U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Usp15 ubiquitin specific peptidase 15 [ Mus musculus (house mouse) ]

    Gene ID: 14479, updated on 28-Oct-2024

    Summary

    Official Symbol
    Usp15provided by MGI
    Official Full Name
    ubiquitin specific peptidase 15provided by MGI
    Primary source
    MGI:MGI:101857
    See related
    Ensembl:ENSMUSG00000020124 AllianceGenome:MGI:101857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcap18; 4921514G19Rik; E430033I05Rik
    Summary
    The protein encoded by this gene is a member of the large ubiquitin specific protease (Usp) family of proteins. These proteins are known to cleave ubiquitin, and contain a conserved cysteine residue (Cys box) and two conserved histidine residues (His box) that are thought to form part of the active site of the protease. This protein has been shown to cleave both the ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This protein is thought to regulate many cellular processes through its deubiquitination activity, including the transforming growth factor beta (TGF-beta) pathway. Cardiac-specific overexpression of the human ortholog of this gene in mice causes enlargement of the heart that is more pronounced in the atrium than in the ventricle. This gene has two pseudogenes on chromosome 14. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms.[provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.0), placenta adult (RPKM 8.8) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Usp15 in Genome Data Viewer
    Location:
    10 D2; 10 72.31 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (122940911..123032924, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (123105006..123197281, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5196 Neighboring gene STARR-positive B cell enhancer ABC_E9356 Neighboring gene STARR-positive B cell enhancer ABC_E10651 Neighboring gene microRNA let7i Neighboring gene MON2 homolog, regulator of endosome to Golgi trafficking Neighboring gene STARR-positive B cell enhancer ABC_E6936 Neighboring gene STARR-positive B cell enhancer ABC_E9134 Neighboring gene STARR-positive B cell enhancer ABC_E11464 Neighboring gene predicted gene 4129 Neighboring gene predicted gene, 36628 Neighboring gene TAFA chemokine like family member 2 Neighboring gene predicted gene, 22958

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-modified histone reader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-modified histone reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monoubiquitinated protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoubiquitinated protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of antifungal innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of antifungal innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of RIG-I signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K27-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K27-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription elongation-coupled chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transcription elongation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription elongation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 15
    Names
    deubiquitinating enzyme 15
    granule cell antiserum positive 18
    ubiquitin thioesterase 15
    ubiquitin thiolesterase 15
    ubiquitin-specific-processing protease 15
    NP_001288557.1
    NP_081880.2
    XP_006513288.1
    XP_006513289.1
    XP_006513290.1
    XP_006513291.1
    XP_036011508.1
    XP_036011509.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301628.2NP_001288557.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 2

      See identical proteins and their annotated locations for NP_001288557.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC153021, AC158802
      Consensus CDS
      CCDS88095.1
      UniProtKB/Swiss-Prot
      Q8R5H1
      Related
      ENSMUSP00000020334.9, ENSMUST00000020334.9
      Conserved Domains (6) summary
      smart00695
      Location:24121
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:12903
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:755902
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:261446
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:462568
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:135222
      Ubiquitin_3; Ubiquitin-like domain
    2. NM_001428484.1NP_001415413.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC153021, AC158802
    3. NM_001428485.1NP_001415414.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC153021, AC158802
    4. NM_001428486.1NP_001415415.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC153021, AC158802
    5. NM_001428487.1NP_001415416.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC153021, AC158802
    6. NM_027604.5NP_081880.2  ubiquitin carboxyl-terminal hydrolase 15 isoform 1

      See identical proteins and their annotated locations for NP_081880.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC153021, AC158802
      Consensus CDS
      CCDS24217.1
      UniProtKB/Swiss-Prot
      Q3TGF5, Q3TTB2, Q3UL25, Q3UZH0, Q80TY6, Q80UK9, Q8R5H1
      Related
      ENSMUSP00000151244.2, ENSMUST00000220377.2
      Conserved Domains (6) summary
      smart00695
      Location:24121
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:12932
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:784931
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:290475
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:491597
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:135222
      Ubiquitin_3; Ubiquitin-like domain

    RNA

    1. NR_190377.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC153021, AC158802
    2. NR_190378.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC153021, AC158802
    3. NR_190379.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC158802

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      122940911..123032924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155616.1XP_036011509.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X3

      Conserved Domains (1) summary
      COG5560
      Location:34683
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    2. XM_036155615.1XP_036011508.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X1

      Conserved Domains (1) summary
      COG5560
      Location:63712
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    3. XM_006513227.5XP_006513290.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X5

      Conserved Domains (1) summary
      COG5560
      Location:1633
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    4. XM_006513226.5XP_006513289.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X4

      Conserved Domains (1) summary
      COG5560
      Location:32681
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    5. XM_006513225.5XP_006513288.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X2

      Conserved Domains (1) summary
      COG5560
      Location:41690
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    6. XM_006513228.5XP_006513291.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X6

      UniProtKB/TrEMBL
      Q3TPH3
      Conserved Domains (2) summary
      smart00695
      Location:24121
      DUSP; Domain in ubiquitin-specific proteases
      pfam14836
      Location:135222
      Ubiquitin_3; Ubiquitin-like domain

    RNA

    1. XR_004936099.1 RNA Sequence

    2. XR_380365.5 RNA Sequence