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    NANOG Nanog homeobox [ Canis lupus familiaris (dog) ]

    Gene ID: 100856473, updated on 8-Mar-2024

    Summary

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    Gene symbol
    NANOG
    Gene description
    Nanog homeobox
    See related
    Ensembl:ENSCAFG00845029777
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NANOG in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (37614640..37620732)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (9348312..9354207, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (8831817..8837819, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (37494510..37500598)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (37530317..37536638)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 3 Neighboring gene U6 spliceosomal RNA Neighboring gene NANOG neighbor homeobox Neighboring gene solute carrier family 2 member 3 Neighboring gene uncharacterized LOC119866428 Neighboring gene uncharacterized LOC111092727

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair. Erwin WM, et al. Spine (Phila Pa 1976), 2013 Feb 1. PMID 22772571
    2. Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts. Koh S, et al. Stem Cells Dev, 2013 Mar 15. PMID 23016947, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We created canine induced pluripotent stem cells (ciPSCs) from adult fibroblasts using OKSM transduction. These cells, grown in FGF2 and LIF, exhibited pluripotency markers including NANOG, and differentiated into all germ layers, both in vitro and in vivo. This study highlights the unique aspects of canine epigenetic reprogramming and its similarity to embryonic stem cells in other mammalian species.
      Title: Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts.
    2. Data indicate that intervertebral disc (IVD)-derived stem/progenitor cells express Oct3/4, Sox2, CD133 (PROM1), Nanog, and Nestin.
      Title: Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein NANOG

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      37614640..37620732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038437912.1 → XP_038293840.1  homeobox protein NANOG

      UniProtKB/TrEMBL
      A0A8C0QUR0
      Related
      ENSCAFP00845041406.1, ENSCAFT00845052746.1
      Conserved Domains (1) summary
      pfam00046
      Location:100 → 153
      Homeobox; Homeobox domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      37494510..37500598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038514321.1 → XP_038370249.1  homeobox protein NANOG

      Conserved Domains (1) summary
      pfam00046
      Location:100 → 153
      Homeobox; Homeobox domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      37530317..37536638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038640367.1 → XP_038496295.1  homeobox protein NANOG

      Conserved Domains (1) summary
      pfam00046
      Location:100 → 153
      Homeobox; Homeobox domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      8831817..8837819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038576121.1 → XP_038432049.1  homeobox protein NANOG

      UniProtKB/TrEMBL
      A0A8C0QUR0
      Conserved Domains (1) summary
      pfam00046
      Location:100 → 153
      Homeobox; Homeobox domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9348312..9354207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038459499.1 → XP_038315427.1  homeobox protein NANOG

      UniProtKB/TrEMBL
      A0A8C0QUR0
      Conserved Domains (1) summary
      pfam00046
      Location:100 → 153
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials