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    Cct8 chaperonin containing TCP1 subunit 8 [ Mus musculus (house mouse) ]

    Gene ID: 12469, updated on 18-Sep-2024

    Summary

    Official Symbol
    Cct8provided by MGI
    Official Full Name
    chaperonin containing TCP1 subunit 8provided by MGI
    Primary source
    MGI:MGI:107183
    See related
    Ensembl:ENSMUSG00000025613 AllianceGenome:MGI:107183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cctq; Tcpq
    Summary
    Predicted to enable protein folding chaperone and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida; pore complex assembly; and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human CCT8 (chaperonin containing TCP1 subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 95.8), placenta adult (RPKM 88.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cct8 in Genome Data Viewer
    Location:
    16 C3.3; 16 49.57 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87280213..87292757, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87483325..87495869, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene predicted gene, 25896 Neighboring gene STARR-positive B cell enhancer ABC_E1186 Neighboring gene STARR-positive B cell enhancer ABC_E11624 Neighboring gene RWD domain containing 2B Neighboring gene STARR-positive B cell enhancer ABC_E10922 Neighboring gene ubiquitin specific peptidase 16 Neighboring gene RIKEN cDNA B130034C11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5556 Neighboring gene predicted gene, 24891

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chaperonin-containing T-complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of zona pellucida receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-complex protein 1 subunit theta
    Names
    CCT-theta
    TCP-1-theta
    chaperonin containing Tcp1, subunit 8 (theta)
    chaperonin subunit 8 (theta)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009840.3NP_033970.3  T-complex protein 1 subunit theta

      See identical proteins and their annotated locations for NP_033970.3

      Status: VALIDATED

      Source sequence(s)
      AK075711, AK075880, AK147038, AV335786
      Consensus CDS
      CCDS37384.1
      UniProtKB/Swiss-Prot
      P42932
      UniProtKB/TrEMBL
      Q3UKQ2, Q3UL22, Q8BVY8
      Related
      ENSMUSP00000026704.8, ENSMUST00000026704.14
      Conserved Domains (2) summary
      TIGR02346
      Location:10539
      chap_CCT_theta; T-complex protein 1, theta subunit
      pfam00118
      Location:39528
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      87280213..87292757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)