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    NTRK3 neurotrophic receptor tyrosine kinase 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 100856261, updated on 11-Apr-2024

    Summary

    Official Symbol
    NTRK3provided by VGNC
    Official Full Name
    neurotrophic receptor tyrosine kinase 3provided by VGNC
    Primary source
    VGNC:VGNC:49932
    See related
    Ensembl:ENSCAFG00845003493
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NTRK3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (51548386..51933727, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (53770192..54150627, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (51620674..52005592, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (51071744..51456495, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (51281270..51665830, complement)

    Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095217 Neighboring gene BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene tudor domain-containing protein 3-like Neighboring gene mitochondrial ribosomal protein L46

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables neurotrophin binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables neurotrophin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    NT-3 growth factor receptor
    Names
    neurotrophic tyrosine kinase, receptor, type 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051807.1 Reference ROS_Cfam_1.0

      Range
      51548386..51933727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038661287.1XP_038517215.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8C0M7V2, A0A8C0PK75, A0A8I3MT47
      Related
      ENSCAFP00845005030.1, ENSCAFT00845006332.1
      Conserved Domains (7) summary
      cd05094
      Location:531831
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    2. XM_038661289.1XP_038517217.1  NT-3 growth factor receptor isoform X3

      UniProtKB/TrEMBL
      A0A8I3MRD4, A0A8P0P1I3
      Related
      ENSCAFP00845004978.1, ENSCAFT00845006270.1
      Conserved Domains (7) summary
      cd05094
      Location:464764
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:3861
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:147232
      ig; Immunoglobulin domain
      pfam13855
      Location:3693
      LRR_8; Leucine rich repeat
      pfam16920
      Location:96141
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:151154
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:237329
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    3. XM_038661285.1XP_038517213.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8C0M7V2, A0A8C0PK75, A0A8I3MT47
      Conserved Domains (7) summary
      cd05094
      Location:531831
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    4. XM_038661288.1XP_038517216.1  NT-3 growth factor receptor isoform X2

      UniProtKB/TrEMBL
      A0A8C0M6T3, A0A8C0PWX8
      Related
      ENSCAFP00845005035.1, ENSCAFT00845006337.1
      Conserved Domains (7) summary
      cd05094
      Location:531817
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    5. XM_038661291.1XP_038517219.1  NT-3 growth factor receptor isoform X5

      UniProtKB/TrEMBL
      A0A8C0PPG0
      Conserved Domains (7) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    6. XM_038661290.1XP_038517218.1  NT-3 growth factor receptor isoform X4

      UniProtKB/TrEMBL
      A0A8C0MDN5, A0A8C0PPG0, A0A8I3MQ26
      Related
      ENSCAFP00845005053.1, ENSCAFT00845006359.1
      Conserved Domains (7) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049263.1 Alternate UMICH_Zoey_3.1

      Range
      51071744..51456495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038471858.1XP_038327786.1  NT-3 growth factor receptor isoform X1

    2. XM_038471860.1XP_038327788.1  NT-3 growth factor receptor isoform X3

    3. XM_038471857.1XP_038327785.1  NT-3 growth factor receptor isoform X1

    4. XM_038471859.1XP_038327787.1  NT-3 growth factor receptor isoform X2

    5. XM_038471862.1XP_038327790.1  NT-3 growth factor receptor isoform X5

    6. XM_038471861.1XP_038327789.1  NT-3 growth factor receptor isoform X4

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

      Range
      51281270..51665830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038597105.1XP_038453033.1  NT-3 growth factor receptor isoform X1

    2. XM_038597107.1XP_038453035.1  NT-3 growth factor receptor isoform X3

    3. XM_038597104.1XP_038453032.1  NT-3 growth factor receptor isoform X1

    4. XM_038597106.1XP_038453034.1  NT-3 growth factor receptor isoform X2

    5. XM_038597109.1XP_038453037.1  NT-3 growth factor receptor isoform X5

    6. XM_038597108.1XP_038453036.1  NT-3 growth factor receptor isoform X4

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

      Range
      51620674..52005592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038532784.1XP_038388712.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8C0M7V2, A0A8C0PK75, A0A8I3MT47
      Conserved Domains (7) summary
      cd05094
      Location:531831
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    2. XM_038532786.1XP_038388714.1  NT-3 growth factor receptor isoform X3

      UniProtKB/TrEMBL
      A0A8I3MRD4, A0A8P0P1I3
      Conserved Domains (7) summary
      cd05094
      Location:464764
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:3861
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:147232
      ig; Immunoglobulin domain
      pfam13855
      Location:3693
      LRR_8; Leucine rich repeat
      pfam16920
      Location:96141
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:151154
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:237329
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    3. XM_038532783.1XP_038388711.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8C0M7V2, A0A8C0PK75, A0A8I3MT47
      Conserved Domains (7) summary
      cd05094
      Location:531831
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    4. XM_038532785.1XP_038388713.1  NT-3 growth factor receptor isoform X2

      UniProtKB/TrEMBL
      A0A8C0M6T3, A0A8C0PWX8
      Conserved Domains (7) summary
      cd05094
      Location:531817
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    5. XM_038532788.1XP_038388716.1  NT-3 growth factor receptor isoform X5

      UniProtKB/TrEMBL
      A0A8C0PPG0
      Conserved Domains (7) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    6. XM_038532787.1XP_038388715.1  NT-3 growth factor receptor isoform X4

      UniProtKB/TrEMBL
      A0A8C0MDN5, A0A8C0PPG0, A0A8I3MQ26
      Conserved Domains (7) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      53770192..54150627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038474552.1XP_038330480.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8C0M7V2, A0A8C0PK75, A0A8I3MT47
      Conserved Domains (7) summary
      cd05094
      Location:531831
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    2. XM_038474567.1XP_038330495.1  NT-3 growth factor receptor isoform X3

      UniProtKB/TrEMBL
      A0A8I3MRD4, A0A8P0P1I3
      Conserved Domains (7) summary
      cd05094
      Location:464764
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:3861
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:147232
      ig; Immunoglobulin domain
      pfam13855
      Location:3693
      LRR_8; Leucine rich repeat
      pfam16920
      Location:96141
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:151154
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:237329
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    3. XM_038474544.1XP_038330472.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8C0M7V2, A0A8C0PK75, A0A8I3MT47
      Conserved Domains (7) summary
      cd05094
      Location:531831
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    4. XM_038474562.1XP_038330490.1  NT-3 growth factor receptor isoform X2

      UniProtKB/TrEMBL
      A0A8C0M6T3, A0A8C0PWX8
      Conserved Domains (7) summary
      cd05094
      Location:531817
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    5. XM_038474585.1XP_038330513.1  NT-3 growth factor receptor isoform X5

      UniProtKB/TrEMBL
      A0A8C0PPG0
      Conserved Domains (7) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    6. XM_038474577.1XP_038330505.1  NT-3 growth factor receptor isoform X4

      UniProtKB/TrEMBL
      A0A8C0MDN5, A0A8C0PPG0, A0A8I3MQ26
      Conserved Domains (7) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains