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    LRATD2 LRAT domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 157638, updated on 28-Oct-2024

    Summary

    Official Symbol
    LRATD2provided by HGNC
    Official Full Name
    LRAT domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:24166
    See related
    Ensembl:ENSG00000168672 MIM:609483; AllianceGenome:HGNC:24166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NSE2; FAM84B; BCMP101
    Summary
    Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 18.2), salivary gland (RPKM 11.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LRATD2 in Genome Data Viewer
    Location:
    8q24.21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (126552443..126558478, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (127679604..127685649, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (127564688..127570723, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375750 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:127534858-127535674 Neighboring gene RNA, U6 small nuclear 869, pseudogene Neighboring gene MPRA-validated peak7170 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:127559131-127559886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:127564099-127564608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19521 Neighboring gene uncharacterized LOC105375751 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127570125-127570961 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127591655-127592462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127592463-127593270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127593271-127594077 Neighboring gene zinc finger protein 724-like Neighboring gene Sharpr-MPRA regulatory region 547 Neighboring gene RNA, U11 small nuclear 4, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein LRATD2
    Names
    breast cancer membrane protein 101
    breast cancer membrane-associated protein 101
    family with sequence similarity 84 member B
    neurological/sensory 2
    protein FAM84B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174911.5NP_777571.1  protein LRATD2

      See identical proteins and their annotated locations for NP_777571.1

      Status: VALIDATED

      Source sequence(s)
      AC084116, AK074285
      Consensus CDS
      CCDS6358.1
      UniProtKB/Swiss-Prot
      Q96KN1
      UniProtKB/TrEMBL
      A8K9V9
      Related
      ENSP00000302578.3, ENST00000304916.4
      Conserved Domains (1) summary
      cl21534
      Location:130212
      NLPC_P60; NlpC/P60 family

    RNA

    1. NR_156466.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084116, BE221581, BE326721, CB985735, CX788171

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      126552443..126558478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013107.3XP_016868596.1  protein LRATD2 isoform X1

      UniProtKB/Swiss-Prot
      Q96KN1
      UniProtKB/TrEMBL
      A8K9V9
      Conserved Domains (1) summary
      cl21534
      Location:130212
      NLPC_P60; NlpC/P60 family
    2. XM_017013108.3XP_016868597.1  protein LRATD2 isoform X2

      UniProtKB/TrEMBL
      A8K9V9
      Conserved Domains (1) summary
      cl21534
      Location:112194
      NLPC_P60; NlpC/P60 family

    RNA

    1. XR_007060705.1 RNA Sequence

    2. XR_007060704.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      127679604..127685649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359813.1XP_054215788.1  protein LRATD2 isoform X2

    RNA

    1. XR_008487812.1 RNA Sequence