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    RNA18SP3 RNA, 18S ribosomal pseudogene 3 [ Homo sapiens (human) ]

    Gene ID: 109864277, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RNA18SP3provided by HGNC
    Official Full Name
    RNA, 18S ribosomal pseudogene 3provided by HGNC
    Primary source
    HGNC:HGNC:53534
    See related
    AllianceGenome:HGNC:53534
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. This locus represents a likely pseudogene and copy of the 18S ribosomal RNA, part of an incomplete rDNA repeat unit whose chromosomal location is unknown. [provided by RefSeq, May 2017]
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    Genomic context

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    See RNA18SP3 in Genome Data Viewer
    Location:
    chromosome: 21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Unplaced Scaffold NT_167214.1 (153050..154918)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (5824928..5826796)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (5519383..5521251)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Unplaced Scaffold NT_167214.1 (153050..154918)

    NT_167214.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507412 Neighboring gene RNA, 45S pre-ribosomal N5 Neighboring gene RNA, 28S ribosomal N5 Neighboring gene cell division cycle 27 homolog pseudogene Neighboring gene origin of replication in ribosomal DNA intergenic spacer Neighboring gene uncharacterized LOC124905315 Neighboring gene RNA, 5.8S ribosomal pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The complete sequence of a human genome. Nurk S, et al. Science, 2022 Apr. PMID 35357919, Free PMC Article
    2. A Portrait of Ribosomal DNA Contacts with Hi-C Reveals 5S and 45S rDNA Anchoring Points in the Folded Human Genome. Yu S, et al. Genome Biol Evol, 2016 Dec 31. PMID 27797956, Free PMC Article
    3. The human 18S ribosomal RNA gene: evolution and stability. Gonzalez IL, et al. Am J Hum Genet, 1986 Apr. PMID 2422931, Free PMC Article
    4. A novel strategy for constructing clustered point mutations. Haltiner M, et al. Nucleic Acids Res, 1985 Feb 11. PMID 2987803, Free PMC Article
    5. Evolutionary changes of sequences and factors that direct transcription termination of human and mouse ribsomal genes. Bartsch I, et al. Mol Cell Biol, 1987 Jul. PMID 3649563, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054871.1 

      Range
      101..1969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NT_167214.1 Reference GRCh38.p14 Primary Assembly

      Range
      153050..154918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      5824928..5826796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      5519383..5521251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_146139.1: Suppressed sequence

      Description
      NR_146139.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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