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    CDK2 cyclin dependent kinase 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 100855704, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CDK2provided by VGNC
    Official Full Name
    cyclin dependent kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:39051
    See related
    Ensembl:ENSCAFG00845005902
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CDK2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (307657..313366)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (362779..368479)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (652514..658220)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (285465..291170)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (528243..533942)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene diacylglycerol kinase alpha Neighboring gene premelanosome protein Neighboring gene RAB5B, member RAS oncogene family Neighboring gene sulfite oxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      307657..313366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038678950.1 → XP_038534878.1  cyclin-dependent kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NEG2, A0A8I3N128
      Related
      ENSCAFP00845008144.1, ENSCAFT00845010477.1
      Conserved Domains (1) summary
      cd07860
      Location:3 → 334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    2. XM_038678952.1 → XP_038534880.1  cyclin-dependent kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0NMM0, A0A8I3MY98
      Related
      ENSCAFP00845008149.1, ENSCAFT00845010482.1
      Conserved Domains (1) summary
      cd07860
      Location:3 → 286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    3. XM_038678953.1 → XP_038534881.1  cyclin-dependent kinase 2 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 244
      PKc_like; Protein Kinases, catalytic domain

    4. XM_038678951.1 → XP_038534879.1  cyclin-dependent kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:4 → 299
      PKc_like; Protein Kinases, catalytic domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      285465..291170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038487727.1 → XP_038343655.1  cyclin-dependent kinase 2 isoform X1

      Conserved Domains (1) summary
      cd07860
      Location:3 → 334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    2. XM_038487729.1 → XP_038343657.1  cyclin-dependent kinase 2 isoform X3

      Conserved Domains (1) summary
      cd07860
      Location:3 → 286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    3. XM_038487730.1 → XP_038343658.1  cyclin-dependent kinase 2 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 244
      PKc_like; Protein Kinases, catalytic domain

    4. XM_038487728.1 → XP_038343656.1  cyclin-dependent kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:4 → 299
      PKc_like; Protein Kinases, catalytic domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      528243..533942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038613586.1 → XP_038469514.1  cyclin-dependent kinase 2 isoform X1

      Conserved Domains (1) summary
      cd07860
      Location:3 → 334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    2. XM_038613588.1 → XP_038469516.1  cyclin-dependent kinase 2 isoform X3

      Conserved Domains (1) summary
      cd07860
      Location:3 → 286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    3. XM_038613589.1 → XP_038469517.1  cyclin-dependent kinase 2 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 244
      PKc_like; Protein Kinases, catalytic domain

    4. XM_038613587.1 → XP_038469515.1  cyclin-dependent kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:4 → 299
      PKc_like; Protein Kinases, catalytic domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      652514..658220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038549615.1 → XP_038405543.1  cyclin-dependent kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NEG2, A0A8I3N128
      Conserved Domains (1) summary
      cd07860
      Location:3 → 334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    2. XM_038549617.1 → XP_038405545.1  cyclin-dependent kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0NMM0, A0A8I3MY98
      Conserved Domains (1) summary
      cd07860
      Location:3 → 286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    3. XM_038549618.1 → XP_038405546.1  cyclin-dependent kinase 2 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 244
      PKc_like; Protein Kinases, catalytic domain

    4. XM_038549616.1 → XP_038405544.1  cyclin-dependent kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:4 → 299
      PKc_like; Protein Kinases, catalytic domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      362779..368479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005625479.4 → XP_005625536.1  cyclin-dependent kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_005625536.1

      UniProtKB/TrEMBL
      A0A8C0NEG2, A0A8I3N128
      Conserved Domains (1) summary
      cd07860
      Location:3 → 334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    2. XM_003639320.5 → XP_003639368.1  cyclin-dependent kinase 2 isoform X3

      See identical proteins and their annotated locations for XP_003639368.1

      UniProtKB/TrEMBL
      A0A8C0NMM0, A0A8I3MY98
      Conserved Domains (1) summary
      cd07860
      Location:3 → 286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    3. XM_022424033.2 → XP_022279741.1  cyclin-dependent kinase 2 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 244
      PKc_like; Protein Kinases, catalytic domain

    4. XM_022424031.2 → XP_022279739.1  cyclin-dependent kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:4 → 299
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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