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    Laptm4b lysosomal-associated protein transmembrane 4B [ Mus musculus (house mouse) ]

    Gene ID: 114128, updated on 18-Sep-2024

    Summary

    Official Symbol
    Laptm4bprovided by MGI
    Official Full Name
    lysosomal-associated protein transmembrane 4Bprovided by MGI
    Primary source
    MGI:MGI:1890494
    See related
    Ensembl:ENSMUSG00000022257 AllianceGenome:MGI:1890494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAPTM4beta; C330023P13Rik
    Summary
    Predicted to enable ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Predicted to be located in several cellular components, including endosome; lysosome; and plasma membrane. Predicted to be active in lysosomal membrane. Is expressed in several structures, including central nervous system; incisor; liver; retina; and submandibular gland primordium. Orthologous to human LAPTM4B (lysosomal protein transmembrane 4 beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 150.7), ovary adult (RPKM 83.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Laptm4b in Genome Data Viewer
    Location:
    15 B3.1; 15 13.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34238279..34284448)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34238026..34284295)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41291 Neighboring gene metadherin Neighboring gene predicted gene, 38594 Neighboring gene STARR-seq mESC enhancer starr_38323 Neighboring gene STARR-seq mESC enhancer starr_38324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34167683-34167792 Neighboring gene STARR-seq mESC enhancer starr_38325 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34225853-34226040 Neighboring gene matrilin 2 Neighboring gene RIKEN cDNA 9430069I07 gene Neighboring gene STARR-seq mESC enhancer starr_38326 Neighboring gene predicted gene, 24523 Neighboring gene ribosomal protein L30

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in multivesicular body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in multivesicular body, internal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in multivesicular body, internal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    lysosomal-associated transmembrane protein 4B
    Names
    lysosomal-associated transmembrane protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033521.4NP_277056.1  lysosomal-associated transmembrane protein 4B

      See identical proteins and their annotated locations for NP_277056.1

      Status: VALIDATED

      Source sequence(s)
      AC133101
      Consensus CDS
      CCDS27416.1
      UniProtKB/Swiss-Prot
      Q91XQ6
      UniProtKB/TrEMBL
      B2CZK6
      Related
      ENSMUSP00000022867.4, ENSMUST00000022867.5
      Conserved Domains (1) summary
      cl04276
      Location:9227
      Mtp; Golgi 4-transmembrane spanning transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34238279..34284448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)