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    Fgf13 fibroblast growth factor 13 [ Mus musculus (house mouse) ]

    Gene ID: 14168, updated on 28-Oct-2024

    Summary

    Official Symbol
    Fgf13provided by MGI
    Official Full Name
    fibroblast growth factor 13provided by MGI
    Primary source
    MGI:MGI:109178
    See related
    Ensembl:ENSMUSG00000031137 AllianceGenome:MGI:109178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fhf2; Fgf1c
    Summary
    Enables sodium channel regulator activity; transmembrane transporter binding activity; and tubulin binding activity. Involved in several processes, including learning or memory; negative regulation of cellular component organization; and nervous system development. Acts upstream of or within branching morphogenesis of a nerve; learning or memory; and neurogenesis. Located in several cellular components, including growth cone; intercalated disc; and lateral plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; peripheral nervous system; and sensory organ. Used to study intellectual disability. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 90 and non-syndromic X-linked intellectual disability. Orthologous to human FGF13 (fibroblast growth factor 13). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in CNS E18 (RPKM 22.7), frontal lobe adult (RPKM 16.1) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fgf13 in Genome Data Viewer
    Location:
    X A6; X 33.31 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (58107499..58630932, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (59062139..59585572, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene MAGE family member A13 Neighboring gene microRNA 504 Neighboring gene predicted gene, 26487 Neighboring gene histidyl-tRNA synthetase 2, mitochondrial (putative) pseudogene Neighboring gene predicted gene, 39518 Neighboring gene STARR-seq mESC enhancer starr_47232 Neighboring gene STARR-seq mESC enhancer starr_47233 Neighboring gene STARR-seq mESC enhancer starr_47234 Neighboring gene STARR-seq mESC enhancer starr_47235 Neighboring gene predicted gene, 36631 Neighboring gene STARR-seq mESC enhancer starr_47236 Neighboring gene synaptophysin-like protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebral cortex cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in establishment of neuroblast polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of neuroblast polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inhibitory synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of voltage-gated sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 13
    Names
    fibroblast growth factor 1c
    fibroblast growth factor homologous factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290414.1NP_001277343.1  fibroblast growth factor 13 isoform 2

      See identical proteins and their annotated locations for NP_001277343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1. Variants 2 and 5-8 all encode the same isoform (2).
      Source sequence(s)
      AL669891, AL670091, AL672247, AL713968
      Conserved Domains (1) summary
      smart00442
      Location:77207
      FGF; Acidic and basic fibroblast growth factor family
    2. NM_001290415.1NP_001277344.1  fibroblast growth factor 13 isoform 3

      See identical proteins and their annotated locations for NP_001277344.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK141848, BC018238, CD776909, CJ064772
      Consensus CDS
      CCDS72383.1
      UniProtKB/TrEMBL
      B1AU20
      Related
      ENSMUSP00000113206.2, ENSMUST00000119306.2
      Conserved Domains (1) summary
      smart00442
      Location:14144
      FGF; Acidic and basic fibroblast growth factor family
    3. NM_001356335.1NP_001343264.1  fibroblast growth factor 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL713968
      UniProtKB/TrEMBL
      B1AU20
      Conserved Domains (1) summary
      smart00442
      Location:21151
      FGF; Acidic and basic fibroblast growth factor family
    4. NM_001411971.1NP_001398900.1  fibroblast growth factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL672247, AL713968
    5. NM_001411972.1NP_001398901.1  fibroblast growth factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL672247, AL713968
    6. NM_001411973.1NP_001398902.1  fibroblast growth factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL672247, AL713968
    7. NM_001425598.1NP_001412527.1  fibroblast growth factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL672247, AL713968
    8. NM_001425599.1NP_001412528.1  fibroblast growth factor 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL713968
    9. NM_001425600.1NP_001412529.1  fibroblast growth factor 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL713968
    10. NM_001425601.1NP_001412530.1  fibroblast growth factor 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL713968
      Related
      ENSMUSP00000113639.2, ENSMUST00000119833.8
    11. NM_010200.3NP_034330.2  fibroblast growth factor 13 isoform 1

      See identical proteins and their annotated locations for NP_034330.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC018238, CD776909
      Consensus CDS
      CCDS30157.1
      UniProtKB/Swiss-Prot
      B1AU21, O35338, P70377, Q3UR31, Q8VCY9, Q9JLA5
      UniProtKB/TrEMBL
      A0A7U3JW69
      Related
      ENSMUSP00000033473.6, ENSMUST00000033473.12
      Conserved Domains (1) summary
      smart00442
      Location:67197
      FGF; Acidic and basic fibroblast growth factor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      58107499..58630932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527799.3XP_006527862.1  fibroblast growth factor 13 isoform X3

      UniProtKB/TrEMBL
      B1AU20
      Conserved Domains (1) summary
      smart00442
      Location:11141
      FGF; Acidic and basic fibroblast growth factor family