Grm5 glutamate receptor, metabotropic 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grm5provided by MGI
Official Full Name: glutamate receptor, metabotropic 5provided by MGI
Primary source: MGI:MGI:1351342
See related: Ensembl:ENSMUSG00000049583 AllianceGenome:MGI:1351342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glu5R; Gprc1e; mGluR5; mGluR5b; 6430542K11Rik
Summary: Enables protein tyrosine kinase activator activity. Involved in several processes, including cellular response to amyloid-beta; learning or memory; and positive regulation of calcium-mediated signaling. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in cytoplasm; neuron projection; and plasma membrane. Is active in Schaffer collateral - CA1 synapse and dendrite. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 10.5), frontal lobe adult (RPKM 8.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 49.01 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (87233212..87784271)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (87583981..88135063)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor alpha.
Title: Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α.
Metabotropic glutamate receptor 5 promotes blood-brain barrier recovery after traumatic brain injury.
Title: Metabotropic glutamate receptor 5 promotes blood-brain barrier recovery after traumatic brain injury.
Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity.
Title: Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity.
Striatal mGlu5-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways.
Title: Striatal mGlu(5)-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways.
mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis.
Title: mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis.
Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
Title: Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior.
Title: mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior.
Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to the Postsynaptic Density and Cell Type Specifically Mediates Excessive Grooming.
Title: Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to the Postsynaptic Density and Cell Type Specifically Mediates Excessive Grooming.
Purinergic ionotropic P2X7 and metabotropic glutamate mGlu5 receptors crosstalk influences pro-inflammatory conditions in microglia.
Title: Purinergic ionotropic P2X7 and metabotropic glutamate mGlu(5) receptors crosstalk influences pro-inflammatory conditions in microglia.
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.
Title: Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.

Submit: New GeneRIF Correction See all GeneRIFs (190)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144288 (e-PCR)
- UniSTS:233533

SGC30871 (e-PCR)
- UniSTS:33861

AI850523 (e-PCR)
- UniSTS:165537

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables A2A adenosine receptor binding	IEA Inferred from Electronic Annotation more info
enables A2A adenosine receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables PLC activating G protein-coupled glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in desensitization of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in desensitization of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in astrocyte projection	IEA Inferred from Electronic Annotation more info
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metabotropic glutamate receptor 5

Names: G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081414.2 → NP_001074883.1 metabotropic glutamate receptor 5 isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (a) lacks an alternate in-frame exon in the 3' coding region, compared to variant b. The resulting isoform (a) lacks a segment near the C-terminus, compared to isoform b.

Source sequence(s)

AC113033, BC096533, BC144727, BY721282, CJ124875

Consensus CDS

CCDS40013.1

UniProtKB/TrEMBL

B7ZMP7, E9QMC2, F6WSV0

Related

ENSMUSP00000118393.3, ENSMUST00000125009.9

Conserved Domains (5) summary

PHA03247
Location:950 → 1154

PHA03247; large tegument protein UL36; Provisional

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1122 → 1171

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
NM_001143834.1 → NP_001137306.1 metabotropic glutamate receptor 5 isoform b precursor

See identical proteins and their annotated locations for NP_001137306.1

Status: VALIDATED

Description

Transcript Variant: This variant (b) represents the longer transcript and encodes the longer isoform (b).

Source sequence(s)

AC113033, AC116820, BC096533, BY721282, CJ124875

Consensus CDS

CCDS52305.1

UniProtKB/Swiss-Prot

Q3UVX5

UniProtKB/TrEMBL

B2BH30, B7ZMP7, F6YJ89

Conserved Domains (5) summary

PHA03247
Location:982 → 1186

PHA03247; large tegument protein UL36; Provisional

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

87233212..87784271

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152559.1 → XP_036008452.1 metabotropic glutamate receptor 5 isoform X1

UniProtKB/Swiss-Prot

Q3UVX5

UniProtKB/TrEMBL

B2BH30, B7ZMP7, F6YJ89

Conserved Domains (5) summary

PHA03247
Location:982 → 1186

PHA03247; large tegument protein UL36; Provisional

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_011241643.4 → XP_011239945.1 metabotropic glutamate receptor 5 isoform X1

See identical proteins and their annotated locations for XP_011239945.1

UniProtKB/Swiss-Prot

Q3UVX5

UniProtKB/TrEMBL

B2BH30, B7ZMP7, F6YJ89

Conserved Domains (5) summary

PHA03247
Location:982 → 1186

PHA03247; large tegument protein UL36; Provisional

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_036152560.1 → XP_036008453.1 metabotropic glutamate receptor 5 isoform X1

UniProtKB/Swiss-Prot

Q3UVX5

UniProtKB/TrEMBL

B2BH30, B7ZMP7, F6YJ89

Related

ENSMUSP00000114927.3, ENSMUST00000155358.3

Conserved Domains (5) summary

PHA03247
Location:982 → 1186

PHA03247; large tegument protein UL36; Provisional

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_036152561.1 → XP_036008454.1 metabotropic glutamate receptor 5 isoform X2

UniProtKB/TrEMBL

B7ZMP7, E9QMC2, F6WSV0

Conserved Domains (5) summary

PHA03247
Location:950 → 1154

PHA03247; large tegument protein UL36; Provisional

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1122 → 1171

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_036152562.1 → XP_036008455.1 metabotropic glutamate receptor 5 isoform X2

UniProtKB/TrEMBL

B7ZMP7, E9QMC2, F6WSV0

Related

ENSMUSP00000102884.3, ENSMUST00000107263.9

Conserved Domains (5) summary

PHA03247
Location:950 → 1154

PHA03247; large tegument protein UL36; Provisional

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1122 → 1171

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_006507184.5 → XP_006507247.1 metabotropic glutamate receptor 5 isoform X3

UniProtKB/TrEMBL

Q4VA56

Conserved Domains (3) summary

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001033224.1: Suppressed sequence

Description

NM_001033224.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.