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    CEBPG CCAAT enhancer binding protein gamma [ Homo sapiens (human) ]

    Gene ID: 1054, updated on 19-Sep-2024

    Summary

    Official Symbol
    CEBPGprovided by HGNC
    Official Full Name
    CCAAT enhancer binding protein gammaprovided by HGNC
    Primary source
    HGNC:HGNC:1837
    See related
    Ensembl:ENSG00000153879 MIM:138972; AllianceGenome:HGNC:1837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPE1BP; IG/EBP-1
    Summary
    The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 20.4), colon (RPKM 19.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CEBPG in Genome Data Viewer
    Location:
    19q13.11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (33373709..33382686)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (35893494..35902471)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33864615..33873592)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:33841025-33842224 Neighboring gene RPS3A pseudogene 50 Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:33868709-33869402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:33880343-33881245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:33883417-33884181 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:33886169-33886998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:33886999-33887828 Neighboring gene uncharacterized LOC124904692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:33897606-33898163 Neighboring gene peptidase D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:33909297-33910182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:33976998-33977858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:33977859-33978718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:33978719-33979578 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:33994022-33994738 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:34001184-34001982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:34011998-34012961 Neighboring gene uncharacterized LOC105372370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:34012962-34013924

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection increases basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Knockdown of C/EBPalpha, C/EBPgamma, and AP-1 by siRNA shows significant reduction of CCL5 levels, suggesting that C/EBPalpha, C/EBPgamma, and AP-1 proteins are involved in Nef-mediated upregulation of CCL5 PubMed
    Tat tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in enucleate erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in integrated stress response signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in liver development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA repair IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    CCAAT/enhancer-binding protein gamma
    Names
    CCAAT/enhancer binding protein (C/EBP), gamma
    c/EBP gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252296.2NP_001239225.1  CCAAT/enhancer-binding protein gamma

      See identical proteins and their annotated locations for NP_001239225.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC008744, BC013128, CN353219
      Consensus CDS
      CCDS12432.1
      UniProtKB/Swiss-Prot
      B2R946, P53567, Q5U052
      Related
      ENSP00000466022.2, ENST00000585933.2
      Conserved Domains (1) summary
      cd14713
      Location:60120
      bZIP_CEBPG; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein gamma (CEBPG): a DNA-binding and dimerization domain
    2. NM_001806.4NP_001797.1  CCAAT/enhancer-binding protein gamma

      See identical proteins and their annotated locations for NP_001797.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC008744, BC007582, BC013128
      Consensus CDS
      CCDS12432.1
      UniProtKB/Swiss-Prot
      B2R946, P53567, Q5U052
      Related
      ENSP00000284000.2, ENST00000284000.9
      Conserved Domains (1) summary
      cd14713
      Location:60120
      bZIP_CEBPG; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein gamma (CEBPG): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      33373709..33382686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      35893494..35902471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)