MIR4728 microRNA 4728 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR4728provided by HGNC
Official Full Name: microRNA 4728provided by HGNC
Primary source: HGNC:HGNC:41632
See related: Ensembl:ENSG00000265178 miRBase:MI0017365; AllianceGenome:HGNC:41632
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 17q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (39726495..39726561)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (40590055..40590121)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (37882748..37882814)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[miR-485-3p and miR-4728-5p as Tumor Suppressors in Pathogenesis of Colorectal Cancer].
Title: [miR-485-3p and miR-4728-5p as Tumor Suppressors in Pathogenesis of Colorectal Cancer].
HER2-intronic miR-4728-5p facilitates HER2 expression and accelerates cell proliferation and migration by targeting EBP1 in breast cancer.
Title: HER2-intronic miR-4728-5p facilitates HER2 expression and accelerates cell proliferation and migration by targeting EBP1 in breast cancer.
Long noncoding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR47285p/OGG1 axis.
Title: Long non‑coding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR‑4728‑5p/OGG1 axis.
Studied association of coamplification of microRNA 4728 and HER2 inhibitor resistance in HER2 amplified breast cancers.
Title: Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy.
Low miR-4728 expression is associated with Ulcerative Colitis-associated Colorectal Neoplasia.
Title: miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling.
this study shows that HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5
Title: HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5.
this study shows that a miR-4728 downregulates PADI2, a novel rheumatoid arthritis risk gene
Title: Significant impact of miRNA-target gene networks on genetics of human complex traits.
MiR-4728-3p and miR-4728-5p were significantly up-regulated in HER2-positive patients compared with HER2-negative breast cancer patients.
Title: MiR-4728-3p could act as a marker of HER2 status.
mir-4728, an intron of the ErbB2 gene, is a negative regulator of MAPK signaling through directly targeting the ERK upstream kinase MST4 and exerts numerous tumor-suppressive properties
Title: ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling.
MiR-4728-3p has alternative functionalities.
Title: The HER2-encoded miR-4728-3p regulates ESR1 through a non-canonical internal seed interaction.

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Phenotypes

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Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.