B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: B4galt1provided by MGI
Official Full Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1provided by MGI
Primary source: MGI:MGI:95705
See related: Ensembl:ENSMUSG00000028413 AllianceGenome:MGI:95705
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GalT; Ggtb; Ggtb2; b4Gal-T1; B-1,4-GalT; B-1,4-GalT1; beta4Gal-T1; beta-1,4-GalT; beta-1,4-GalT1
Summary: This gene encodes two distinct enzyme isoforms, a long membrane-bound form and a short soluble form. These alternate isoforms are thought to be produced through alternative nested transcription initiation and different in-frame start codon usage. These enzymes catalyze the transfer of galactose to acceptor sugars, such as N-acetylglucosamine and glucose. The long form of this enzyme is localized to the trans-Golgi membrane and is involved in glycoconjugate biosynthesis. The short form functions in lactose biosynthesis though formation of a heterodimer with alpha-lactalbumin. [provided by RefSeq, Nov 2012]
Expression: Ubiquitous expression in adrenal adult (RPKM 28.6), ovary adult (RPKM 25.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 20.46 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (40804602..40855711, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (40804602..40853984, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-1,4-Galactosyltransferase 1 protects against cerebral ischemia injury in mice by suppressing ferroptosis via the TAZ/Nrf2/HO-1 signaling pathway.
Title: β-1,4-Galactosyltransferase 1 protects against cerebral ischemia injury in mice by suppressing ferroptosis via the TAZ/Nrf2/HO-1 signaling pathway.
Transcriptional Mechanism of the Mouse beta4-Galactosyltransferase 6 Gene in Mouse Neuroblastoma Cell Line Neuro-2a.
Title: Transcriptional Mechanism of the Mouse β4-Galactosyltransferase 6 Gene in Mouse Neuroblastoma Cell Line Neuro-2a.
MicroRNA-15a/beta1,4-GalT-I axis contributes to cartilage degeneration via NF-kappaB signaling in osteoarthritis.
Title: MicroRNA-15a/β1,4-GalT-I axis contributes to cartilage degeneration via NF-κB signaling in osteoarthritis.
B-cell-specific ablation of beta-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice.
Title: B-cell-specific ablation of β-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice.
Aberration of Serum and Tissue N-Glycans in Mouse beta1,4-GalT1 Y286L Mutant Variants.
Title: Aberration of Serum and Tissue N-Glycans in Mouse β1,4-GalT1 Y286L Mutant Variants.
beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Title: β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models.
Title: Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models.
The loss of the long GalT-I isoform also leads to a loss of actin stress fibers, focal adhesions and rac GTPase activation.
Title: Mouse fibroblasts null for the long isoform of β1,4-galactosyltransferase-I show defective cell-matrix interactions.
beta4GalT1 can regulate N-glycans of CXCR3 in RA. N-glycans of CXCR3 affects CXCL10/CXCR3 ligand-binding which enhancing fibroblast-like synoviocytes invasion.
Title: The β4GalT1 affects the fibroblast-like synoviocytes invasion in rheumatoid arthritis by modifying N-linked glycosylation of CXCR3.
Beta 1,4-galactosyltransferase I possibly regulate mutual uterus-embryo adhesion and embryo implantation by regulating cell surface Le(Y) glycan expression.
Title: Regulatory function of β1,4-galactosyltransferase I expression on Lewis-Y glycan and embryo implantation.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D00314 (e-PCR)
- UniSTS:178986

NoName (e-PCR)
- UniSTS:548447

B4galt1 (e-PCR), detects polymorphism
- UniSTS:546681

RH124579 (e-PCR)
- UniSTS:161401

AW743448 (e-PCR)
- UniSTS:207612

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyllactosamine synthase activity	IEA Inferred from Electronic Annotation more info
enables N-acetyllactosamine synthase activity	ISO Inferred from Sequence Orthology more info
enables UDP-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lactose synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lactose synthase activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within binding of sperm to zona pellucida	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within development of secondary sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within galactose metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycoprotein biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lactose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligosaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within penetration of zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circulating fibrinogen levels	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circulating fibrinogen levels	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi trans cisterna	IEA Inferred from Electronic Annotation more info
located_in Golgi trans cisterna	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in desmosome	IEA Inferred from Electronic Annotation more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-1,4-galactosyltransferase 1

Names: N-acetyllactosamine synthase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1; b1,4-Galactosyltransferase I; beta-1,4-GalTase 1; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; galactosyltransferase 2 beta 1, 4; glycoprotein galactosyltransferase beta 1, 4; lactose synthase A protein; nal synthase; neolactotriaosylceramide beta-1,4-galactosyltransferase

NP_001365448.1

EC 2.4.1.22

EC 2.4.1.275

EC 2.4.1.38

EC 2.4.1.90

NP_071641.1

EC 2.4.1.22

EC 2.4.1.275

EC 2.4.1.38

EC 2.4.1.90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378519.2 → NP_001365448.1 beta-1,4-galactosyltransferase 1 isoform 2

Status: REVIEWED

Source sequence(s)

AEKQ02033059, AL833775

UniProtKB/TrEMBL

B1AXY5, Q3TJS1

Conserved Domains (1) summary

cd00899
Location:163 → 381

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
NM_022305.6 → NP_071641.1 beta-1,4-galactosyltransferase 1 isoform 1

See identical proteins and their annotated locations for NP_071641.1

Status: REVIEWED

Source sequence(s)

AEKQ02033059, AL833775

Consensus CDS

CCDS18051.1

UniProtKB/Swiss-Prot

P15535

UniProtKB/TrEMBL

B1AXY5, Q3U478

Related

ENSMUSP00000030121.7, ENSMUST00000030121.13

Conserved Domains (1) summary

cd00899
Location:176 → 394

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids