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    ZDHHC15 zinc finger DHHC-type palmitoyltransferase 15 [ Homo sapiens (human) ]

    Gene ID: 158866, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZDHHC15provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 15provided by HGNC
    Primary source
    HGNC:HGNC:20342
    See related
    Ensembl:ENSG00000102383 MIM:300576; AllianceGenome:HGNC:20342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRX91; DHHC15
    Summary
    The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in brain (RPKM 1.4), thyroid (RPKM 0.9) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZDHHC15 in Genome Data Viewer
    Location:
    Xq13.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (75368427..75523037, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (73802127..73956714, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (74588262..74742872, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905200 Neighboring gene uracil phosphoribosyltransferase homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29773 Neighboring gene TERF1 pseudogene 7 Neighboring gene ribosomal protein L21 pseudogene 134 Neighboring gene uncharacterized LOC107985664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:74780229-74780730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:74780731-74781230 Neighboring gene PEST containing nuclear protein pseudogene 4 Neighboring gene BRAF pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZDHHC15 as a candidate gene for autism spectrum disorder. Casellas-Vidal D, et al. Am J Med Genet A, 2023 Apr. PMID 36565021
    2. Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. Mansouri MR, et al. Eur J Hum Genet, 2005 Aug. PMID 15915161
    3. ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma. Liu ZY, et al. BMC Cancer, 2023 May 9. PMID 37161425, Free PMC Article
    4. Palmitoylation controls recycling in lysosomal sorting and trafficking. McCormick PJ, et al. Traffic, 2008 Nov. PMID 18817523, Free PMC Article
    5. Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Greaves J, et al. Proc Natl Acad Sci U S A, 2017 Feb 21. PMID 28167757, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma.
      Title: ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma.
    2. ZDHHC15 as a candidate gene for autism spectrum disorder.
      Title: ZDHHC15 as a candidate gene for autism spectrum disorder.
    3. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.
      Title: Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-07-25)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-07-25)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31812, MGC119974, MGC119975, MGC119976

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-cysteine S-stearoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to postsynapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic vesicle maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC15
    Names
    DHHC-15
    acyltransferase ZDHHC15
    zinc finger DHHC domain-containing protein 15
    zinc finger DHHC-type containing 15
    zinc finger, DHHC domain containing 15
    NP_001139728.1
    NP_001139729.1
    NP_659406.1
    XP_006724687.1
    XP_016884785.1
    XP_024308110.1
    XP_047297821.1
    XP_047297822.1
    XP_047297823.1
    XP_047297824.1
    XP_047297825.1
    XP_054182523.1
    XP_054182524.1
    XP_054182525.1
    XP_054182526.1
    XP_054182527.1
    XP_054182528.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012974.1 RefSeqGene

      Range
      5466..160076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001146256.2 → NP_001139728.1  palmitoyltransferase ZDHHC15 isoform 2

      See identical proteins and their annotated locations for NP_001139728.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is lacking an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing a 9 aa segment compared to isoform 1.
      Source sequence(s)
      AK056374, AK122885, AK123754, AK128587, AL137013, BQ028106
      Consensus CDS
      CCDS55454.1
      UniProtKB/TrEMBL
      B3KY34
      Related
      ENSP00000445420.1, ENST00000541184.1
      Conserved Domains (1) summary
      cl19890
      Location:117 → 299
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_001146257.2 → NP_001139729.1  palmitoyltransferase ZDHHC15 isoform 3

      See identical proteins and their annotated locations for NP_001139729.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is lacking an in-frame coding exon and differs at the 3' end compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC020717, AY358786
      UniProtKB/Swiss-Prot
      Q96MV8

    3. NM_144969.3 → NP_659406.1  palmitoyltransferase ZDHHC15 isoform 1

      See identical proteins and their annotated locations for NP_659406.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK056374, AK122885, AK123754, AK128587, AL137013, BQ028106
      Consensus CDS
      CCDS14430.1
      UniProtKB/Swiss-Prot
      B3KVG7, Q3SY30, Q6UWH3, Q96MV8
      UniProtKB/TrEMBL
      B3KY34
      Related
      ENSP00000362465.3, ENST00000373367.8
      Conserved Domains (1) summary
      cl19890
      Location:126 → 308
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      75368427..75523037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452342.1 → XP_024308110.1  palmitoyltransferase ZDHHC15 isoform X5

      Conserved Domains (1) summary
      cl19890
      Location:18 → 200
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_047441867.1 → XP_047297823.1  palmitoyltransferase ZDHHC15 isoform X3

    3. XM_047441866.1 → XP_047297822.1  palmitoyltransferase ZDHHC15 isoform X3

    4. XM_006724624.5 → XP_006724687.1  palmitoyltransferase ZDHHC15 isoform X1

      See identical proteins and their annotated locations for XP_006724687.1

      UniProtKB/Swiss-Prot
      B3KVG7, Q3SY30, Q6UWH3, Q96MV8
      UniProtKB/TrEMBL
      B3KY34
      Conserved Domains (1) summary
      cl19890
      Location:126 → 308
      zf-DHHC; DHHC palmitoyltransferase

    5. XM_047441865.1 → XP_047297821.1  palmitoyltransferase ZDHHC15 isoform X1

      UniProtKB/Swiss-Prot
      B3KVG7, Q3SY30, Q6UWH3, Q96MV8

    6. XM_047441869.1 → XP_047297825.1  palmitoyltransferase ZDHHC15 isoform X6

    7. XM_047441868.1 → XP_047297824.1  palmitoyltransferase ZDHHC15 isoform X4

    8. XM_017029296.3 → XP_016884785.1  palmitoyltransferase ZDHHC15 isoform X2

      UniProtKB/TrEMBL
      B3KY34

    RNA

    1. XR_001755658.3 RNA Sequence

    2. XR_938393.3 RNA Sequence

    3. XR_007068181.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      73802127..73956714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326552.1 → XP_054182527.1  palmitoyltransferase ZDHHC15 isoform X5

    2. XM_054326549.1 → XP_054182524.1  palmitoyltransferase ZDHHC15 isoform X3

    3. XM_054326548.1 → XP_054182523.1  palmitoyltransferase ZDHHC15 isoform X1

      UniProtKB/Swiss-Prot
      B3KVG7, Q3SY30, Q6UWH3, Q96MV8

    4. XM_054326553.1 → XP_054182528.1  palmitoyltransferase ZDHHC15 isoform X6

    5. XM_054326551.1 → XP_054182526.1  palmitoyltransferase ZDHHC15 isoform X4

    6. XM_054326550.1 → XP_054182525.1  palmitoyltransferase ZDHHC15 isoform X2

    RNA

    1. XR_008485456.1 RNA Sequence

    2. XR_008485455.1 RNA Sequence

    3. XR_008485457.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96MV8.1 GenPept UniProtKB/Swiss-Prot:Q96MV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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