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    Baz2a bromodomain adjacent to zinc finger domain, 2A [ Mus musculus (house mouse) ]

    Gene ID: 116848, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Baz2aprovided by MGI
    Official Full Name
    bromodomain adjacent to zinc finger domain, 2Aprovided by MGI
    Primary source
    MGI:MGI:2151152
    See related
    Ensembl:ENSMUSG00000040054 AllianceGenome:MGI:2151152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tip5; Walp3; mKIAA0314; C030005G16Rik
    Summary
    Enables chromatin-protein adaptor activity; lysine-acetylated histone binding activity; and nucleic acid binding activity. Involved in DNA methylation-dependent heterochromatin formation; negative regulation of transcription by RNA polymerase I; and rDNA heterochromatin formation. Acts upstream of or within chromatin remodeling. Located in nucleolus and rDNA heterochromatin. Part of NoRC complex and chromatin silencing complex. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and paraxial mesenchyme. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 35.9), testis adult (RPKM 35.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Baz2a in Genome Data Viewer
    Location:
    10 D3; 10 76.4 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127927453..127965172)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128091370..128129303)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta Neighboring gene STARR-positive B cell enhancer ABC_E8377 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127529132-127529333 Neighboring gene STARR-positive B cell enhancer ABC_E8993 Neighboring gene microRNA 677 Neighboring gene STARR-seq mESC enhancer starr_28259 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127534859-127535012 Neighboring gene STARR-seq mESC enhancer starr_28261 Neighboring gene predicted gene, 51821 Neighboring gene RNA binding motif, single stranded interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11466 Neighboring gene STARR-seq mESC enhancer starr_28269 Neighboring gene predicted gene 4556

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BAZ2A safeguards genome architecture of ground-state pluripotent stem cells. Dalcher D, et al. EMBO J, 2020 Dec 1. PMID 33433018, Free PMC Article
    2. CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5. Ling T, et al. Biochem Biophys Res Commun, 2013 Jul 19. PMID 23796711
    3. The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus. Mayer C, et al. EMBO Rep, 2008 Aug. PMID 18600236, Free PMC Article
    4. TIP5 primes prostate luminal cells for the oncogenic transformation mediated by PTEN-loss. Pietrzak K, et al. Proc Natl Acad Sci U S A, 2020 Feb 18. PMID 32024754, Free PMC Article
    5. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Santoro R, et al. Nat Genet, 2002 Nov. PMID 12368916

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.
      Title: In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.
    2. BAZ2A safeguards genome architecture of ground-state pluripotent stem cells.
      Title: BAZ2A safeguards genome architecture of ground-state pluripotent stem cells.
    3. TIP5 is critical for the initiation of prostate cancer of luminal origin mediated by Pten-loss whereas it is dispensable once Pten-loss mediated transformation is established.
      Title: TIP5 primes prostate luminal cells for the oncogenic transformation mediated by PTEN-loss.
    4. NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.
      Title: CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5.
    5. Tip5 not only mediates the establishment of rDNA silencing but also the formation of perinucleolar heterochromatin that contains centric and pericentric repeats.
      Title: The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats.
    6. Data show that MOF acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that SIRT1 (removes the acetyl group from K633.
      Title: Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.
    7. Mutations that disrupt the stem-loop structure impair binding of TIP5, the large subunit of NoRC, to pRNA and abolish targeting of NoRC to nucleoli.
      Title: The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus.
    8. Overexpression of TIP5, the large subunit of NoRC, mediates deacetylation of nucleosomes near the rDNA promoter. TIP5 associates with HDAC1 in vivo & in vitro. Deletion of the C-terminal PHD finger & bromodomain abolishes the interaction of TIP5 & HDAC1.
      Title: The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.
    9. The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
      Title: The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin-protein adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rDNA heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NoRC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bromodomain adjacent to zinc finger domain protein 2A
    Names
    TTF-I-interacting protein 5
    transcription termination factor I-interacting protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054078.2 → NP_473419.2  bromodomain adjacent to zinc finger domain protein 2A

      See identical proteins and their annotated locations for NP_473419.2

      Status: VALIDATED

      Source sequence(s)
      AC131120, AC166817
      Consensus CDS
      CCDS36088.1
      UniProtKB/TrEMBL
      A0A5F8MPQ7, F8VPM0
      Related
      ENSMUSP00000044359.9, ENSMUST00000045621.9
      Conserved Domains (8) summary
      cd05503
      Location:1780 → 1876
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:839 → 901
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 516
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:407 → 533
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:541 → 613
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1662 → 1708
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1150 → 1420
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1423 → 1457
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127927453..127965172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243278.4 → XP_011241580.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011241580.1

      UniProtKB/TrEMBL
      A0A1W2P6X9, E9Q374
      Conserved Domains (8) summary
      cd05503
      Location:1781 → 1877
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    2. XM_030244833.2 → XP_030100693.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPQ7, F8VPM0
      Conserved Domains (8) summary
      cd05503
      Location:1780 → 1876
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:839 → 901
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 516
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:407 → 533
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:541 → 613
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1662 → 1708
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1150 → 1420
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1423 → 1457
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    3. XM_011243283.4 → XP_011241585.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011241585.1

      UniProtKB/TrEMBL
      A0A1W2P6X9, E9Q374
      Conserved Domains (8) summary
      cd05503
      Location:1781 → 1877
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    4. XM_011243285.4 → XP_011241587.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      See identical proteins and their annotated locations for XP_011241587.1

      UniProtKB/TrEMBL
      A0A5F8MPQ7, F8VPM0
      Conserved Domains (8) summary
      cd05503
      Location:1780 → 1876
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:839 → 901
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 516
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:407 → 533
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:541 → 613
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1662 → 1708
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1150 → 1420
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1423 → 1457
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    5. XM_036155519.1 → XP_036011412.1  bromodomain adjacent to zinc finger domain protein 2A isoform X4

      UniProtKB/TrEMBL
      A0A5F8MPQ7

    6. XM_011243280.4 → XP_011241582.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011241582.1

      UniProtKB/TrEMBL
      A0A1W2P6X9, E9Q374
      Conserved Domains (8) summary
      cd05503
      Location:1781 → 1877
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    7. XM_030244832.2 → XP_030100692.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A1W2P6X9, E9Q374
      Conserved Domains (8) summary
      cd05503
      Location:1781 → 1877
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    8. XM_011243282.4 → XP_011241584.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011241584.1

      UniProtKB/TrEMBL
      A0A1W2P6X9, E9Q374
      Conserved Domains (8) summary
      cd05503
      Location:1781 → 1877
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    9. XM_030244830.1 → XP_030100690.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A1W2P6X9, E9Q374
      Conserved Domains (8) summary
      cd05503
      Location:1781 → 1877
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    10. XM_006513115.4 → XP_006513178.1  bromodomain adjacent to zinc finger domain protein 2A isoform X3

      UniProtKB/TrEMBL
      A0A1W2P6X9
      Conserved Domains (8) summary
      cd05503
      Location:1780 → 1876
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    11. XM_006513114.4 → XP_006513177.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      See identical proteins and their annotated locations for XP_006513177.1

      UniProtKB/TrEMBL
      A0A5F8MPQ7, F8VPM0
      Conserved Domains (8) summary
      cd05503
      Location:1780 → 1876
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:839 → 901
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 516
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:407 → 533
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:541 → 613
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1662 → 1708
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1150 → 1420
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1423 → 1457
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    12. XM_011243284.4 → XP_011241586.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011241586.1

      UniProtKB/TrEMBL
      A0A1W2P6X9, E9Q374
      Related
      ENSMUSP00000151445.2, ENSMUST00000217851.2
      Conserved Domains (8) summary
      cd05503
      Location:1781 → 1877
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    13. XM_011243286.4 → XP_011241588.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      See identical proteins and their annotated locations for XP_011241588.1

      UniProtKB/TrEMBL
      A0A5F8MPQ7, F8VPM0
      Related
      ENSMUSP00000151961.2, ENSMUST00000220049.2
      Conserved Domains (8) summary
      cd05503
      Location:1780 → 1876
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:839 → 901
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 516
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:407 → 533
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:541 → 613
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1662 → 1708
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1150 → 1420
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1423 → 1457
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    14. XM_030244835.2 → XP_030100695.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPQ7, F8VPM0
      Conserved Domains (8) summary
      cd05503
      Location:1780 → 1876
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:839 → 901
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 516
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:407 → 533
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:541 → 613
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1662 → 1708
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1150 → 1420
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1423 → 1457
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    15. XM_030244831.2 → XP_030100691.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A1W2P6X9, E9Q374
      Related
      ENSMUSP00000129803.3, ENSMUST00000170054.9
      Conserved Domains (8) summary
      cd05503
      Location:1781 → 1877
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:840 → 902
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 517
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:408 → 534
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:542 → 614
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1663 → 1709
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1151 → 1421
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1424 → 1458
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    16. XM_030244834.2 → XP_030100694.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPQ7, F8VPM0
      Conserved Domains (8) summary
      cd05503
      Location:1780 → 1876
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:839 → 901
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03307
      Location:269 → 516
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:407 → 533
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01397
      Location:541 → 613
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1662 → 1708
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:1150 → 1420
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:1423 → 1457
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    17. XM_011243287.4 → XP_011241589.1  bromodomain adjacent to zinc finger domain protein 2A isoform X5

      Conserved Domains (6) summary
      cd05503
      Location:1240 → 1336
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:299 → 361
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:10 → 73
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1122 → 1168
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam03154
      Location:610 → 880
      Atrophin-1; Atrophin-1 family
      pfam15613
      Location:883 → 917
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YE5.2 GenPept UniProtKB/Swiss-Prot:Q91YE5

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