P2rx5 purinergic receptor P2X 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2rx5provided by RGD
Official Full Name: purinergic receptor P2X 5provided by RGD
Primary source: RGD:620256
See related: EnsemblRapid:ENSRNOG00000019208 AllianceGenome:RGD:620256
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2x5
Summary: Enables ATP binding activity; identical protein binding activity; and monoatomic ion channel activity. Involved in several processes, including positive regulation of calcium ion import across plasma membrane; regulation of skeletal muscle tissue regeneration; and response to ATP. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human P2RX5 (purinergic receptor P2X 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 101.3), Muscle (RPKM 42.8) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (58276329..58291108)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (57777737..57789426)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (59725438..59737126)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of the role of the left flipper domain in the weak ATP response of rat P2X5 receptors
Title: Altered allostery of the left flipper domain underlies the weak ATP response of rat P2X5 receptors.
The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp.
Title: Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp.
The P2X5 receptor subunit is located in neuronal somata.
Title: Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.
activation of a P2X receptor inhibits proliferation, stimulates expression of markers of muscle cell differentiation and increases the rate of myotube formation
Title: ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells.
analysis of topology, helix-helix interactions, and oligomerization of P2X5 subunits
Title: P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate.
the Ca(2+)-sensitized homomeric rP2X(5) receptor is similar in agonist profile to homomeric rP2X(1)-although it can be distinguished from the latter by GTP agonism, antagonist profile, and the modulatory effects of H(+) and Zn(2+) ions.
Title: Sensitization by extracellular Ca(2+) of rat P2X(5) receptor and its pharmacological properties compared with rat P2X(1).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP-gated ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ligand-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic anion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	TAS Traceable Author Statement more info	PubMed
involved_in osteoclast maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed
involved_in response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle tissue growth	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: P2X purinoceptor 5

Names: ATP receptor; purinergic receptor P2X, ligand-gated ion channel, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080780.3 → NP_542958.3 P2X purinoceptor 5

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

A6HGI1, G3V8I0, P51578, Q64613

Related

ENSRNOP00000026156.2, ENSRNOT00000026156.7

Conserved Domains (1) summary

TIGR00863
Location:1 → 373

P2X; cation transporter protein