KIF2C kinesin family member 2C [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF2Cprovided by HGNC
Official Full Name: kinesin family member 2Cprovided by HGNC
Primary source: HGNC:HGNC:6393
See related: Ensembl:ENSG00000142945 MIM:604538; AllianceGenome:HGNC:6393
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MCAK; CT139; KNSL6
Summary: This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression: Biased expression in testis (RPKM 39.1), bone marrow (RPKM 9.5) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (44739837..44767767)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (44610697..44638762)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (45205509..45233439)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
Title: Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
Title: Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.
Title: KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.
Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.
Title: Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.
Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD.
Title: Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD.
KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA-Seq and scRNA-Seq data.
Title: KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA-Seq and scRNA-Seq data.
Large-Scale Transcriptome Data Analysis Identifies KIF2C as a Potential Therapeutic Target Associated With Immune Infiltration in Prostate Cancer.
Title: Large-Scale Transcriptome Data Analysis Identifies KIF2C as a Potential Therapeutic Target Associated With Immune Infiltration in Prostate Cancer.
Activation of the TGF-beta1/Smad signaling by KIF2C contributes to the malignant phenotype of thyroid carcinoma cells.
Title: Activation of the TGF-β1/Smad signaling by KIF2C contributes to the malignant phenotype of thyroid carcinoma cells.
Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays.
Title: Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays.
KIF2C: a novel link between Wnt/beta-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
Title: KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells	PubMed
Vpr	vpr	HIV-1 Vpr upregulates KIF2C in HeLa cells within 12 hours of exposure	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

KIF2C_9208 (e-PCR)
- UniSTS:468493

D1S1340 (e-PCR)
- UniSTS:149537

SHGC-74693 (e-PCR)
- UniSTS:50016

RH123469 (e-PCR)
- UniSTS:135856

STS-U63743 (e-PCR)
- UniSTS:2015

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables centromeric DNA binding	TAS Traceable Author Statement more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule depolymerization	TAS Traceable Author Statement more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule plus-end	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF2C

Names: kinesin-like protein 6; mitotic centromere-associated kinesin; testis tissue sperm-binding protein Li 68n

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001297655.2 → NP_001284584.1 kinesin-like protein KIF2C isoform 2

See identical proteins and their annotated locations for NP_001284584.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AB264115, AK300756, BU615368

UniProtKB/TrEMBL

A8K3S3, B7Z6Q6

Conserved Domains (2) summary

cd01367
Location:217 → 545

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:223 → 546

Kinesin; Kinesin motor domain
NM_001297656.2 → NP_001284585.1 kinesin-like protein KIF2C isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as tsMCAK) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK302267, AY026505, BC014924, BU615368, DC404550

Consensus CDS

CCDS72774.1

UniProtKB/TrEMBL

A8K3S3

Related

ENSP00000361291.1, ENST00000372217.5

Conserved Domains (2) summary

cd01367
Location:204 → 532

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:210 → 533

Kinesin; Kinesin motor domain
NM_001297657.2 → NP_001284586.1 kinesin-like protein KIF2C isoform 4

See identical proteins and their annotated locations for NP_001284586.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK302267, BC014924, BU615368, DC399082

UniProtKB/TrEMBL

A8K3S3, B7Z7M6, E9PDS6

Conserved Domains (2) summary

cd01367
Location:145 → 473

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:151 → 474

Kinesin; Kinesin motor domain
NM_006845.4 → NP_006836.2 kinesin-like protein KIF2C isoform 1

See identical proteins and their annotated locations for NP_006836.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AU130795, BC008764, BC014924, BU615368

Consensus CDS

CCDS512.1

UniProtKB/Swiss-Prot

B3ITR9, Q5JR88, Q6ICU1, Q96C18, Q96HB8, Q99661, Q9BWV8

UniProtKB/TrEMBL

A0A140VKF1, A8K3S3

Related

ENSP00000361298.4, ENST00000372224.9

Conserved Domains (1) summary

cd01367
Location:258 → 586

KISc_KIF2_like; Kinesin motor domain, KIF2-like group