MIR4463 microRNA 4463 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR4463provided by HGNC
Official Full Name: microRNA 4463provided by HGNC
Primary source: HGNC:HGNC:41665
See related: Ensembl:ENSG00000263533 miRBase:MI0016811; AllianceGenome:HGNC:41665
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 6q14.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (75428407..75428473)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (76138123..76138189)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells.
Title: miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells.
MicroRNA-4463 facilitates the development of colon cancer by suppression of the expression of PPP1R12B.
Title: MicroRNA-4463 facilitates the development of colon cancer by suppression of the expression of PPP1R12B.
MiR-4463 expression in the aortic smooth muscle cells in the arteriosclerosis obliterans patients.MiR-4463 is a novel modulator of the vascular smooth muscle cell migration by targetting AMOT expression.
Title: MiR-4463 inhibits the migration of human aortic smooth muscle cells by AMOT.
Downregulation of miR-4463 enhances PNUTS expression, which promotes PTEN nuclear translocation, with increased AKT phosphorylation and increased cell survival, thus providing a rationale for the anti-apoptotic role of the downregulation of miR-4463.
Title: Downregulation of MicroRNA-4463 Attenuates High-Glucose- and Hypoxia-Induced Endothelial Cell Injury by Targeting PNUTS.
the upregulation of miR4463 may enhance hydrogen peroxideinduced oxidative stress and promote apoptosis in human umbilical vein endothelial cells in vitro.
Title: Roles of miR‑4463 in H2O2‑induced oxidative stress in human umbilical vein endothelial cells.
The level of miR-4463 was significantly increased in Arteriosclerosis Obliterans.
Title: Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.