Mat1a methionine adenosyltransferase 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mat1aprovided by MGI
Official Full Name: methionine adenosyltransferase 1Aprovided by MGI
Primary source: MGI:MGI:88017
See related: Ensembl:ENSMUSG00000037798 AllianceGenome:MGI:88017
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ams; MAT; SAMS; MATA1; SAMS1; AdoMet
Summary: This gene encodes a member of the AdoMet synthase family. Methionine adenosyltransferase is a product of this gene (the alpha form) and the beta form and catalyzes the formation of S-adenosylmethionine from methionine and ATP.[provided by RefSeq, Jan 2013]
Expression: Restricted expression toward liver adult (RPKM 598.5) See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 22.36 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (40826969..40846385)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (41105012..41124428)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deregulated 14-3-3zeta and methionine adenosyltransferase alpha1 interplay promotes liver cancer tumorigenesis in mice and humans.
Title: Deregulated 14-3-3ζ and methionine adenosyltransferase α1 interplay promotes liver cancer tumorigenesis in mice and humans.
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis.
Title: Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis.
a critical role of MATalpha1 in regulating mitochondrial function by suppressing CYP2E1 expression at multiple levels.
Title: Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression.
The reproduction of these changes in MAT1A-KO mice, prone to develop hepatitis and HCC, demonstrates the pathogenetic role of MAT1A gene under-regulation associated with up-regulation of the MAT2A gene (MAT1A:MAT2A switch), encoding the SAM synthesizing enzymes, methyladenosyltransferase I/III (MATI/III) and methyladenosyltransferase II (MATII), respectively. This leads to a rise of MATII, inhibited by the reaction produc
Title: Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch.
Title: A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis
Title: Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡).
MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD development in MAT1A-KO mice.
Title: Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice.
DUSP1 mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.
Title: S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes.
CD133(+)CD45(-) oval cells isolated from premalignant 16-month-old Mat1a(-/-) mice demonstrated significant resistance to transforming growth factor-beta-induced apoptosis compared to CD133(-) cells.
Title: CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis.
By 1 month of age, genomic instability increases in livers of Mat1a knockout mice, possibly due to reduced APEX1 levels
Title: S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MAT1A (e-PCR)
- UniSTS:511885

46.MMHAP11FLH4.seq (e-PCR)
- UniSTS:124610

AI046368 (e-PCR)
- UniSTS:163550

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methionine adenosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methionine adenosyltransferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in S-adenosylmethionine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in S-adenosylmethionine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in methionine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in methionine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of methionine adenosyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of methionine adenosyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthase

Names: adoMet synthetase 1; methionine adenosyltransferase I, alpha

NP_598414.1

EC 2.5.1.6

XP_006518513.1

EC 2.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.