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Fgfr1 fibroblast growth factor receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 14182, updated on 14-Nov-2024

Summary

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Official Symbol: Fgfr1provided by MGI
Official Full Name: fibroblast growth factor receptor 1provided by MGI
Primary source: MGI:MGI:95522
See related: Ensembl:ENSMUSG00000031565 AllianceGenome:MGI:95522
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FLG; Fr1; MFR; Eask; Hspy; Flt-2; c-fgr; FGFR-I; Fgfr-1; bFGF-R-1
Summary: Enables SH2 domain binding activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor activity. Involved in several processes, including cementum mineralization; diphosphate metabolic process; and forebrain development. Acts upstream of or within several processes, including ear development; positive regulation of cell population proliferation; and regulation of animal organ morphogenesis. Located in plasma membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Pfeiffer syndrome; atopic dermatitis; and otitis media. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 38.2), adrenal adult (RPKM 35.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

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See Fgfr1 in Genome Data Viewer

Location:: 8 A2; 8 14.12 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (26008808..26067819)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (25518759..25575718)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tanycyte radial morphology and proliferation are influenced by fibroblast growth factor receptor 1 and high-fat diet.
Title: Tanycyte radial morphology and proliferation are influenced by fibroblast growth factor receptor 1 and high-fat diet.
MiRNA-470-5p suppresses epithelial-mesenchymal transition of embryonic palatal shelf epithelial cells by targeting Fgfr1 during palatogenesis.
Title: MiRNA-470-5p suppresses epithelial-mesenchymal transition of embryonic palatal shelf epithelial cells by targeting Fgfr1 during palatogenesis.
Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice.
Title: Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice.
Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death.
Title: Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death.
Fgfr1 deficiency in osteocytes leads to increased bone mass by enhancing Wnt/beta-catenin signaling.
Title: Fgfr1 deficiency in osteocytes leads to increased bone mass by enhancing Wnt/β-catenin signaling.
FGF21-FGFR1 controls mitochondrial homeostasis in cardiomyocytes by modulating the degradation of OPA1.
Title: FGF21-FGFR1 controls mitochondrial homeostasis in cardiomyocytes by modulating the degradation of OPA1.
Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1.
Title: Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1.
Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryo.
Title: Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryo.
Convergent biological pathways underlying the Kallmann syndrome-linked genes Hs6st1 and Fgfr1.
Title: Convergent biological pathways underlying the Kallmann syndrome-linked genes Hs6st1 and Fgfr1.
TNFAIP3 mediates FGFR1 activation-induced breast cancer angiogenesis by promoting VEGFA expression and secretion.
Title: TNFAIP3 mediates FGFR1 activation-induced breast cancer angiogenesis by promoting VEGFA expression and secretion.

Submit: New GeneRIF Correction See all GeneRIFs (210)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Spontaneous (1)
Targeted (46) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW208770 (e-PCR)
- UniSTS:179720

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:507932

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:534560

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:547629

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:273725

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:273726

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:547903

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:464709

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:265557

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:480341

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:265558

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:463446

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:265559

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:464787

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:464788

PMC195961P1 (e-PCR)
- UniSTS:271787

MARC_14569-14570:1009480763:3 (e-PCR)
- UniSTS:267706

PMC154461P1 (e-PCR)
- UniSTS:271314

NoName (e-PCR)
- UniSTS:548571

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:143097

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:143098

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:143099

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:143100

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables receptor-receptor interaction	IEA Inferred from Electronic Annotation more info
enables receptor-receptor interaction	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within auditory receptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell projection assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cementum mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in cementum mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in diphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung-associated mesenchyme development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of mesenchymal cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within middle ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in orbitofrontal cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within organ induction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within outer ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within paraxial mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of parathyroid hormone secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in postnatal olfactory bulb interneuron migration	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lateral mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of phosphate transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of phosphorus metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to sodium phosphate	IDA Inferred from Direct Assay more info	PubMed
involved_in response to sodium phosphate	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tangential migration from the subventricular zone to the olfactory bulb	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureteric bud development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis involved in coronary vascular morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in ventricular zone neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vitamin D3 metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor receptor 1

Names: basic fibroblast growth factor receptor 1; proto-oncogene c-Fgr

NP_001073377.1

EC 2.7.10.1

NP_001073378.1

EC 2.7.10.1

NP_034336.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079908.3 → NP_001073377.1 fibroblast growth factor receptor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001073377.1

Status: VALIDATED

Source sequence(s)

AC160526

Consensus CDS

CCDS57614.1

UniProtKB/TrEMBL

Q60818, Q8CIM9

Related

ENSMUSP00000113909.3, ENSMUST00000117179.9

Conserved Domains (7) summary

cd04973
Location:40 → 118

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd04974
Location:268 → 357

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:161 → 245

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:260 → 356

IG_like; Immunoglobulin like

pfam07679
Location:158 → 245

I-set; Immunoglobulin I-set domain

cd05098
Location:462 → 763

PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

pfam07714
Location:476 → 752

Pkinase_Tyr; Protein tyrosine kinase
NM_001079909.3 → NP_001073378.1 fibroblast growth factor receptor 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001073378.1

Status: VALIDATED

Source sequence(s)

AC160526

Consensus CDS

CCDS40304.1

UniProtKB/TrEMBL

Q60818

Related

ENSMUSP00000113855.3, ENSMUST00000119398.10

Conserved Domains (6) summary

cd04974
Location:181 → 270

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:74 → 158

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:173 → 269

IG_like; Immunoglobulin like

pfam07679
Location:71 → 158

I-set; Immunoglobulin I-set domain

cd05098
Location:375 → 676

PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

pfam07714
Location:389 → 665

Pkinase_Tyr; Protein tyrosine kinase
NM_010206.4 → NP_034336.2 fibroblast growth factor receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_034336.2

Status: VALIDATED

Source sequence(s)

AC160526

Consensus CDS

CCDS52526.1

UniProtKB/Swiss-Prot

E9Q2P4, P16092, Q01736, Q60830, Q61562, Q80T10, Q8CFK8, Q9QZM7

UniProtKB/TrEMBL

Q60818

Related

ENSMUSP00000081041.6, ENSMUST00000084027.13

Conserved Domains (7) summary

cd04973
Location:40 → 118

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd04974
Location:270 → 359

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:163 → 247

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:262 → 358

IG_like; Immunoglobulin like

pfam07679
Location:160 → 247

I-set; Immunoglobulin I-set domain

cd05098
Location:464 → 765

PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

pfam07714
Location:478 → 754

Pkinase_Tyr; Protein tyrosine kinase