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Park7 Parkinsonism associated deglycase [ Rattus norvegicus (Norway rat) ]

Gene ID: 117287, updated on 28-Oct-2024

Summary

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Official Symbol: Park7provided by RGD
Official Full Name: Parkinsonism associated deglycaseprovided by RGD
Primary source: RGD:621808
See related: EnsemblRapid:ENSRNOG00000018289 AllianceGenome:RGD:621808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dj1; CAP1; DJ-1; SP22
Summary: Predicted to enable several functions, including enzyme activator activity; enzyme binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of NMDA glutamate receptor activity; negative regulation of vascular associated smooth muscle cell proliferation; and positive regulation of fertilization. Located in several cellular components, including endoplasmic reticulum; mitochondrion; and sperm head. Used to study Parkinson's disease and Parkinsonism. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Muscle (RPKM 779.6), Kidney (RPKM 488.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Park7 in Genome Data Viewer

Location:: 5q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (166636551..166659825, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (161353718..161376993, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (167982438..168004724, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DJ-1 preserves ischemic postconditioning-induced cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1 subcellular translocation.
Title: DJ-1 preserves ischemic postconditioning-induced cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1 subcellular translocation.
Oxidized DJ-1 activates the p-IKK/NF-kappaB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury.
Title: Oxidized DJ-1 activates the p-IKK/NF-κB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury.
Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy.
Title: Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy.
A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism.
Title: A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism.
In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress.
Title: In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress.
DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury.
Title: DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury.
DJ-1 Protein Inhibits Apoptosis in Cerebral Ischemia by Regulating the Notch1 and Nuclear Factor Erythroid2-Related Factor 2 Signaling Pathways.
Title: DJ-1 Protein Inhibits Apoptosis in Cerebral Ischemia by Regulating the Notch1 and Nuclear Factor Erythroid2-Related Factor 2 Signaling Pathways.
Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1alpha-dependent expression of collagen I (alpha2) during renal fibrosis.
Title: Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis.
Parkinson's disease protein 7 protected against oxidative stress of myocardial infarction direct through p47phox and nicotinamide adenine dinucleotide phosphate oxidase 4.
Title: Parkinson's disease protein 7 protected against oxidative stress of myocardial infarction direct through p47phox and nicotinamide adenine dinucleotide phosphate oxidase 4.
Characterization of striatum-mediated behavior and neurochemistry in the DJ-1 knock-out rat model of Parkinson's disease.
Title: Characterization of striatum-mediated behavior and neurochemistry in the DJ-1 knock-out rat model of Parkinson's disease.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables L-dopa decarboxylase activator activity	IEA Inferred from Electronic Annotation more info
enables L-dopa decarboxylase activator activity	ISO Inferred from Sequence Orthology more info
enables L-dopa decarboxylase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cupric ion binding	IEA Inferred from Electronic Annotation more info
enables cupric ion binding	ISO Inferred from Sequence Orthology more info
enables cupric ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cuprous ion binding	IEA Inferred from Electronic Annotation more info
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables cuprous ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytokine binding	IEA Inferred from Electronic Annotation more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables cytokine binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glyoxalase (glycolic acid-forming) activity	IEA Inferred from Electronic Annotation more info
enables glyoxalase (glycolic acid-forming) activity	ISO Inferred from Sequence Orthology more info
enables glyoxalase (glycolic acid-forming) activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mercury ion binding	IEA Inferred from Electronic Annotation more info
enables mercury ion binding	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear androgen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on peroxide as acceptor	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on peroxide as acceptor	ISO Inferred from Sequence Orthology more info
enables oxygen sensor activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables peptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peroxiredoxin activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein deglycase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein deglycase activity	ISO Inferred from Sequence Orthology more info
enables protein deglycase activity	ISO Inferred from Sequence Orthology more info
NOT enables protein deglycase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein deglycase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor activator activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activator activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables small protein activating enzyme binding	IEA Inferred from Electronic Annotation more info
enables small protein activating enzyme binding	ISO Inferred from Sequence Orthology more info
enables small protein activating enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables superoxide dismutase copper chaperone activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase copper chaperone activity	ISO Inferred from Sequence Orthology more info
enables superoxide dismutase copper chaperone activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables tyrosine 3-monooxygenase activator activity	IEA Inferred from Electronic Annotation more info
enables tyrosine 3-monooxygenase activator activity	ISO Inferred from Sequence Orthology more info
enables tyrosine 3-monooxygenase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like protein conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein conjugating enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification of aldehyde	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification of aldehyde	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular detoxification of methylglyoxal	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification of methylglyoxal	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glyoxal	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glyoxal	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glyoxal	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in detection of oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in detoxification of copper ion	IEA Inferred from Electronic Annotation more info
involved_in detoxification of copper ion	ISO Inferred from Sequence Orthology more info
involved_in detoxification of copper ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in detoxification of hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in detoxification of hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in detoxification of hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in detoxification of mercury ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine uptake involved in synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in fertilization	TAS Traceable Author Statement more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycolate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycolate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycolate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glyoxal catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glyoxal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in guanine deglycation	ISO Inferred from Sequence Orthology more info
involved_in guanine deglycation	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine deglycation, glyoxal removal	IEA Inferred from Electronic Annotation more info
involved_in guanine deglycation, glyoxal removal	ISO Inferred from Sequence Orthology more info
involved_in guanine deglycation, glyoxal removal	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine deglycation, methylglyoxal removal	IEA Inferred from Electronic Annotation more info
involved_in guanine deglycation, methylglyoxal removal	ISO Inferred from Sequence Orthology more info
involved_in guanine deglycation, methylglyoxal removal	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lactate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within membrane depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in methylglyoxal catabolic process to lactate	IEA Inferred from Electronic Annotation more info
involved_in methylglyoxal catabolic process to lactate	ISO Inferred from Sequence Orthology more info
involved_in methylglyoxal catabolic process to lactate	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in methylglyoxal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in methylglyoxal metabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in methylglyoxal metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TRAIL-activated apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TRAIL-activated apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TRAIL-activated apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of death-inducing signaling complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of death-inducing signaling complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein K48-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein acetylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of L-dopa biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of L-dopa biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of L-dopa biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NAD(P)H oxidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NAD(P)H oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response to antigenic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dopamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oxidative phosphorylation uncoupler activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxidative phosphorylation uncoupler activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein repair	IEA Inferred from Electronic Annotation more info
involved_in protein repair	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
NOT involved_in regulation of TRAIL production	ISO Inferred from Sequence Orthology more info
involved_in regulation of androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in single fertilization	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sperm head	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Parkinson disease protein 7 homolog

Names: Parkinson disease (autosomal recessive, early onset) 7; contraception-associated protein 1; fertility protein SP22; maillard deglycase; parkinson disease protein 7 homolog; parkinson protein 7; protein DJ-1; protein deglycase DJ-1; protein/nucleic acid deglycase DJ-1

NP_001264178.1

EC 3.5.1.124

NP_001264179.1

EC 3.5.1.124

NP_001264180.1

EC 3.5.1.124

NP_001264181.1

EC 3.5.1.124

NP_001264182.1

EC 3.5.1.124

NP_476484.1

EC 3.5.1.124

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277249.1 → NP_001264178.1 Parkinson disease protein 7 homolog isoform 1

See identical proteins and their annotated locations for NP_001264178.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

BC091128, JAXUCZ010000005

UniProtKB/TrEMBL

Q5BKC3

Related

ENSRNOP00000074942.1, ENSRNOT00000091206.3

Conserved Domains (1) summary

cd03135
Location:6 → 141

GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
NM_001277250.1 → NP_001264179.1 Parkinson disease protein 7 homolog isoform 2

See identical proteins and their annotated locations for NP_001264179.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.

Source sequence(s)

FM055257, JAXUCZ010000005

UniProtKB/Swiss-Prot

O88767

UniProtKB/TrEMBL

A0A8I6GCY6, A6IUE4

Conserved Domains (1) summary

TIGR01383
Location:5 → 184

not_thiJ; DJ-1 family protein
NM_001277251.1 → NP_001264180.1 Parkinson disease protein 7 homolog isoform 2

See identical proteins and their annotated locations for NP_001264180.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.

Source sequence(s)

FM055257, JAXUCZ010000005

UniProtKB/Swiss-Prot

O88767

UniProtKB/TrEMBL

A0A8I6GCY6, A6IUE4

Conserved Domains (1) summary

TIGR01383
Location:5 → 184

not_thiJ; DJ-1 family protein
NM_001277252.1 → NP_001264181.1 Parkinson disease protein 7 homolog isoform 2

See identical proteins and their annotated locations for NP_001264181.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.

Source sequence(s)

FM061417, JAXUCZ010000005

UniProtKB/Swiss-Prot

O88767

UniProtKB/TrEMBL

A0A8I6GCY6, A6IUE4

Conserved Domains (1) summary

TIGR01383
Location:5 → 184

not_thiJ; DJ-1 family protein
NM_001277253.1 → NP_001264182.1 Parkinson disease protein 7 homolog isoform 2

See identical proteins and their annotated locations for NP_001264182.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.

Source sequence(s)

FM069664, JAXUCZ010000005

UniProtKB/Swiss-Prot

O88767

UniProtKB/TrEMBL

A0A8I6GCY6, A6IUE4

Conserved Domains (1) summary

TIGR01383
Location:5 → 184

not_thiJ; DJ-1 family protein
NM_057143.2 → NP_476484.1 Parkinson disease protein 7 homolog isoform 2

See identical proteins and their annotated locations for NP_476484.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.

Source sequence(s)

FM055257, JAXUCZ010000005

UniProtKB/Swiss-Prot

O88767

UniProtKB/TrEMBL

A0A8I6GCY6, A6IUE4

Related

ENSRNOP00000072068.1, ENSRNOT00000087402.3

Conserved Domains (1) summary

TIGR01383
Location:5 → 184

not_thiJ; DJ-1 family protein