U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ptf1a pancreas associated transcription factor 1a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117034, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ptf1aprovided by RGD
    Official Full Name
    pancreas associated transcription factor 1aprovided by RGD
    Primary source
    RGD:621709
    See related
    EnsemblRapid:ENSRNOG00000016902 AllianceGenome:RGD:621709
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in exocrine pancreas development and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in pancreatic agenesis 1. Orthologous to human PTF1A (pancreas associated transcription factor 1a). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 8.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptf1a in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (86959621..86961475)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (82051281..82053135)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (86199623..86201477)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556079 Neighboring gene uncharacterized LOC134482617 Neighboring gene methionine sulfoxide reductase B2 Neighboring gene similar to human chromosome 10 open reading frame 67 Neighboring gene uncharacterized LOC134482618

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within amacrine cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amacrine cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amacrine cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebellum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebellum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exocrine pancreas development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within generation of neurons ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in generation of neurons ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in generation of neurons ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hindbrain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hindbrain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neural retina development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neural retina development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retina layer formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retina layer formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within retina morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinoic acid receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pancreas transcription factor 1 subunit alpha
    Names
    PTF1-p48
    bHLH transcription factor p48
    p48 DNA-binding subunit of transcription factor PTF1
    pancreas specific transcription factor, 1a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053964.2NP_446416.1  pancreas transcription factor 1 subunit alpha

      See identical proteins and their annotated locations for NP_446416.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q64305
      UniProtKB/TrEMBL
      A6JMA2
      Related
      ENSRNOP00000022727.1, ENSRNOT00000022727.4
      Conserved Domains (1) summary
      cd11417
      Location:164218
      bHLH_TS_PTF1A; basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      86959621..86961475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)