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    Cd69 CD69 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12515, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cd69provided by MGI
    Official Full Name
    CD69 antigenprovided by MGI
    Primary source
    MGI:MGI:88343
    See related
    Ensembl:ENSMUSG00000030156 AllianceGenome:MGI:88343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIM; VEA; 5830438K24Rik
    Summary
    Predicted to enable calcium ion binding activity and identical protein binding activity. Involved in cellular response to xenobiotic stimulus. Located in external side of plasma membrane. Orthologous to human CD69 (CD69 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 3.8), spleen adult (RPKM 1.1) and 6 other tissues See more
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    Genomic context

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    See Cd69 in Genome Data Viewer
    Location:
    6 F3; 6 63.21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129244287..129252332, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129267324..129275375, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4870 Neighboring gene predicted gene, 38906 Neighboring gene STARR-positive B cell enhancer ABC_E6494 Neighboring gene STARR-positive B cell enhancer ABC_E9102 Neighboring gene RIKEN cDNA 2310001H17 gene Neighboring gene STARR-positive B cell enhancer ABC_E690 Neighboring gene STARR-positive B cell enhancer ABC_E6495 Neighboring gene STARR-positive B cell enhancer ABC_E4871 Neighboring gene STARR-positive B cell enhancer ABC_E8140 Neighboring gene STARR-positive B cell enhancer ABC_E9019 Neighboring gene STARR-positive B cell enhancer ABC_E6496 Neighboring gene STARR-positive B cell enhancer ABC_E6497 Neighboring gene STARR-positive B cell enhancer ABC_E1329 Neighboring gene STARR-positive B cell enhancer ABC_E11735 Neighboring gene STARR-positive B cell enhancer ABC_E1330 Neighboring gene STARR-positive B cell enhancer ABC_E3684 Neighboring gene STARR-positive B cell enhancer ABC_E9103 Neighboring gene C-type lectin domain family 2, member m Neighboring gene STARR-seq mESC enhancer starr_17478 Neighboring gene STARR-seq mESC enhancer starr_17479 Neighboring gene C-type lectin domain family 12, member a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc. Kai T, et al. PLoS One, 2014. PMID 24804991, Free PMC Article
    2. CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis. Cibrian D, et al. Nat Immunol, 2016 Aug. PMID 27376471, Free PMC Article
    3. CD69 Deficiency Enhances the Host Response to Vaccinia Virus Infection through Altered NK Cell Homeostasis. Notario L, et al. J Virol, 2016 Jul 15. PMID 27147744, Free PMC Article
    4. Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin. Yamauchi K, et al. Respir Res, 2011 Oct 5. PMID 21970554, Free PMC Article
    5. Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice. Tsuyusaki J, et al. J Recept Signal Transduct Res, 2011 Dec. PMID 22070386

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD69 Is Indispensable for Development of Functional Local Immune Memory in Murine Contact Hypersensitivity.
      Title: CD69 Is Indispensable for Development of Functional Local Immune Memory in Murine Contact Hypersensitivity.
    2. CD69 expression on regulatory T cells protects from immune damage after myocardial infarction.
      Title: CD69 expression on regulatory T cells protects from immune damage after myocardial infarction.
    3. The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
      Title: The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
    4. CD69 deficiency promotes a prothrombotic phenotype characterized by increased von Willebrand factor and worse brain damage after ischemic stroke. The results suggest that CD69 acts as a downregulator of endothelial activation.
      Title: CD69 Plays a Beneficial Role in Ischemic Stroke by Dampening Endothelial Activation.
    5. CD69 is important to the suppressive function of Tregs by promoting IL-10 production.
      Title: CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.
    6. Oxidized low-density lipoprotein binding to CD69 confers a regulatory phenotype to mouse T cells, dampening Th17 responses and ameliorating atherosclerosis.
      Title: Oxidized Low-Density Lipoprotein Receptor in Lymphocytes Prevents Atherosclerosis and Predicts Subclinical Disease.
    7. This study reveals the importance of CD69 to prolong the thymic residency time of developing immature precursors for proper differentiation of a T cell subset, NKT2 cells.
      Title: CD69 prevents PLZF(hi) innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation.
    8. These studies showed that VCAM1 contributes not only to the initiation of myelination but also to its regulation through controlling the abundance of CD69, demonstrating that an intercellular molecule whose primary role is in the immune system can also play an unexpected role in the CNS.
      Title: VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.
    9. AIM plays an orchestrating role in the resolution process of inflammation by altering the profile of pulmonary lipid mediators
      Title: Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury.
    10. Data show that a subset of inflammation-induced CD69(+) Kupffer cells which can feedback inhibit CD4 T cell response via cell surface TGF-beta1 at the late stage of immune response against infection.
      Title: Inflammation-induced CD69(+) Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular sequestering activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of T cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T-helper 17 cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    early activation antigen CD69
    Names
    Very Early Activation Antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033122.4 → NP_001028294.1  early activation antigen CD69

      See identical proteins and their annotated locations for NP_001028294.1

      Status: VALIDATED

      Source sequence(s)
      AK151076, BE691115, BY193860
      Consensus CDS
      CCDS20582.1
      UniProtKB/Swiss-Prot
      P37217
      UniProtKB/TrEMBL
      Q3U6A8
      Related
      ENSMUSP00000032259.4, ENSMUST00000032259.6
      Conserved Domains (2) summary
      cd03593
      Location:85 → 196
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      PHA03097
      Location:43 → 197
      PHA03097; C-type lectin-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129244287..129252332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505463.3 → XP_006505526.1  early activation antigen CD69 isoform X1

      Conserved Domains (1) summary
      cd03593
      Location:72 → 183
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37217.1 GenPept UniProtKB/Swiss-Prot:P37217

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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