved in SA node cell action potential repolarization	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in SA node cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	IEA Inferred from Electronic Annotation more info
involved_in membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during SA node cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization during SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during atrial cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during bundle of His cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization during bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to hyperoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in intracellular canaliculus	IEA Inferred from Electronic Annotation more info
located_in intracellular canaliculus	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 5

Names: KV1-5; voltage-gated potassium channel subunit Kv1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145983.2 → NP_666095.1 potassium voltage-gated channel subfamily A member 5

See identical proteins and their annotated locations for NP_666095.1

Status: VALIDATED

Source sequence(s)

AF108659, BC021787, CX240838

Consensus CDS

CCDS20554.1

UniProtKB/Swiss-Prot

Q61762, Q9Z1R6

Related

ENSMUSP00000055673.4, ENSMUST00000060972.5

Conserved Domains (4) summary

smart00225
Location:113 → 207

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:305 → 515

Ion_trans; Ion transport protein

pfam02214
Location:113 → 204

BTB_2; BTB/POZ domain

pfam07885
Location:429 → 506

Ion_trans_2; Ion channel