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    Calu calumenin [ Mus musculus (house mouse) ]

    Gene ID: 12321, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Caluprovided by MGI
    Official Full Name
    calumeninprovided by MGI
    Primary source
    MGI:MGI:1097158
    See related
    Ensembl:ENSMUSG00000029767 AllianceGenome:MGI:1097158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9530075H20Rik
    Summary
    Enables calcium ion binding activity. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and immune system. Orthologous to human CALU (calumenin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 120.1), limb E14.5 (RPKM 116.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Calu in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29348105..29376674)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29348106..29376675)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene golgi associated RAB2 interactor 1A Neighboring gene STARR-seq mESC enhancer starr_15437 Neighboring gene golgi associated RAB2 interactor 1B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29297688-29297797 Neighboring gene opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Neighboring gene nuclear encoded tRNA proline 6 (anticodon AGG) Neighboring gene blue cone (S) opsin upstream regulatory region Neighboring gene coiled-coil domain containing 136

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of isoforms and genomic organization of mouse calumenin. Jung DH, et al. Gene, 2004 Mar 3. PMID 14980715
    2. Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum. Sahoo SK, et al. J Biol Chem, 2009 Nov 6. PMID 19740751, Free PMC Article
    3. Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. Wang Q, et al. Oncogene, 2015 Feb 19. PMID 24632605
    4. Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. Yabe D, et al. Genomics, 1998 Apr 15. PMID 9598325
    5. Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain. Vasiljevic M, et al. Neuroscience, 2012 Jan 27. PMID 22178608, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extracellular calumenin regulates fibulin-1 to have crucial roles in ERK1/2 signaling and cell migration.
      Title: Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis.
    2. This study points to a possible important role of calumenin in migration and differentiation of neurons
      Title: Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain.
    3. Regions of 132-222 amino acids of calumenin and 853-892 amino acids of SERCA2 are the major binding partners.
      Title: Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calumenin
    Names
    crocalbin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285412.1 → NP_001272341.1  calumenin isoform 3

      See identical proteins and their annotated locations for NP_001272341.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate splice site in the 5' coding region, resulting in a distinct 5' UTR and initiation of translation from a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC044807
      UniProtKB/TrEMBL
      G3V004
      Related
      ENSMUSP00000134708.2, ENSMUST00000173216.8
      Conserved Domains (2) summary
      cd15899
      Location:4 → 33
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:1 → 148
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

    2. NM_007594.4 → NP_031620.1  calumenin isoform 1 precursor

      See identical proteins and their annotated locations for NP_031620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK135295, AK148178, AK163674, CJ084197
      Consensus CDS
      CCDS19957.1
      UniProtKB/Swiss-Prot
      O35887
      UniProtKB/TrEMBL
      Q3TUF3, Q3UG11
      Related
      ENSMUSP00000031779.11, ENSMUST00000031779.17
      Conserved Domains (1) summary
      cd16228
      Location:37 → 299
      EFh_CREC_Calumenin; EF-hand, calcium binding motif, found in calumenin

    3. NM_184053.3 → NP_908942.1  calumenin isoform 2 precursor

      See identical proteins and their annotated locations for NP_908942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and contains a different alternate exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which contains a different internal segment, compared to isoform 1.
      Source sequence(s)
      AK135295, AK147756, AK148178, AK163674, CJ084197
      Consensus CDS
      CCDS19958.1
      UniProtKB/TrEMBL
      Q3TL33, Q6XLQ8
      Related
      ENSMUSP00000087967.8, ENSMUST00000090481.14
      Conserved Domains (1) summary
      cd16228
      Location:37 → 299
      EFh_CREC_Calumenin; EF-hand, calcium binding motif, found in calumenin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29348105..29376674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165784.1 → XP_036021677.1  calumenin isoform X1

      Conserved Domains (2) summary
      cd15899
      Location:1 → 27
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:1 → 225
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35887.1 GenPept UniProtKB/Swiss-Prot:O35887

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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