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    CD200R1 CD200 receptor 1 [ Homo sapiens (human) ]

    Gene ID: 131450, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CD200R1provided by HGNC
    Official Full Name
    CD200 receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:24235
    See related
    Ensembl:ENSG00000163606 MIM:607546; AllianceGenome:HGNC:24235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OX2R; MOX2R; CD200R; HCRTR2
    Summary
    This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 4.6), placenta (RPKM 2.9) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD200R1 in Genome Data Viewer
    Location:
    3q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (112921205..112975103, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (115642153..115696046, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112640052..112693950, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CD200R1L antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112543386-112543886 Neighboring gene CD200 receptor 1 like Neighboring gene ReSE screen-validated silencer GRCh37_chr3:112563646-112563805 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112590118-112590618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112603434-112604024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112604025-112604615 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:112612841-112614040 Neighboring gene CD200R1 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112709373-112710000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14605 Neighboring gene GTP binding protein 8 Neighboring gene NEPRO antisense RNA 1 Neighboring gene nucleolus and neural progenitor protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model. Ahmed M, et al. Front Immunol, 2024. PMID 38745652, Free PMC Article
    2. The Receptor for the CD200 Tolerance-Signaling Molecule Associated with Successful Pregnancy is Expressed by Early-Stage Breast Cancer Cells in 80% of Patients and by Term Placental Trophoblasts. Clark DA, et al. Am J Reprod Immunol, 2015 Nov. PMID 26011475
    3. Reduced Dendritic Cells Expressing CD200R1 in Children with Inflammatory Bowel Disease: Correlation with Th17 and Regulatory T Cells. Elshal MF, et al. Int J Mol Sci, 2015 Dec 4. PMID 26690123, Free PMC Article
    4. CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma. Sun H, et al. Immunol Lett, 2016 Oct. PMID 27562325
    5. Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis. Fraser SD, et al. Sci Rep, 2016 Dec 8. PMID 27929051, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease.
      Title: The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease.
    2. Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model.
      Title: Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model.
    3. CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway.
      Title: CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway.
    4. Inflammatory dendritic cells restrain CD11b[+]CD4[+] CTLs via CD200R in human NSCLC.
      Title: Inflammatory dendritic cells restrain CD11b(+)CD4(+) CTLs via CD200R in human NSCLC.
    5. Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy.
      Title: Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy.
    6. The Role of CD200-CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation.
      Title: The Role of CD200-CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation.
    7. Tumor-Infiltrating T Cells Concurrently Overexpress CD200R with Immune Checkpoints PD-1, CTLA-4, and TIM-3 in Non-Small-Cell Lung Cancer.
      Title: Tumor-Infiltrating T Cells Concurrently Overexpress CD200R with Immune Checkpoints PD-1, CTLA-4, and TIM-3 in Non-Small-Cell Lung Cancer.
    8. Up-regulation of CD200/CD200R1 Immunomodulatory Axis of Allogenic Peripheral Blood Mononuclear Cells in a Co-culture with Adipose-derived Mesenchymal Stem Cells.
      Title: Up-regulation of CD200/CD200R1 Immunomodulatory Axis of Allogenic Peripheral Blood Mononuclear Cells in a Co-culture with Adipose-derived Mesenchymal Stem Cells.
    9. Identification of a novel conserved signaling motif in CD200 receptor required for its inhibitory function.
      Title: Identification of a novel conserved signaling motif in CD200 receptor required for its inhibitory function.
    10. Identification of the CD200R1 promoter and the association of its polymorphisms with the risk of Parkinson's disease.
      Title: Identification of the CD200R1 promoter and the association of its polymorphisms with the risk of Parkinson's disease.
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glycosylated region protein binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables immunoglobulin receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of macrophage migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell surface glycoprotein CD200 receptor 1
    Names
    CD200 cell surface glycoprotein receptor
    MOX2 receptor
    cell surface glycoprotein OX2 receptor 1
    cell surface glycoprotein receptor CD200

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138806.4 → NP_620161.1  cell surface glycoprotein CD200 receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_620161.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript variant and encodes the longest isoform (a).
      Source sequence(s)
      AC074044, AF495380, AK126349, AY358910
      Consensus CDS
      CCDS2969.1
      UniProtKB/Swiss-Prot
      B3KWZ9, E9PCM9, Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45, Q8TD46, Q8TD52
      UniProtKB/TrEMBL
      B7ZKV2
      Related
      ENSP00000311035.3, ENST00000308611.8
      Conserved Domains (1) summary
      cl11960
      Location:188 → 257
      Ig; Immunoglobulin domain

    2. NM_138939.3 → NP_620385.1  cell surface glycoprotein CD200 receptor 1 isoform b precursor

      See identical proteins and their annotated locations for NP_620385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the coding region, compared to variant 1. This results in a frameshift and early stop codon, as well as loss of an immunoglobulin and transmembrane domain in the protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC074044, AF497549, AK126349
      Consensus CDS
      CCDS46889.1
      UniProtKB/Swiss-Prot
      Q8TD46
      Related
      ENSP00000405733.2, ENST00000440122.6

    3. NM_138940.3 → NP_620386.1  cell surface glycoprotein CD200 receptor 1 isoform c precursor

      See identical proteins and their annotated locations for NP_620386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1. This results in a frameshift and early stop codon, as well as loss of an immunoglobulin and transmembrane domain in the protein (isoform c), compared to isoform a.
      Source sequence(s)
      AC074044, AF497550, AK126349
      Consensus CDS
      CCDS54623.1
      UniProtKB/Swiss-Prot
      Q8TD46
      Related
      ENSP00000418801.1, ENST00000490004.1

    4. NM_170780.3 → NP_740750.1  cell surface glycoprotein CD200 receptor 1 isoform d precursor

      See identical proteins and their annotated locations for NP_740750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) utilizes an alternate splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform d), compared to isoform a.
      Source sequence(s)
      AC074044, AF497548, AK126349
      Consensus CDS
      CCDS2970.1
      UniProtKB/TrEMBL
      B7ZKV2
      Related
      ENSP00000418928.1, ENST00000471858.5
      Conserved Domains (2) summary
      cd00096
      Location:44 → 49
      Ig; Ig strand A [structural motif]
      cl11960
      Location:44 → 150
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      112921205..112975103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      115642153..115696046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TD46.4 GenPept UniProtKB/Swiss-Prot:Q8TD46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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