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    HCRTR1 hypocretin receptor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 100855896, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HCRTR1provided by VGNC
    Official Full Name
    hypocretin receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:41623
    See related
    Ensembl:ENSCAFG00845005853
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See HCRTR1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (70050261..70058799, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (66064201..66072739, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (68881857..68890396, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (66886002..66894539, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (67882448..67890972, complement)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene collagen type XVI alpha 1 chain Neighboring gene uncharacterized LOC119870368 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene uncharacterized LOC106557744 Neighboring gene tubulointerstitial nephritis antigen like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. Mishima K, et al. Sleep, 2008 Aug. PMID 18714784, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We measured hcrtR1 and hcrtR2 expression in the frontal cortex and pons using the RT-PCR method in murine models, in canine models and in humans.
      Title: Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables orexin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    orexin receptor type 1
    Names
    hypocretin (orexin) receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      70050261..70058799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038659614.1 → XP_038515542.1  orexin receptor type 1

      UniProtKB/TrEMBL
      A0A8I3MV93, A0A8I3RSX8, A0A8P0P8J8, A0A8P0SG02
      Related
      ENSCAFP00845008086.1, ENSCAFT00845010405.1
      Conserved Domains (1) summary
      cd15208
      Location:49 → 371
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_038659613.1 → XP_038515541.1  orexin receptor type 1

      UniProtKB/TrEMBL
      A0A8I3MV93, A0A8I3RSX8, A0A8P0P8J8, A0A8P0SG02
      Related
      ENSCAFP00845008078.1, ENSCAFT00845010395.1
      Conserved Domains (1) summary
      cd15208
      Location:49 → 371
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      66886002..66894539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038470466.1 → XP_038326394.1  orexin receptor type 1

    2. XM_038470465.1 → XP_038326393.1  orexin receptor type 1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      67882448..67890972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038595530.1 → XP_038451458.1  orexin receptor type 1

    2. XM_038595529.1 → XP_038451457.1  orexin receptor type 1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      68881857..68890396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038531308.1 → XP_038387236.1  orexin receptor type 1

      UniProtKB/TrEMBL
      A0A8C0PK36, A0A8C0R7D3, A0A8I3MV93, A0A8P0SG02

    2. XM_038531307.1 → XP_038387235.1  orexin receptor type 1

      UniProtKB/TrEMBL
      A0A8C0PK36, A0A8C0R7D3, A0A8I3MV93, A0A8P0SG02

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      66064201..66072739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022412329.2 → XP_022268037.1  orexin receptor type 1

      UniProtKB/TrEMBL
      A0A8I3MV93, A0A8I3RSX8, A0A8P0P8J8, A0A8P0SG02
      Conserved Domains (1) summary
      cd15208
      Location:49 → 371
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_003638937.5 → XP_003638985.1  orexin receptor type 1

      UniProtKB/TrEMBL
      A0A8I3MV93, A0A8I3RSX8, A0A8P0P8J8, A0A8P0SG02
      Conserved Domains (1) summary
      cd15208
      Location:49 → 371
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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