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    Il13 interleukin 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116553, updated on 2-Nov-2024

    Summary

    Official Symbol
    Il13provided by RGD
    Official Full Name
    interleukin 13provided by RGD
    Primary source
    RGD:68949
    See related
    EnsemblRapid:ENSRNOG00000007652 AllianceGenome:RGD:68949
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables interleukin-13 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of gene expression; and regulation of monoatomic cation transmembrane transport. Located in extracellular space. Used to study asthma; extrinsic allergic alveolitis; and lipoid nephrosis. Biomarker of several diseases, including alcoholic hepatitis; middle cerebral artery infarction; peptic esophagitis; prostatic hypertrophy; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 4.2) See more
    Orthologs
    NEW
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    Genomic context

    See Il13 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38290926..38293483, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (37790130..37792687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (38982909..38985466, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 3a Neighboring gene interleukin 4 Neighboring gene RAD50 double strand break repair protein Neighboring gene interleukin 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-13 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-13-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-13-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of NAD(P)H oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of immunoglobulin production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monoatomic ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of pancreatic stellate cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of proton transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nicotine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-13
    Names
    IL-13
    T-cell activation protein P600

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053828.1NP_446280.1  interleukin-13 precursor

      See identical proteins and their annotated locations for NP_446280.1

      Status: PROVISIONAL

      Source sequence(s)
      L26913
      UniProtKB/Swiss-Prot
      P42203
      UniProtKB/TrEMBL
      A6HED9
      Related
      ENSRNOP00000010121.1, ENSRNOT00000010121.4
      Conserved Domains (1) summary
      pfam03487
      Location:21130
      IL13; Interleukin-13

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      38290926..38293483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)