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    DGKA diacylglycerol kinase alpha [ Canis lupus familiaris (dog) ]

    Gene ID: 100855691, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DGKAprovided by VGNC
    Official Full Name
    diacylglycerol kinase alphaprovided by VGNC
    Primary source
    VGNC:VGNC:39915
    See related
    Ensembl:ENSCAFG00845005690
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See DGKA in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (276898..299341)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (332016..354466)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (621826..644195)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (254787..277147)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (497503..519931)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase D-like Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2 Neighboring gene RAB5B, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Chianale F, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160093, Free PMC Article
    2. Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling. Chianale F, et al. Mol Biol Cell, 2007 Dec. PMID 17898083, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings highlight DGKalpha as the central element of a lipid signaling pathway linking tyrosine kinase growth-factor receptors to regulation of aPKCs and RhoGDI
      Title: Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI.
    2. Dgkalpha, activated downstream of tyrosine kinase receptors and Src, regulates crucial steps directing Rac activation and Rac-dependent remodeling of actin cytoskeleton and focal contacts in migrating epithelial cells
      Title: Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase alpha
    Names
    diacylglycerol kinase, alpha 80kDa

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      276898..299341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038678944.1 → XP_038534872.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Related
      ENSCAFP00845007873.1, ENSCAFT00845010093.1
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    2. XM_038678942.1 → XP_038534870.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    3. XM_038678943.1 → XP_038534871.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    4. XM_038678945.1 → XP_038534873.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Related
      ENSCAFP00845007891.1, ENSCAFT00845010124.1
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    5. XM_038678946.1 → XP_038534874.1  diacylglycerol kinase alpha isoform X5

      UniProtKB/TrEMBL
      A0A8I3MXK7
      Conserved Domains (6) summary
      smart00046
      Location:446 → 567
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 251
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:338 → 399
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:269 → 329
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl02440
      Location:588 → 674
      DAGK_acc; Diacylglycerol kinase accessory domain

    6. XM_038678940.1 → XP_038534868.1  diacylglycerol kinase alpha isoform X2

      UniProtKB/TrEMBL
      A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:563 → 744
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 226
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:313 → 374
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:244 → 304
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    7. XM_038678939.1 → XP_038534867.1  diacylglycerol kinase alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0NX06, A0A8I3MQ22, A0A8I3MXK7
      Related
      ENSCAFP00845007908.1, ENSCAFT00845010147.1
      Conserved Domains (6) summary
      smart00045
      Location:588 → 769
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:446 → 567
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 251
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:338 → 399
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:269 → 329
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    8. XM_038678941.1 → XP_038534869.1  diacylglycerol kinase alpha isoform X3

      UniProtKB/TrEMBL
      A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:558 → 739
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:416 → 537
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:44 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:308 → 369
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:239 → 299
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      254787..277147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038487720.1 → XP_038343648.1  diacylglycerol kinase alpha isoform X4

      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    2. XM_038487718.1 → XP_038343646.1  diacylglycerol kinase alpha isoform X4

      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    3. XM_038487719.1 → XP_038343647.1  diacylglycerol kinase alpha isoform X4

      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    4. XM_038487721.1 → XP_038343649.1  diacylglycerol kinase alpha isoform X4

      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    5. XM_038487723.1 → XP_038343651.1  diacylglycerol kinase alpha isoform X5

      Conserved Domains (6) summary
      smart00046
      Location:446 → 567
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 251
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:338 → 399
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:269 → 329
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl02440
      Location:588 → 674
      DAGK_acc; Diacylglycerol kinase accessory domain

    6. XM_038487716.1 → XP_038343644.1  diacylglycerol kinase alpha isoform X2

      Conserved Domains (6) summary
      smart00045
      Location:563 → 744
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 226
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:313 → 374
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:244 → 304
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    7. XM_038487715.1 → XP_038343643.1  diacylglycerol kinase alpha isoform X1

      Conserved Domains (6) summary
      smart00045
      Location:588 → 769
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:446 → 567
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 251
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:338 → 399
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:269 → 329
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    8. XM_038487717.1 → XP_038343645.1  diacylglycerol kinase alpha isoform X3

      Conserved Domains (6) summary
      smart00045
      Location:558 → 739
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:416 → 537
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:44 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:308 → 369
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:239 → 299
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      497503..519931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038613579.1 → XP_038469507.1  diacylglycerol kinase alpha isoform X4

    2. XM_038613577.1 → XP_038469505.1  diacylglycerol kinase alpha isoform X4

    3. XM_038613578.1 → XP_038469506.1  diacylglycerol kinase alpha isoform X4

    4. XM_038613580.1 → XP_038469508.1  diacylglycerol kinase alpha isoform X4

    5. XM_038613581.1 → XP_038469509.1  diacylglycerol kinase alpha isoform X5

    6. XM_038613575.1 → XP_038469503.1  diacylglycerol kinase alpha isoform X2

    7. XM_038613574.1 → XP_038469502.1  diacylglycerol kinase alpha isoform X1

    8. XM_038613576.1 → XP_038469504.1  diacylglycerol kinase alpha isoform X3

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      621826..644195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038549608.1 → XP_038405536.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    2. XM_038549606.1 → XP_038405534.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    3. XM_038549607.1 → XP_038405535.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    4. XM_038549609.1 → XP_038405537.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    5. XM_038549610.1 → XP_038405538.1  diacylglycerol kinase alpha isoform X5

      UniProtKB/TrEMBL
      A0A8I3MXK7
      Conserved Domains (6) summary
      smart00046
      Location:446 → 567
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 251
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:338 → 399
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:269 → 329
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl02440
      Location:588 → 674
      DAGK_acc; Diacylglycerol kinase accessory domain

    6. XM_038549604.1 → XP_038405532.1  diacylglycerol kinase alpha isoform X2

      UniProtKB/TrEMBL
      A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:563 → 744
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 226
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:313 → 374
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:244 → 304
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    7. XM_038549603.1 → XP_038405531.1  diacylglycerol kinase alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0NX06, A0A8I3MQ22, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:588 → 769
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:446 → 567
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 251
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:338 → 399
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:269 → 329
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    8. XM_038549605.1 → XP_038405533.1  diacylglycerol kinase alpha isoform X3

      UniProtKB/TrEMBL
      A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:558 → 739
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:416 → 537
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:44 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:308 → 369
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:239 → 299
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      332016..354466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005625477.4 → XP_005625534.1  diacylglycerol kinase alpha isoform X4

      See identical proteins and their annotated locations for XP_005625534.1

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    2. XM_022424030.2 → XP_022279738.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    3. XM_038632442.1 → XP_038488370.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    4. XM_038632460.1 → XP_038488388.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q5Y6, A0A8C0R888, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:269 → 330
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:200 → 260
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    5. XM_038632420.1 → XP_038488348.1  diacylglycerol kinase alpha isoform X2

      UniProtKB/TrEMBL
      A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:563 → 744
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 226
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:313 → 374
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:244 → 304
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    6. XM_038632411.1 → XP_038488339.1  diacylglycerol kinase alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0NX06, A0A8I3MQ22, A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:588 → 769
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:446 → 567
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:182 → 251
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:74 → 178
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:338 → 399
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:269 → 329
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    7. XM_005625475.4 → XP_005625532.3  diacylglycerol kinase alpha isoform X3

      UniProtKB/TrEMBL
      A0A8I3MXK7
      Conserved Domains (6) summary
      smart00045
      Location:558 → 739
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:416 → 537
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:44 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20890
      Location:308 → 369
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl00040
      Location:239 → 299
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    Nucleotide Protein
    Heading Accession and Version

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