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    Sorbs2 sorbin and SH3 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114901, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sorbs2provided by RGD
    Official Full Name
    sorbin and SH3 domain containing 2provided by RGD
    Primary source
    RGD:620061
    See related
    EnsemblRapid:ENSRNOG00000013391 AllianceGenome:RGD:620061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Argbp2
    Summary
    Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in cell growth involved in cardiac muscle cell development. Located in dendrite and neuronal cell body. Orthologous to human SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 391.2), Heart (RPKM 367.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sorbs2 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53167795..53481300, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46435220..46748743, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (49626205..49820223, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U6atac minor spliceosomal RNA Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 100 Neighboring gene uncharacterized LOC120097373 Neighboring gene uncharacterized LOC120097374 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120097435 Neighboring gene uncharacterized LOC134482381 Neighboring gene toll-like receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology. Lee SE, et al. Proc Natl Acad Sci U S A, 2016 Jun 14. PMID 27226294, Free PMC Article
    2. Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy. Nakatani S, et al. Exp Diabetes Res, 2011. PMID 22007191, Free PMC Article
    3. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. Bang C, et al. J Clin Invest, 2014 May. PMID 24743145, Free PMC Article
    4. Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation. Hallock PT, et al. Mol Cell Biol, 2016 Jan 15. PMID 26527617, Free PMC Article
    5. CAP (Cbl associated protein) regulates receptor-mediated endocytosis. Tosoni D, et al. FEBS Lett, 2009 Jan 22. PMID 19116150

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that nArgBP2 functions to regulate spine morphogenesis and subsequent spine-synapse formation at glutamatergic synapses.
      Title: nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology.
    2. Data suggest that SORBS2 is up-regulated in podocytes of glomeruli and may be associated with development and progression of diabetic nephropathy in a model of type 2 diabetes, possibly through reorganization of actin filaments.
      Title: Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy.
    3. ArgBP2 is a scaffold protein that control the balance between adhesion and motility by coordinating the function of multiple signaling pathways converging on the actin cytoskeleton.
      Title: The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell growth involved in cardiac muscle cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of skeletal muscle acetylcholine-gated channel clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorbin and SH3 domain-containing protein 2
    Names
    Arg/Abl-interacting protein ArgBP2
    arg-binding protein 2
    arg/Abl-interacting protein 2
    nArgBP2
    neural ArgBP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053770.3 → NP_446222.3  sorbin and SH3 domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      O35413, Q923T8
      Related
      ENSRNOP00000098300.2, ENSRNOT00000120667.2
      Conserved Domains (4) summary
      smart00459
      Location:167 → 217
      Sorb; Sorbin homologous domain
      cd11917
      Location:1136 → 1196
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:962 → 1016
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1037 → 1093
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      53167795..53481300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094137.2 → XP_038950065.1  sorbin and SH3 domain-containing protein 2 isoform X15

      UniProtKB/Swiss-Prot
      O35413, Q923T8
      UniProtKB/TrEMBL
      A6JPR1
      Related
      ENSRNOP00000094779.3, ENSRNOT00000111730.3
      Conserved Domains (4) summary
      smart00459
      Location:167 → 217
      Sorb; Sorbin homologous domain
      cd11917
      Location:1135 → 1195
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:961 → 1015
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1036 → 1092
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    2. XM_063275002.1 → XP_063131072.1  sorbin and SH3 domain-containing protein 2 isoform X12

      Related
      ENSRNOP00000089017.2, ENSRNOT00000115009.2

    3. XM_063275036.1 → XP_063131106.1  sorbin and SH3 domain-containing protein 2 isoform X46

      Related
      ENSRNOP00000098297.2, ENSRNOT00000120664.2

    4. XM_063275034.1 → XP_063131104.1  sorbin and SH3 domain-containing protein 2 isoform X44

    5. XM_063275031.1 → XP_063131101.1  sorbin and SH3 domain-containing protein 2 isoform X41

    6. XM_063275032.1 → XP_063131102.1  sorbin and SH3 domain-containing protein 2 isoform X42

    7. XM_063275029.1 → XP_063131099.1  sorbin and SH3 domain-containing protein 2 isoform X40

    8. XM_063275028.1 → XP_063131098.1  sorbin and SH3 domain-containing protein 2 isoform X39

    9. XM_063275019.1 → XP_063131089.1  sorbin and SH3 domain-containing protein 2 isoform X31

    10. XM_063275027.1 → XP_063131097.1  sorbin and SH3 domain-containing protein 2 isoform X38

    11. XM_063275025.1 → XP_063131095.1  sorbin and SH3 domain-containing protein 2 isoform X37

    12. XM_063275024.1 → XP_063131094.1  sorbin and SH3 domain-containing protein 2 isoform X36

    13. XM_063275005.1 → XP_063131075.1  sorbin and SH3 domain-containing protein 2 isoform X17

    14. XM_063275018.1 → XP_063131088.1  sorbin and SH3 domain-containing protein 2 isoform X30

    15. XM_063275017.1 → XP_063131087.1  sorbin and SH3 domain-containing protein 2 isoform X29

    16. XM_063275010.1 → XP_063131080.1  sorbin and SH3 domain-containing protein 2 isoform X22

      Related
      ENSRNOP00000091476.2, ENSRNOT00000113085.2

    17. XM_063275009.1 → XP_063131079.1  sorbin and SH3 domain-containing protein 2 isoform X21

    18. XM_063275023.1 → XP_063131093.1  sorbin and SH3 domain-containing protein 2 isoform X35

    19. XM_063275022.1 → XP_063131092.1  sorbin and SH3 domain-containing protein 2 isoform X34

    20. XM_063275004.1 → XP_063131074.1  sorbin and SH3 domain-containing protein 2 isoform X14

    21. XM_063275016.1 → XP_063131086.1  sorbin and SH3 domain-containing protein 2 isoform X28

    22. XM_063275021.1 → XP_063131091.1  sorbin and SH3 domain-containing protein 2 isoform X33

    23. XM_063275003.1 → XP_063131073.1  sorbin and SH3 domain-containing protein 2 isoform X13

      UniProtKB/TrEMBL
      F1LPM3
      Related
      ENSRNOP00000029182.5, ENSRNOT00000029628.8

    24. XM_063275000.1 → XP_063131070.1  sorbin and SH3 domain-containing protein 2 isoform X11

    25. XM_063275015.1 → XP_063131085.1  sorbin and SH3 domain-containing protein 2 isoform X27

    26. XM_063275014.1 → XP_063131084.1  sorbin and SH3 domain-containing protein 2 isoform X26

    27. XM_063274998.1 → XP_063131068.1  sorbin and SH3 domain-containing protein 2 isoform X9

      Related
      ENSRNOP00000098299.1, ENSRNOT00000120666.2

    28. XM_063274997.1 → XP_063131067.1  sorbin and SH3 domain-containing protein 2 isoform X8

    29. XM_063275013.1 → XP_063131083.1  sorbin and SH3 domain-containing protein 2 isoform X25

    30. XM_063275012.1 → XP_063131082.1  sorbin and SH3 domain-containing protein 2 isoform X24

    31. XM_063274996.1 → XP_063131066.1  sorbin and SH3 domain-containing protein 2 isoform X7

    32. XM_063275011.1 → XP_063131081.1  sorbin and SH3 domain-containing protein 2 isoform X23

    33. XM_063275008.1 → XP_063131078.1  sorbin and SH3 domain-containing protein 2 isoform X20

    34. XM_063275007.1 → XP_063131077.1  sorbin and SH3 domain-containing protein 2 isoform X19

      Related
      ENSRNOP00000090759.2, ENSRNOT00000096919.2

    35. XM_063275006.1 → XP_063131076.1  sorbin and SH3 domain-containing protein 2 isoform X18

    36. XM_063274994.1 → XP_063131064.1  sorbin and SH3 domain-containing protein 2 isoform X5

    37. XM_063274991.1 → XP_063131061.1  sorbin and SH3 domain-containing protein 2 isoform X2

    38. XM_063274995.1 → XP_063131065.1  sorbin and SH3 domain-containing protein 2 isoform X6

    39. XM_063274993.1 → XP_063131063.1  sorbin and SH3 domain-containing protein 2 isoform X4

    40. XM_063274992.1 → XP_063131062.1  sorbin and SH3 domain-containing protein 2 isoform X3

    41. XM_063274989.1 → XP_063131059.1  sorbin and SH3 domain-containing protein 2 isoform X1

    42. XM_063275037.1 → XP_063131107.1  sorbin and SH3 domain-containing protein 2 isoform X46

    43. XM_063275035.1 → XP_063131105.1  sorbin and SH3 domain-containing protein 2 isoform X45

    44. XM_063275033.1 → XP_063131103.1  sorbin and SH3 domain-containing protein 2 isoform X43

      Related
      ENSRNOP00000077815.1, ENSRNOT00000118135.3

    45. XM_063275020.1 → XP_063131090.1  sorbin and SH3 domain-containing protein 2 isoform X32

      UniProtKB/TrEMBL
      A0A8I6ABV1

    46. XM_063275030.1 → XP_063131100.1  sorbin and SH3 domain-containing protein 2 isoform X40

    47. XM_063275026.1 → XP_063131096.1  sorbin and SH3 domain-containing protein 2 isoform X37

    48. XM_039094138.2 → XP_038950066.1  sorbin and SH3 domain-containing protein 2 isoform X16

      UniProtKB/Swiss-Prot
      O35413, Q923T8
      Conserved Domains (4) summary
      cd11917
      Location:1120 → 1180
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:946 → 1000
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1021 → 1077
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170 → 211
      Sorb; Sorbin homologous domain

    49. XM_063274999.1 → XP_063131069.1  sorbin and SH3 domain-containing protein 2 isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35413.2 GenPept UniProtKB/Swiss-Prot:O35413

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