Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcer2aprovided by MGI
Official Full Name: Fc receptor, IgE, low affinity II, alpha polypeptideprovided by MGI
Primary source: MGI:MGI:95497
See related: Ensembl:ENSMUSG00000005540 AllianceGenome:MGI:95497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD23; Fce2; Fcer2; Ly-42
Summary: Predicted to enable several functions, including IgE binding activity; low-affinity IgE receptor activity; and protease binding activity. Acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin. Located in external side of plasma membrane. Is expressed in lymph node; spleen; and thymus. Orthologous to human FCER2 (Fc epsilon receptor II). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 10.2), mammary gland adult (RPKM 7.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 1.92 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (3730280..3744174, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (3680280..3694174, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IgE-ICs are noninflammatory through reduced engagement by FcepsilonRI but increased targeting of the CD23 pathway.
Title: CD23 provides a noninflammatory pathway for IgE-allergen complexes.
Human and murine P2X7 activation induces the rapid shedding of CD23 from B cells, with a potential role for ADAM10 in this process.
Title: Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.
CD23 was shown to be sorted in an ADAM10-dependent manner into exosomes.
Title: CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes.
B cells captured IgE by direct binding to the low-affinity IgE receptor, CD23.
Title: Murine B cells regulate serum IgE levels in a CD23-dependent manner.
CD23 is an important regulatory factor for IgE production
Title: 129/SvJ mice have mutated CD23 and hyper IgE.
BAFF does not preferentially induce the expression of CD23 or CD21.
Title: Analysis of the regulatory role of BAFF in controlling the expression of CD21 and CD23.
After exposure for 10 consecutive days to nebulized ovalbumin challenge, mice with disrupted Fc epsilon RI alpha subunit show low response to electrical field stimulation, less airway inflammation and goblet cell hyperplasia, and lower IL-13 in the lung.
Title: Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant.
mechanism by which endogenous B cell activity in vivo is regulated by norepinephrine involves stimulation of the beta2-adrenergic receptor on the B cell alone to increase the level of IgE produced in a p38 MAPK- and soluble CD23-dependent manner
Title: The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner.
A positive internalization signal for IgE transepithelial transport is localized in the cytoplasmic region shared by all CD23 splice forms. This positive signal is negatively regulated by the intracellular CD23b-specific exon.
Title: Intracellular trafficking of CD23: differential regulation in humans and mice by both extracellular and intracellular exons.
Overall, the data provide a direct demonstration for CD23's role in regulating IgE production in vivo and suggest that therapies aimed at stabilizing cell surface CD23 would be beneficial in controlling allergic disease.
Title: In vivo murine CD23 destabilization enhances CD23 shedding and IgE synthesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4)
Spontaneous (1) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492905

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

M34163 (e-PCR)
- UniSTS:159729

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgE binding	IEA Inferred from Electronic Annotation more info
enables IgE binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables low-affinity IgE receptor activity	IEA Inferred from Electronic Annotation more info
enables low-affinity IgE receptor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in B cell antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in Fc receptor-mediated immune complex endocytosis	IEA Inferred from Electronic Annotation more info
involved_in Fc receptor-mediated immune complex endocytosis	ISO Inferred from Sequence Orthology more info
involved_in Fc-epsilon receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric-oxide synthase biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: low affinity immunoglobulin epsilon Fc receptor

Names: FC epsilon RII; fc-epsilon-RII; low-affinity IgE receptor; lymphocyte IgE receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253737.1 → NP_001240666.1 low affinity immunoglobulin epsilon Fc receptor isoform B

See identical proteins and their annotated locations for NP_001240666.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform B) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.

Source sequence(s)

AC087183, M34163

Consensus CDS

CCDS85494.1

UniProtKB/TrEMBL

A0A140LI63

Related

ENSMUSP00000146568.2, ENSMUST00000208492.2

Conserved Domains (2) summary

cd03590
Location:185 → 305

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23720
Location:72 → 169

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001253739.1 → NP_001240668.1 low affinity immunoglobulin epsilon Fc receptor isoform C

See identical proteins and their annotated locations for NP_001240668.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform C) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.

Source sequence(s)

AC087183, M34163

Consensus CDS

CCDS85491.1

UniProtKB/TrEMBL

A0A140LI63

Related

ENSMUSP00000146647.2, ENSMUST00000208145.2

Conserved Domains (2) summary

cd03590
Location:185 → 305

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23720
Location:72 → 169

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001253743.1 → NP_001240672.1 low affinity immunoglobulin epsilon Fc receptor isoform A

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses a different splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform D) is shorter when it is compared to isoform A.

Source sequence(s)

AC087183, M34163

UniProtKB/TrEMBL

A0A140LI63

Related

ENSMUSP00000146689.2, ENSMUST00000207635.2

Conserved Domains (2) summary

cd03590
Location:159 → 279

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23720
Location:46 → 143

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001253745.1 → NP_001240674.1 low affinity immunoglobulin epsilon Fc receptor isoform E

See identical proteins and their annotated locations for NP_001240674.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform E) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform E has also been called Fc epsilon receptor II subtype b variant b delta 5.

Source sequence(s)

AC087183, M34163

Consensus CDS

CCDS85492.1

UniProtKB/TrEMBL

A0A140LI63, Q8VH33

Related

ENSMUSP00000146380.2, ENSMUST00000208603.2

Conserved Domains (2) summary

cd03590
Location:164 → 284

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23720
Location:72 → 148

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001253746.1 → NP_001240675.1 low affinity immunoglobulin epsilon Fc receptor isoform F

See identical proteins and their annotated locations for NP_001240675.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform F) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform F has also been called Fc epsilon receptor II subtype b variant b delta 6.

Source sequence(s)

AC087183, M34163

Consensus CDS

CCDS85493.1

UniProtKB/TrEMBL

A0A140LI63, Q8VH32

Related

ENSMUSP00000146822.2, ENSMUST00000208438.2

Conserved Domains (2) summary

cd03590
Location:164 → 284

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23765
Location:70 → 127

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001253747.1 → NP_001240676.1 low affinity immunoglobulin epsilon Fc receptor isoform G

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform G) is shorter when it is compared to isoform A.

Source sequence(s)

AC087183, M34163

UniProtKB/TrEMBL

A0A140LJ27

Related

ENSMUSP00000147052.2, ENSMUST00000207463.2

Conserved Domains (2) summary

cd03590
Location:146 → 266

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23720
Location:33 → 130

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_013517.4 → NP_038545.1 low affinity immunoglobulin epsilon Fc receptor isoform A

See identical proteins and their annotated locations for NP_038545.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform A).

Source sequence(s)

AC087183, M34163

Consensus CDS

CCDS22071.1

UniProtKB/Swiss-Prot

P20693, Q61556, Q61557

UniProtKB/TrEMBL

A0A140LI63

Related

ENSMUSP00000005678.5, ENSMUST00000005678.6

Conserved Domains (2) summary

cd03590
Location:186 → 306

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23720
Location:73 → 170

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

3730280..3744174 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508697.5 → XP_006508760.1 low affinity immunoglobulin epsilon Fc receptor isoform X1

UniProtKB/TrEMBL

A0A140LI63

Conserved Domains (2) summary

cd03590
Location:190 → 310

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

TIGR04211
Location:77 → 175

SH3_and_anchor; SH3 domain protein