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    P2ry14 purinergic receptor P2Y, G-protein coupled, 14 [ Mus musculus (house mouse) ]

    Gene ID: 140795, updated on 2-Nov-2024

    Summary

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    Official Symbol
    P2ry14provided by MGI
    Official Full Name
    purinergic receptor P2Y, G-protein coupled, 14provided by MGI
    Primary source
    MGI:MGI:2155705
    See related
    Ensembl:ENSMUSG00000036381 AllianceGenome:MGI:2155705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2Y14; Gpr105; A330108O13Rik
    Summary
    Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in plasma membrane. Orthologous to human P2RY14 (purinergic receptor P2Y14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 13.2), large intestine adult (RPKM 3.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See P2ry14 in Genome Data Viewer
    Location:
    3 D; 3 28.96 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (59022044..59060913, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59114623..59153492, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 6 Neighboring gene mediator complex subunit 12-like Neighboring gene STARR-positive B cell enhancer ABC_E6054 Neighboring gene STARR-seq mESC enhancer starr_07762 Neighboring gene STARR-seq mESC enhancer starr_07763 Neighboring gene G protein-coupled receptor 171 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene STARR-seq mESC enhancer starr_07764 Neighboring gene STARR-seq mESC enhancer starr_07765 Neighboring gene predicted gene, 51434 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced urine volume and changed renal sphingolipid metabolism in P2ry14-deficient mice. Baalmann F, et al. Front Cell Dev Biol, 2023. PMID 37250906, Free PMC Article
    2. GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity. Xu J, et al. J Immunol, 2012 Aug 15. PMID 22778393, Free PMC Article
    3. The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity. Kook SH, et al. Cell Death Dis, 2013 Jul 4. PMID 23828566, Free PMC Article
    4. Selective induction of P2Y14 receptor by RANKL promotes osteoclast formation. Lee SA, et al. Mol Cells, 2013 Sep. PMID 24048691, Free PMC Article
    5. Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. Cho J, et al. J Clin Invest, 2014 Jul. PMID 24937426, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils.
      Title: GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils.
    2. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.
      Title: The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.
    3. UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia.
      Title: UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia.
    4. Role of UDP-Sugar Receptor P2Y14 in Murine Osteoblasts.
      Title: Role of UDP-Sugar Receptor P2Y(14) in Murine Osteoblasts.
    5. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.
      Title: Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.
    6. P2Y14 receptor activation decreases interleukin-6 production and glioma GL261 cell proliferation in microglial transwell cultures. These data suggest that P2Y14 receptors may be a key a receptor involved in glioma cell-microglial/macrophage communication in the tumor environment.
      Title: P2Y14 receptor activation decreases interleukin-6 production and glioma GL261 cell proliferation in microglial transwell cultures.
    7. Present study suggests that P2Y14 expression could be used as a phenotypic marker to further dissect placental HSPCs.
      Title: The expression of P2Y14, a purinergic G-protein coupled receptor, defines functionally distinct subpopulations in placenta-derived hematopoietic stem progenitor cells.
    8. Insulin secretion tests revealed a reduced insulin release from P2Y14-deficient islets, highlighting P2Y14 as a new modulator of proper insulin secretion
      Title: The G protein-coupled receptor P2Y14 influences insulin release and smooth muscle function in mice.
    9. the physiological importance of P2Y14 receptors in the vasculature
      Title: Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries.
    10. P2Y14 on stem/progenitor cells of the hematopoietic system inhibits cell senescence by monitoring and responding to the extracellular manifestations of tissue stress
      Title: Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P2Y purinoceptor 14
    Names
    G-protein coupled receptor 105
    UDP-glucose receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008497.2 → NP_001008497.1  P2Y purinoceptor 14 isoform a

      See identical proteins and their annotated locations for NP_001008497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
      Source sequence(s)
      AC115919, AK164982, BC058558
      Consensus CDS
      CCDS17371.1
      UniProtKB/Swiss-Prot
      Q9ESG6
      UniProtKB/TrEMBL
      Q544F4
      Related
      ENSMUSP00000066669.7, ENSMUST00000065220.13
      Conserved Domains (1) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001287119.1 → NP_001274048.1  P2Y purinoceptor 14 isoform a

      See identical proteins and their annotated locations for NP_001274048.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
      Source sequence(s)
      AC115919
      Consensus CDS
      CCDS17371.1
      UniProtKB/Swiss-Prot
      Q9ESG6
      UniProtKB/TrEMBL
      Q544F4
      Related
      ENSMUSP00000142601.2, ENSMUST00000196081.5
      Conserved Domains (1) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_001287120.1 → NP_001274049.1  P2Y purinoceptor 14 isoform a

      See identical proteins and their annotated locations for NP_001274049.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
      Source sequence(s)
      AK164982, BY177387
      Consensus CDS
      CCDS17371.1
      UniProtKB/Swiss-Prot
      Q9ESG6
      UniProtKB/TrEMBL
      Q544F4
      Conserved Domains (1) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. NM_001287121.1 → NP_001274050.1  P2Y purinoceptor 14 isoform a

      See identical proteins and their annotated locations for NP_001274050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
      Source sequence(s)
      AK039791, AK164982, CF169635
      Consensus CDS
      CCDS17371.1
      UniProtKB/Swiss-Prot
      Q9ESG6
      UniProtKB/TrEMBL
      Q544F4
      Conserved Domains (1) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    5. NM_001287122.1 → NP_001274051.1  P2Y purinoceptor 14 isoform a

      See identical proteins and their annotated locations for NP_001274051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
      Source sequence(s)
      AK164982, CK622172
      Consensus CDS
      CCDS17371.1
      UniProtKB/Swiss-Prot
      Q9ESG6
      UniProtKB/TrEMBL
      Q544F4
      Conserved Domains (1) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    6. NM_001287123.1 → NP_001274052.1  P2Y purinoceptor 14 isoform a

      See identical proteins and their annotated locations for NP_001274052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
      Source sequence(s)
      AK039791, AK164982
      Consensus CDS
      CCDS17371.1
      UniProtKB/Swiss-Prot
      Q9ESG6
      UniProtKB/TrEMBL
      Q544F4
      Related
      ENSMUSP00000143070.2, ENSMUST00000197220.2
      Conserved Domains (1) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    7. NM_001287124.1 → NP_001274053.1  P2Y purinoceptor 14 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 3' terminal exon which results in a distinct 5' UTR and causes translation initiation at an upstream start codon compared to variant 1. It encodes isoform b which is longer and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC115919
      Consensus CDS
      CCDS79913.1
      UniProtKB/TrEMBL
      A0A0G2JEW9
      Related
      ENSMUSP00000142934.2, ENSMUST00000197841.2
      Conserved Domains (1) summary
      pfam00001
      Location:49 → 304
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    8. NM_133200.4 → NP_573463.1  P2Y purinoceptor 14 isoform a

      See identical proteins and their annotated locations for NP_573463.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (a). Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AC115919, AK164982
      Consensus CDS
      CCDS17371.1
      UniProtKB/Swiss-Prot
      Q9ESG6
      UniProtKB/TrEMBL
      Q544F4
      Related
      ENSMUSP00000088642.5, ENSMUST00000091112.6
      Conserved Domains (1) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      59022044..59060913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESG6.1 GenPept UniProtKB/Swiss-Prot:Q9ESG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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