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    Gps1 G protein pathway suppressor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117039, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Gps1provided by RGD
    Official Full Name
    G protein pathway suppressor 1provided by RGD
    Primary source
    RGD:621532
    See related
    EnsemblRapid:ENSRNOG00000046698 AllianceGenome:RGD:621532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MFH
    Summary
    Predicted to be involved in protein deneddylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 389.1), Testes (RPKM 304.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gps1 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106548646..106553729)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106050323..106055407)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109966875..109971912)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene carbonyl reductase 2 like 1 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1-like Neighboring gene uncharacterized LOC120095225

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. JAB1 is Involved in Neuropathic Pain by Regulating JNK and NF-κB Activation After Chronic Constriction Injury. Chen Y, et al. Neurochem Res, 2016 May. PMID 26700435
    2. A fusca gene homologue in mammalian tissues: Developmental regulation in the rat testes. Nitz B, et al. Mol Cell Endocrinol, 1998 Sep 25. PMID 9863633
    3. Dynamic changes of Jab1 and p27kip1 expression in injured rat sciatic nerve. Cheng X, et al. J Mol Neurosci, 2013 Sep. PMID 23370976
    4. Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets. Lu H, et al. Cell Cycle, 2011 Oct 1. PMID 21937878, Free PMC Article
    5. Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells. Kang SW, et al. Exp Cell Res, 2005 Oct 1. PMID 16038898

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JAB1 promotes neuropathic pain via positively regulating JNK and NF-kappaB activation
      Title: JAB1 is Involved in Neuropathic Pain by Regulating JNK and NF-κB Activation After Chronic Constriction Injury.
    2. VCP and Jab1 provide a novel signaling pathway for testicular ischemia and may play an important role in ischemia-reperfusion injury induced cell death in rat testis.
      Title: Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury.
    3. Sciatic nerve crush resulted in a significant upregulation of Jab1.
      Title: Dynamic changes of Jab1 and p27kip1 expression in injured rat sciatic nerve.
    4. Jab1/CSN5, when elevated in certain tumors, may evade triggering E2F1 aopotosis through the frequent, simultaneous co-activation of PI3K activity.
      Title: Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deneddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 1
    Names
    GPS-1
    JAB1-containing signalosome subunit 1
    SGN1
    signalosome subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270939.1 → NP_001257868.1  COP9 signalosome complex subunit 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, com pared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BC061746, CB792560, X87885
      UniProtKB/Swiss-Prot
      P97834
      Related
      ENSRNOP00000103317.1, ENSRNOT00000160627.1
      Conserved Domains (2) summary
      pfam01399
      Location:320 → 424
      PCI; PCI domain
      pfam10602
      Location:123 → 305
      RPN7; 26S proteasome subunit RPN7

    2. NM_053969.3 → NP_446421.3  COP9 signalosome complex subunit 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC061746, CB771566
      UniProtKB/Swiss-Prot
      P97834
      UniProtKB/TrEMBL
      A0A0G2JT06
      Related
      ENSRNOP00000066704.3, ENSRNOT00000071645.4
      Conserved Domains (2) summary
      pfam01399
      Location:359 → 463
      PCI; PCI domain
      pfam10602
      Location:162 → 344
      RPN7; 26S proteasome subunit RPN7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106548646..106553729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268313.1 → XP_063124383.1  COP9 signalosome complex subunit 1 isoform X6

      UniProtKB/TrEMBL
      A6HLJ7
      Related
      ENSRNOP00000111333.1, ENSRNOT00000174039.1

    2. XM_063268312.1 → XP_063124382.1  COP9 signalosome complex subunit 1 isoform X5

      Related
      ENSRNOP00000069778.2, ENSRNOT00000085821.3

    3. XM_063268314.1 → XP_063124384.1  COP9 signalosome complex subunit 1 isoform X7

    4. XM_063268308.1 → XP_063124378.1  COP9 signalosome complex subunit 1 isoform X1

    5. XM_063268309.1 → XP_063124379.1  COP9 signalosome complex subunit 1 isoform X2

    6. XM_063268311.1 → XP_063124381.1  COP9 signalosome complex subunit 1 isoform X4

    7. XM_063268310.1 → XP_063124380.1  COP9 signalosome complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      A6HLJ9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97834.1 GenPept UniProtKB/Swiss-Prot:P97834

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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