Htr1b 5-hydroxytryptamine (serotonin) receptor 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr1bprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 1Bprovided by MGI
Primary source: MGI:MGI:96274
See related: Ensembl:ENSMUSG00000049511 AllianceGenome:MGI:96274
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5-HT-1B
Summary: Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in negative regulation of serotonin secretion and phospholipase C-activating serotonin receptor signaling pathway. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; bone remodeling; and response to toxic substance. Located in cytoplasm and plasma membrane. Part of G protein-coupled serotonin receptor complex. Is active in presynaptic membrane and serotonergic synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; gonad; and immune system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 9 E1; 9 44.61 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (81510344..81515885, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (81628291..81633832, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brainstem serotonin neurons selectively gate retinal information flow to thalamus.
Title: Brainstem serotonin neurons selectively gate retinal information flow to thalamus.
Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice.
Title: Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice.
Depressive-like state sensitizes 5-HT1A and 5-HT1B auto-receptors in the dorsal raphe nucleus sub-system.
Title: Depressive-like state sensitizes 5-HT(1A) and 5-HT(1B) auto-receptors in the dorsal raphe nucleus sub-system.
Consistent with previous studies that have optogenetically inhibited vHPC-mPFC projections, activating prefrontal 5-HT1B receptors suppressed theta-frequency mPFC activity (4-12 Hz), and reduced avoidance of anxiogenic regions in the elevated plus maze
Title: Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs.
we showed that gravity changes induced differential modulation of gene expression of BDNF and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
Title: Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain.
Mice lacking 5-HT1B autoreceptors displayed the expected increases in extracellular serotonin levels in the ventral hippocampus following administration of a selective serotonin reuptake inhibitor.
Title: A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.
5-HT1B receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in pulmonary arterial hypertension.
Title: Serotonin Signaling Through the 5-HT(1B) Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension.
Data suggest that pharmacological stimulation of serotonin 5Ht1b receptor enhances up-regulation of plasma Glp1 (glucagon-like peptide 1) induced by Dpp4 (dipeptidylpeptidase 4) inhibition independently of feeding and also improves glucose tolerance.
Title: Pharmacological stimulation of serotonin 5-HT1B receptors enhances increases in plasma active glucagon-like peptide-1 levels induced by dipeptidyl peptidase-4 inhibition independently of feeding in mice.
5-HT1B Knockout and pharmacologic 5-HT1B antagonism both attenuated locomotor hyperactivity in dopamine transporter Knockout mice.
Title: Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout.
5-HT1BR was validated as a target for miRNA-96. Transfection of precursor miRNA-96 into hPASMCs reduced 5-HT1BR expression and inhibited serotonin-induced proliferation in pulmonary hypertension development.
Title: A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (9) 1 citation

General gene information

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Markers

Htr1b (e-PCR), detects polymorphism
- UniSTS:143414

UniSTS:143415 (e-PCR)
- UniSTS:143415

Htr1b (e-PCR), detects polymorphism
- UniSTS:143415

UniSTS:491331 (e-PCR)
- UniSTS:491331

GDB:580614 (e-PCR)
- UniSTS:157841

PMC311033P3 (e-PCR)
- UniSTS:272841

PMC166422P1 (e-PCR)
- UniSTS:271594

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables Gi/o-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	IDA Inferred from Direct Assay more info	PubMed
enables serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bone remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to alkaloid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to alkaloid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in drinking behavior	IEA Inferred from Electronic Annotation more info
involved_in drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gamma-aminobutyric acid secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to mineralocorticoid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to toxic substance	IDA Inferred from Direct Assay more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in serotonergic synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1B

Names: 5-HT1B receptor; 5-HT<1B> receptor; serotonin receptor 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410237.1 → NP_001397166.1 5-hydroxytryptamine receptor 1B

Status: VALIDATED

Source sequence(s)

AC158998

UniProtKB/Swiss-Prot

P28334

UniProtKB/TrEMBL

Q0VES5
NM_010482.2 → NP_034612.1 5-hydroxytryptamine receptor 1B

See identical proteins and their annotated locations for NP_034612.1

Status: VALIDATED

Source sequence(s)

AC158998

Consensus CDS

CCDS23370.1

UniProtKB/Swiss-Prot

P28334

UniProtKB/TrEMBL

Q0VES5

Related

ENSMUSP00000139389.2, ENSMUST00000183482.2

Conserved Domains (1) summary

cd15333
Location:42 → 376

7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors