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    adamts10 ADAM metallopeptidase with thrombospondin type 1 motif 10 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100494667, updated on 4-Nov-2024

    Summary

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    Official Symbol
    adamts10provided by Xenbase
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 10provided by Xenbase
    Primary source
    Xenbase:XB-GENE-961723
    See related
    Ensembl:ENSXETG00000009497 AllianceGenome:Xenbase:XB-GENE-961723
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See adamts10 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (102105348..102159054, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (83126837..83180831, complement)

    Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene zinc finger protein 414 Neighboring gene myosin IF Neighboring gene zeta chain of T cell receptor associated protein kinase 70 Neighboring gene mucin-16-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      102105348..102159054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004910996.4 → XP_004911053.2  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

      UniProtKB/TrEMBL
      A0A6I8QD15, A0A8J1JSI2
      Related
      ENSXETP00000070622.2, ENSXETT00000068638.2
      Conserved Domains (7) summary
      smart00209
      Location:585 → 637
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:276 → 489
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:741 → 855
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:74 → 217
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1105 → 1137
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:504 → 572
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:985 → 1039
      TSP1_ADAMTS; Thrombospondin type 1 domain

    2. XM_031905008.1 → XP_031760868.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

      UniProtKB/TrEMBL
      A0A6I8QD15, A0A8J1JSI2
      Conserved Domains (7) summary
      smart00209
      Location:585 → 637
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:276 → 489
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:741 → 855
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:74 → 217
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1105 → 1137
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:504 → 572
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:985 → 1039
      TSP1_ADAMTS; Thrombospondin type 1 domain

    3. XM_018096944.2 → XP_017952433.2  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X2

      UniProtKB/TrEMBL
      A0A6I8QD15, A0A6I8QWM6
      Related
      ENSXETP00000074038.2, ENSXETT00000071299.2
      Conserved Domains (7) summary
      smart00209
      Location:551 → 603
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:242 → 455
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:707 → 821
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:40 → 183
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1071 → 1103
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:470 → 538
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:951 → 1005
      TSP1_ADAMTS; Thrombospondin type 1 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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