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    megf8 multiple EGF-like-domains 8 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100496850, updated on 4-Nov-2024

    Summary

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    Official Symbol
    megf8provided by Xenbase
    Official Full Name
    multiple EGF-like-domains 8provided by Xenbase
    Primary source
    Xenbase:XB-GENE-1004120
    See related
    Ensembl:ENSXETG00000034254 AllianceGenome:Xenbase:XB-GENE-1004120
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See megf8 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (107647836..107679504)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (99311440..99343267)

    Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene toll-like receptor 21 Neighboring gene transmembrane protein 145 Neighboring gene cornifelin homolog Neighboring gene cornifelin, gene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multiple epidermal growth factor-like domains protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      107647836..107679504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002936396.5 → XP_002936442.2  multiple epidermal growth factor-like domains protein 8

      See identical proteins and their annotated locations for XP_002936442.2

      UniProtKB/TrEMBL
      A0A6I8PVR0, A0A6I8SE56
      Conserved Domains (9) summary
      PLN02153
      Location:312 → 457
      PLN02153; epithiospecifier protein
      cd00041
      Location:39 → 139
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00054
      Location:2074 → 2108
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1192 → 1241
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:227 → 270
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:936 → 987
      PSI; Plexin repeat
      pfam12947
      Location:1071 → 1098
      EGF_3; EGF domain
      pfam13415
      Location:1531 → 1576
      Kelch_3; Galactose oxidase, central domain
      pfam13418
      Location:1462 → 1505
      Kelch_4; Galactose oxidase, central domain

    2. XM_031906377.1 → XP_031762237.1  multiple epidermal growth factor-like domains protein 8

      UniProtKB/TrEMBL
      A0A6I8PVR0, A0A6I8SE56
      Related
      ENSXETP00000063505.2, ENSXETT00000061125.3
      Conserved Domains (9) summary
      PLN02153
      Location:312 → 457
      PLN02153; epithiospecifier protein
      cd00041
      Location:39 → 139
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00054
      Location:2074 → 2108
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1192 → 1241
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:227 → 270
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:936 → 987
      PSI; Plexin repeat
      pfam12947
      Location:1071 → 1098
      EGF_3; EGF domain
      pfam13415
      Location:1531 → 1576
      Kelch_3; Galactose oxidase, central domain
      pfam13418
      Location:1462 → 1505
      Kelch_4; Galactose oxidase, central domain

    RNA

    1. XR_001171338.3 RNA Sequence

    2. XR_004223656.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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