Ackr1 atypical chemokine receptor 1 (Duffy blood group) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ackr1provided by MGI
Official Full Name: atypical chemokine receptor 1 (Duffy blood group)provided by MGI
Primary source: MGI:MGI:1097689
See related: Ensembl:ENSMUSG00000037872 AllianceGenome:MGI:1097689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FY; Dfy; GPD; Darc; CCBP1; CD234; ESTM35
Summary: Predicted to enable C-C chemokine binding activity. Acts upstream of or within inflammatory response and regulation of chemokine production. Predicted to be located in early endosome; membrane; and recycling endosome. Is expressed in several structures, including genitourinary system; hemolymphoid system; lung; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Plasmodium vivax malaria and malaria. Orthologous to human ACKR1 (atypical chemokine receptor 1 (Duffy blood group)). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in cerebellum adult (RPKM 65.4), liver E14.5 (RPKM 38.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 80.33 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (173159457..173161079, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (173331886..173333503, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A subset of macrophages and monocytes in the mouse bone marrow express atypical chemokine receptor 1.
Title: A subset of macrophages and monocytes in the mouse bone marrow express atypical chemokine receptor 1.
ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.
Title: ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.
Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 are involved in neutrophil emigration.
Title: Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis.
DARC regulates metabolic function and adipose tissue inflammation.
Title: Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding.
Our findings in mice suggest that DARC alters the severity and resolution of AHR. These findings are complimented by our human analyses in which select DARC SNPs are associated with worse asthma control and symptoms.
Title: The Duffy antigen receptor for chemokines regulates asthma pathophysiology.
DARC was exquisitely restricted to post-capillary and small collecting venules and completely absent from arteries, arterioles, capillaries, veins, and most lymphatics in every tissue analyzed. Intravital microscopy showed that adhesive leukocyte-endothelial interactions were restricted to DARC(+) venules. DARC was detectable over the entire circumference of V-ECs, but was more concentrated at cell-cell junctions.
Title: Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues.
DARC regulates recruitment of osteoclast precursors at the inflammation site
Title: Potential Role of DARC-Chemokine Interaction in the Recruitment of Osteoclast Precursors in Response to Bacterial Lipopolysaccharide Challenge.
Nucleated erythroid cells had high expression of ACKR1, which facilitated their direct contact with hematopoietic stem cells. The absence of erythroid ACKR1 altered mouse hematopoiesis including stem and progenitor cells, which ultimately gave rise to phenotypically distinct neutrophils that readily left the circulation, causing neutropenia.
Title: Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.
The DARC/CD234 is expressed on macrophages and stabilizes CD82 on long-term repopulating hematopoietic stem cells, promoting their quiescence.
Title: CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages.
Ackr1 deficiency appears to be protective in the ApoE knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine expression as well as T-cell subset frequency and inflammatory macrophage content.
Title: Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

General gene information

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Markers

Darc (e-PCR), detects polymorphism
- UniSTS:536447

Darc (e-PCR), detects polymorphism
- UniSTS:256664

AF016697 (e-PCR)
- UniSTS:158891

AA162249 (e-PCR), detects polymorphism
- UniSTS:143021

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables chemokine binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: atypical chemokine receptor 1

Names: Duffy antigen receptor for chemokines; Duffy blood group, chemokine receptor; duffy antigen/chemokine receptor; glycoprotein D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010045.3 → NP_034175.2 atypical chemokine receptor 1

See identical proteins and their annotated locations for NP_034175.2

Status: VALIDATED

Source sequence(s)

AC084073

Consensus CDS

CCDS35789.1

UniProtKB/TrEMBL

A0A0R4J0J4, Q7TSL2

Related

ENSMUSP00000045134.5, ENSMUST00000038227.6

Conserved Domains (1) summary

cd15010
Location:58 → 314

7tmA_ACKR1_DARC; Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors